Dietary Nutrient Deficiencies and Risk of Depression (Review Article 2018–2023)

Nutrients, Journal Year: 2023, Volume and Issue: 15(11), P. 2433 - 2433

Published: May 23, 2023

Depression is classified as one of the most common mental disorders. Its prevalence has recently increased, becoming a growing public health threat. This review focuses on clarifying role and importance individual nutrients in diet impact nutrient deficiencies risk depression. Deficiencies such protein, B vitamins, vitamin D, magnesium, zinc, selenium, iron, calcium, omega-3 fatty acids have significant brain nervous system function, which can affect appearance depressive symptoms. However, it important to remember that itself not only factor influencing or helping treat There are many other aspects, physical activity, sleep, stress management, social support, also play an maintaining health. The data observed available analyses based cross-sectional studies. Further studies, including prospective cohort, case-control recommended draw more reliable conclusions.

Language: Английский

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Interaction between diabetes and body mass index on severe headache or migraine in adults: a cross-sectional study

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 19, 2024

Abstract Background Research on the effects of body mass index (BMI) severe headache or migraine is limited and controversial. The aim this study was to explore association between BMI prevalence migraine, with particular interest in diabetes status difference. Methods present used analyzed data from people who participated National Health Nutrition Examination Survey (NHANES) 1999 2004. Logistic regression models restricted cubic spline (RCS) were applied investigate relationship migraine. Results A total 10,074 adults aged 20 years older included study. Body positively related corresponding odds ratio (OR; 95% CI) 1.02 (1.01, 1.03; p < 0.001). And compared participants lowest group (< 25 kg/m 2 ), adjusted ORs for medium (25-29.9 highest (≥ 30 ) 1.14 (95% CI: 0.98–1.32, = 0.09) 1.30 1.11–1.52, 0.0022), respectively. exhibited a linear overall RCS. Our findings also suggested an interaction diabetes. non-linear. OR developing 1.10–1.54) individuals ≥ 29.71 Conclusion higher significantly associated increased can modify them.

Language: Английский

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Low-carbohydrate diet as a nutritional intervention in a major depression disorder: focus on relapse prevention

Nutritional Neuroscience, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: Jan. 21, 2024

Objectives: Mood disorders are trending to be among the leading causes of years lived with disability. Despite multiple treatment options, around 30% patients major depressive disorder (MDD) develop resistant depression (TRD) and fail respond current pharmacological therapies. This study aimed explore potential benefits nutritional strategies, along their molecular mechanisms action, focusing especially on low-carbohydrate diet (LCHD), ketogenic (KD) other strategies based carbohydrates intake reduction.

Language: Английский

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The Novel Imipramine–Magnesium Complex Exerts Antidepressant-Like Activity in Mice Subjected to the Forced Swim Test and the Tail Suspension Test

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 519 - 519

Published: Jan. 23, 2025

The objective of this study was to assess the antidepressant efficacy a novel imipramine–magnesium (IMI–Mg) complex in comparison administration imipramine and magnesium individually. utilized adult male albino Swiss mice. Behavioral assessments were conducted using forced swim test (FST) tail suspension (TST). A locomotor activity exclude false positive results FST TST. Moreover, assessed oxidative stress levels mice subjected acute environmental by measuring glutathione peroxidase, reductase, total oxidant status, antioxidant status. IMI–Mg at doses 5, 10, 20 mg/kg resulted reduction immobility time both behavioral tests, thereby indicating antidepressant-like potential tested complex, which similar one observed after these two compounds as separate drug forms. represents significant advancement provides foundation for future research. This innovative agent has enhance safety profile therapy, streamline treatment protocol, improve patient satisfaction, promote adherence therapeutic regimen.

Language: Английский

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Impact of dietary magnesium intake on depression risk in American adults: a cross-sectional study of the National Health and Nutrition Examination Survey 2005–2020

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 6, 2025

Depression is a major global mental health challenge. Previous research suggests link between magnesium consumption and depression, but the dose-response relationship remains unclear. This study investigates dietary intake depression risk among American adults. Data from 2005-2020 National Health Nutrition Examination Survey (NHANES) were examined. was measured with Patient Questionnaire-9 (PHQ-9), calculated two 24-h meal recalls. We used restricted cubic spline models, logistic regression, sensitivity analyses to assess connection. Among 35,252 participants (mean age: 49.5 ± 17.6 years; 49.9% women), we observed nonlinearity in depression. Below inflection point (366.7 mg/day), odds ratio (OR) 0.998 (95% CI: 0.997-0.999, p < 0.001). Above this point, OR 1.001 1.000-1.002, = 0.007). In aged ≥60 years, association inverse L-shaped, ≥270.7 mg/day increasing incidence by 0.1% per 1 mg/d increase. A nonlinear exists US Age significantly moderates association, suggesting recommendations should be tailored different age groups.

Language: Английский

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Serum magnesium level in a sample of Egyptian patients with major depressive disorder: cross-sectional study

Middle East Current Psychiatry, Journal Year: 2025, Volume and Issue: 32(1)

Published: Feb. 13, 2025

Abstract Background Major depressive disorder (MDD) is a prevalent mental health condition that manifests as profound emotional disturbances and considerable functional deficits. Magnesium (Mg), vital mineral, plays recognized role in numerous neuropsychiatric conditions, including disorders. Nonetheless, the association between circulating Mg concentrations MDD within Egyptian demographic has yet to be definitively elucidated. This study aimed evaluate serum levels patients, assess their correlation with depression severity, explore diagnostic utility of Mg. Results The included 30 newly diagnosed patients healthy controls. Serum were significantly lower (1.880 ± 0.190 mg/dL) compared controls (1.996 0.169 mg/dL, p = 0.015). An inverse relationship notable strength was identified magnesium severity symptoms, quantified using Hamilton Depression Rating Scale (Ham-D17) ( r − 0.592, 0.001). ROC curve analysis determined threshold ≤ 1.8 yielding sensitivity specificity rates 46.7% 80.0%, respectively, an overall accuracy 67%. Conclusions A reduction individuals relative controls, these correlated inversely severity. may serve potential biomarker for its

Language: Английский

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Dietary zinc intake in relation to migraine among adults: a cross sectional study of NHANES 1999–2004

Nutritional Neuroscience, Journal Year: 2023, Volume and Issue: 27(6), P. 667 - 676

Published: Aug. 4, 2023

ABSTRACTBackground Previous studies have revealed that an antioxidant diet is a protective factor against migraine. However, the association between zinc, important obtained from diet, and migraine has received little attention. The purpose of this study was to explore zinc intake with migraine.Methods present used cross-sectional data individuals who participated in National Health Nutrition Examination Survey (NHANES) 1999 2004. Logistic regression models restricted cubic spline were performed migraine.Results A total 9849 adults aged 20 years or older included study. Zinc negatively associated Compared participants lowest group dietary Q1 (≤5.93 mg/day), adjusted ORs for Q2 (5.94–8.38 Q3 (8.39–11.26 Q4 (11.27–15.75 Q5 (≥15.76 mg/day) 0.73 (95% CI: 0.60–0.89, p = 0.004), 0.72 0.55–0.95, 0.02), 0.76 0.58–0.99, 0.04) 0.50–1.05, 0.08), respectively. Our findings also suggested interaction age (P 0.007). Additionally, relationship 20–50 non-linear.Conclusions higher significantly decreased prevalence migraine, can modify them.KEYWORDS: Dietary intakemigraineageNHANEScross-sectional studyinteraction effectrestricted splinesevere headache AcknowledgmentsThe authors are grateful Center Statistics providing publicly available data.Disclosure statementNo potential conflict interest reported by author(s).Availability materialsThe analysis at NHANES website.Ethics approvalAll protocols approved Research Ethics Review Committee Statistics.Additional informationFundingThis work supported Natural Science Foundation China (Grant numbers: 82160227), Jiangxi Province 20224BAB206036), Provincial Department Education Technology Program Project GJJ210125).Notes on contributorsHeqing ZhengHeqing Zheng MD student Neurology, Second Affiliated Hospital Nanchang University.Sheng TianSheng Tian University.Lanxiang WuLanxiang Wu University.Xianhui ZhongXianhui Zhong master candidate Neurology University.Mingxu LiuMingxu Liu University.Xinping YuXinping Yu University.Yonggang XieYonggang Xie University.Wei WuWei Wu, PhD professor University, Nanchang, Jiangxi, China.

Language: Английский

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Dietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose–Response Meta-analysis of Epidemiologic Studies

Nutrition Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: May 29, 2024

Abstract Context The relation of magnesium (Mg) intake with depression was previously investigated by meta-analyses. However, due to limited data, a dose–response analysis not performed. Objective Considering the recently published articles, systematic review and meta-analysis conducted summarize dietary Mg in adults. Data Sources Medline (PubMed), ISI Web Science, Scopus, Google Scholar were comprehensively searched up August 2023. Extraction Observational studies that reported adults included their data extracted. Analysis A total 63 214 participants from 10 cross-sectional 3 cohort current study. Pooling 15 effect sizes 12 (including 50 275 participants) revealed individuals highest had 34% lower risk depression, compared those lowest (RR: 0.66; 95% CI: 0.57, 0.78). Moreover, linear each 100-mg/d increment associated 7% reduced 0.93; 0.90, 0.96). Additionally, based on nonlinear analysis, increasing 170 370 mg/d depression. Analyses also 9 (49 558 representative populations, similar results found 0.71; 0.61, 0.83) 0.96) analysis. Conclusion study shows an inverse dose–dependent association between intakes both general population manner. Systematic Review Registration PROSPERO registration no. CRD42024506570.

Language: Английский

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Association between dietary anthocyanidins intake and depression among US adults: a cross-sectional study (NHANES, 2007–2010 and 2017–2018)

BMC Psychiatry, Journal Year: 2023, Volume and Issue: 23(1)

Published: July 20, 2023

Abstract Background Anthocyanidins encompass a diverse array of compounds that possess notable anti-inflammatory and antioxidant properties with pharmacological activity. However, the correlation between consumption anthocyanidins through diet its impact on depression has yet to be investigated. Methods This study utilized Food Nutrient Database for Dietary Studies (FNDDS) expanded flavonoid intake database, as well data from National Health Nutrition Examination Survey (NHANES) years 2007 2010 2017 2018. The analysis collected was conducted in R, following guidelines outlined official NHANES user guide “Stratified Multi-stage Probability Sampling”. Three different models were developed using logistic regression assess protective effects T3 (representing highest anthocyanidins) against depression. Additionally, aimed investigate whether there existed non-linear relationship dietary prevalence by employing restricted cubic spline (RCS) analysis. Results A total 6,845 eligible participants included this cross-sectional study, their appropriately weighted represent population 89.8 million people United States America. results demonstrated individuals diagnosed had significantly lower compared those without ( P < 0.0001). Moreover, significant differences observed among participant groups regarding socioeconomic status presence chronic physical illnesses (such hypertension, glucose status, kidney disease risk, etc.) 0.05). After adjustment covariates, anthocyanins (T3) reduced risk [OR = 0.67, 95%CI: (0.48–0.95), trend 0.02]. Furthermore, RCS revealed linear anthocyanidin 0.5876). Conclusion Our findings reveal negative association

Language: Английский

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Magnesium supplementation beneficially affects depression in adults with depressive disorder: a systematic review and meta-analysis of randomized clinical trials

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 22, 2023

Background The findings from randomized clinical trials (RCTs) examining the effect of magnesium supplementation on depression are inconsistent. We decided to conduct a meta-analysis that summarizes all evidence impact scores in adults with depressive disorder. Methods conducted systematic search online databases using related keywords up July 2023. included magnesium, contrast placebo, scores. Results Finally, seven were this review, building total sample size 325 individuals ages ranging 20 60 years average. These RCTs resulted eight sizes. Our showed significant decline due intervention supplements [standardized mean difference (SMD): −0.919, 95% CI: −1.443 −0.396, p = 0.001]. Conclusion review suggests can have beneficial depression. Future high-quality larger sizes must be run interpret settings. Systematic registration https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=447909 .

Language: Английский

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