Zeitschrift für Komplementärmedizin,
Journal Year:
2023,
Volume and Issue:
15(06), P. 61 - 65
Published: Dec. 1, 2023
Summary
Tumorassoziierte
Fatigue
ist
ein
Phänomen,
das
viele
Krebspatient*innen
erleben.
Sie
zeichnet
sich
unter
anderem
durch
Symptome
wie
Schwäche,
übermäßiges
Schlafbedürfnis,
Erschöpfung,
Reizbarkeit
sowie
Konzentrations-
und
Gedächtnisstörungen
aus.
Um
die
Beschwerden
bei
zu
lindern,
eignen
verschiedene
Therapieansätze.
Dazu
zählen
Sport
Bewegung,
Entspannungsübungen
zur
Stressreduktion,
Akupunktur
Akupressur
Mittel
aus
der
Phythotherapie
Mistel-
oder
Ginseng-Extrakt.
Frontiers in Oncology,
Journal Year:
2023,
Volume and Issue:
13
Published: Aug. 11, 2023
Breast
cancer
is
the
most
frequent
in
women.
Reduced
physical
activity
and
overweight
are
associated
with
poor
prognosis.
patients
have
a
high
risk
to
gain
weight,
lose
muscle
mass
reduce
during
therapy.
Concepts
urgently
needed
motivate
engage
activity.110
non-metastatic
breast
were
included
prospective
observational
BEGYN-1
study.
Physiological
parameters
body
composition
measured
before
start
of
therapy
then
quarterly
for
one
year.
Patients
used
fitness
tracker
documented
their
diary
throughout
study.Although
not
offered
any
guided
exercise,
despite
restrictions
COVID-19
pandemic,
they
increased
(metabolic
equivalent
task
(MET)
-minutes):
p<0.001),
(decreasing
resting
heart
rate:
p=0.001)
did
weight
(median
-
0.4kg)
over
course
study.Improved
awareness
an
increase
activity,
fitness,
stable
first
year
patients.
Counselling
at
diagnosis
should
wear
document
activities.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2020,
Volume and Issue:
unknown
Published: Jan. 28, 2020
Abstract
Background
Metabolic
disorders
are
prevalent
in
women
with
breast
cancer,
increasing
mortality
and
cancer
recurrence
rates.
Despite
clinical
implications,
the
cause
of
cancer-associated
metabolic
dysfunction
remains
poorly
understood.
Skeletal
muscle
is
crucial
for
insulin-stimulated
glucose
uptake,
thus
key
to
whole-body
homeostasis.
In
this
study,
we
determined
effect
cell-conditioned
media
on
skeletal
uptake
response
insulin.
Method
L6
myotubes
overexpressing
myc-tagged
GLUT4
(GLUT4myc-L6)
were
incubated
40%
conditioned
from
tumorigenic
MCF7
or
BT474,
non-tumorigenic
control
MCF10A
cells.
Mass-spectrometry-based
proteomics
was
applied
detect
molecular
rewiring
muscle.
Expression
myogenesis
inflammation
markers,
translocation,
[
3
H]-2-deoxyglucose
(2DG)
intramyocellular
insulin
signalling
determined.
Results
Breast
induced
proteomic
changes
pathways
related
sarcomere
organisation,
actin
filament
binding,
vesicle
trafficking,
disrupted
myogenic
differentiation,
activated
an
inflammatory
via
NF-κB,
atrophy.
Basal
translocation
2DG
reduced
treated
compared
control.
Insulin
Rho
GTPase
Rac1
blocked
cancer-treated
myotubes,
while
Akt-TBC1D4
unaffected.
Conclusion
Conditioned
BT474
cells
inhibition
by
selectively
blocking
activation
inducing
inflammation.
These
findings
indicate
that
proteome,
inflammation,
could
play
a
role
patients
cancer.
Zeitschrift für Komplementärmedizin,
Journal Year:
2023,
Volume and Issue:
15(06), P. 61 - 65
Published: Dec. 1, 2023
Summary
Tumorassoziierte
Fatigue
ist
ein
Phänomen,
das
viele
Krebspatient*innen
erleben.
Sie
zeichnet
sich
unter
anderem
durch
Symptome
wie
Schwäche,
übermäßiges
Schlafbedürfnis,
Erschöpfung,
Reizbarkeit
sowie
Konzentrations-
und
Gedächtnisstörungen
aus.
Um
die
Beschwerden
bei
zu
lindern,
eignen
verschiedene
Therapieansätze.
Dazu
zählen
Sport
Bewegung,
Entspannungsübungen
zur
Stressreduktion,
Akupunktur
Akupressur
Mittel
aus
der
Phythotherapie
Mistel-
oder
Ginseng-Extrakt.