Evaluating the scientific evidence to support mental health and well-being claims made on probiotic products

Nutrition and Health, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Background Increasing interest in probiotics for mental health has led to products marketed consumers claiming psychological benefits. This study aimed identify claims on probiotic supplements and provide a narrative review of the scientific evidence support these claims. Methods Probiotic with product label were identified. A search literature was performed using Google Scholar, PubMed Cochrane Central Register Controlled Trials. Studies included if primary outcome or biomarker health, they investigated exact strain combination strains as present product, trial conducted either humans animals. Included studies assessed risk bias. Results Fourteen identified containing five different combinations. Eighteen relevant investigating outcomes met inclusion criteria. Ten same provided made. Statistically significant results not universally all products. Conclusion The amount quality benefits made is variable. need grading system facilitate informed consumer decision-making when choosing supplement health.

Language: Английский

---

Probiotics and Synbiotics: Applications, Benefits, and Mechanisms for the Improvement of Human and Ecological Health

Journal of Multidisciplinary Healthcare, Journal Year: 2025, Volume and Issue: Volume 18, P. 1493 - 1510

Published: March 1, 2025

Abstract: This review explores the multifaceted roles and applications of probiotics, emphasizing their significance in maintaining enhancing host health through microbial interactions. It includes concept holobionts symbiotic relationships between hosts microbiomes, illustrating how various microbiota can enhance immunity, support growth, prevent diseases. delves into customization probiotics using molecular genomic techniques, focusing Enterococcus, Bifidobacterium , Lactobacillus species. Furthermore, it discusses effects symbiotics which aids survivability beneficial probiotics. The role microbes gut is emphasized, noting its impact on preventing diseases a stable community. potential therapeutic value ability to treat gastrointestinal diseases, as well strengthen immune system reduce number free radicals that are present body. Additionally, secondary metabolites produced by bacteria gut, such bacteriocins exopolysaccharides, effect human, particularly tract. concludes addressing use traditional medicine novel applications, including treatment endangered wildlife species human ailments. Keywords: health, microbiota, metabolites, synergistic

Language: Английский

---

Progress in Probiotic Science: Prospects of Functional Probiotic‐Based Foods and Beverages

International Journal of Food Science, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

This comprehensive review explores the evolving role of probiotic‐based foods and beverages, highlighting their potential as functional “ future ” that could significantly enhance nutrition, health, overall well‐being. These products are gaining prominence for benefits in gut immune support, holistic wellness. However, success depends on addressing critical safety concerns navigating administrative complexities. Ensuring these do more good than harm involves rigorous evaluations probiotic strains, particularly those sourced from human gastrointestinal tract. Lactic acid bacteria (LABs) serve versatile effective starter cultures development beverages. The emphasizes LABs precision probiotics advancing products. Establishing standardized guidelines transparent practices is essential, requiring collaboration among regulatory bodies, industry stakeholders, scientific community. underscores importance innovation developing friendly ,” super fermentation, assessments. prospects beverages rely refining elements adapting to emerging advancements. Ultimately, empowering consumers with accurate information, fostering innovation, maintaining stringent standards will shape trusted beneficial components a health‐conscious society. Probiotic‐based often infused LABs, designed health.

Language: Английский

---

Evolutionary medicine and bioastronautics: an innovative approach in addressing adverse mental health effects to astronauts during long term space missions

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: April 24, 2025

Although evolutionary medicine has produced several novel insights for explaining prevalent health issues, it yet to sufficiently address possible adverse mental effects of humans during long-term space missions While applications have increased over the past 20 years, there is scope integration in new branch called bioastronautics, which analyses on human bodies when outer space. Evolutionary principles may explain what kinds environments increase risks astronauts, both short and long term; secondly, provide a more informed understanding mismatch between terrestrial astronauts exist. This information assist developing frameworks improving future colonists. Consequently, this paper will focus some major mismatches currently confronting astronauts’ health, with an aim improve medical knowledge. It also therapeutic countermeasures based reducing astronauts.

Language: Английский

---

Harnessing Probiotics: Emerging Strategies for Health and Disease Management

Indian Journal of Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Language: Английский

---

Management of asthma using probiotics

Published: Feb. 20, 2024

Asthma is one of the most common respiratory diseases in humans throughout world. The illness continues to be prevalent cause morbidity and affects both adults children. mainly caused by microbes, especially species Aspergillus. It causes continuous irritation distracts mental attention patient, leading physical weakness depression resulting immune-compromised conditions. Asthmatic patients need careful treatment. Taking into account its major effects on patients’ quality life, challenging nature therapy, side novel therapeutic strategies that influence clinical course asthma are required considered before finally deciding Children with wheezing frequently sustained a type-2 immune response. In addition, people can identified presence digestive tract dysbiosis. Therefore, oral probiotics could used as an additional asthmatic medication manage asthma, but decision should constantly monitored specialized persons. During last two decades, importance treatment various ailments has been realized several researches being conducted find out impact healthy gut microbiome management including asthma.

Language: Английский

---

The Impact of Early-Life Cecal Microbiota Transplantation on Social Stress and Injurious Behaviors in Egg-Laying Chickens

Microorganisms, Journal Year: 2024, Volume and Issue: 12(3), P. 471 - 471

Published: Feb. 26, 2024

Injurious behaviors (i.e., aggressive pecking, feather and cannibalism) in laying hens are a critical issue facing the egg industry due to increased social stress related health welfare issues as well economic losses. In humans, stress-induced dysbiosis increases gut permeability, releasing various neuroactive factors, causing neuroinflammation neuropsychiatric disorders via microbiota-gut-brain axis, consequently increasing frequency intensity of aggression violent behaviors. Restoration imbalanced microbial composition has become novel treatment strategy for mental illnesses, such depression, anxiety, bipolar disorder, schizophrenia, impulsivity, compulsivity. A similar function modulating following challenge may be present egg-laying chickens. The avian cecum, multi-purpose organ, greatest bacterial biodiversity (bacterial diversity, richness, species composition) along gastrointestinal tract, with vitally important functions maintaining physiological behavioral homeostasis, especially during periods stress. To identify effects microbiome on injurious chickens, we have designed tested transferring cecal contents from two divergently selected inbred chicken lines stress-related recipient chicks commercial layer strain. This article reports outcomes multi-year study modification microbiota reduce An discovery this corpus experiments is that chickens can reduced or inhibited through modifying brain serotonergic activities gut-brain without donor-recipient genetic effects.

Language: Английский

---

Probiotics and Commensal Bacteria Metabolites Trigger Epigenetic Changes in the Gut and Influence Beneficial Mood Dispositions

Microorganisms, Journal Year: 2023, Volume and Issue: 11(5), P. 1334 - 1334

Published: May 18, 2023

The effect of the intestinal microbiome on gut–brain axis has received considerable attention, strengthening evidence that bacteria influence emotions and behavior. colonic is important to health pattern composition concentration varies extensively in complexity from birth adulthood. That is, host genetics environmental factors are complicit shaping development achieve immunological tolerance metabolic homeostasis birth. Given perseveres maintain gut throughout life cycle, epigenetic actions may determine beneficial outcomes mood. Probiotics postulated exhibit a range positive benefits including immunomodulating capabilities. Lactobacillus Bifidobacterium genera found intestines so far, afforded by ingesting such as these probiotics people with mood disorders have varied efficacy. Most likely, efficacy probiotic at improving multifactorial dependency, relying namely several include agents used, dose, dosing, pharmacotherapy characteristics underlying luminal microbial environment (e.g., dysbiosis). Clarifying pathways linking improvements help identify dependent upon. Adjunctive therapies for could, through DNA methylation molecular mechanisms, augment active cohort endow its mammalian critical co-evolutionary redox signaling interactions, embedded bacterial genomes, turn can enhance dispositions.

Language: Английский

---

Microbiota intestinal, probióticos y su relación con el trastorno depresivo mayor: una revisión bibliográfica

Revista San Gregorio, Journal Year: 2024, Volume and Issue: 1(58), P. 111 - 118

Published: June 30, 2024

El trastorno depresivo mayor (TDM) ha ganado relevancia en los últimos años, ya que es una de las principales causas discapacidad a nivel mundial y ejerce un impacto significativo la vida diaria quienes lo experimentan. La relación entre disbiosis intestinal el TDM surgido como componente crucial ámbito salud mental. microbiota intestinal, abarca amplia diversidad microorganismos, establece conexión bidireccional con través del eje microbiota-intestino-cerebro, neuroinflamación alteración función cerebral. presente trabajo tuvo objetivo, analizar problemas equilibrio microorganismos intestino (fenómeno conocido “disbiosis”) TDM. Se adoptó enfoque cualitativo combinó análisis bibliográfico descriptivo, priorizando fuentes primarias psicología, neurociencia microbiología. examinaron investigaciones inglés español desde 2019 hasta 2023 utilizando motores búsqueda bases datos reconocidas. En este contexto, se observó uso probióticos vuelto cada vez más relevante parte tratamiento complementario para Los probióticos, Lactobacillus plantarum DP189 bacteria Roseburia intestinalis, ejercen positivo integridad barrera hematoencefálica producción neurotransmisores. revisión destaca papel prometedora utilidad complementario. Esto sugiere nuevas perspectivas terapéuticas subraya

---

Gut dysbiosis mediates the association between antibiotic exposure and chronic disease

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 6, 2024

Antibiotics are safe, effective drugs and continue to save millions of lives prevent long-term illness worldwide. A large body epidemiological, interventional experimental evidence shows that exposure antibiotics has negative effects on human health. We reviewed the literature data links between antibiotic exposure, gut dysbiosis, chronic disease (notably with regard “developmental origins health disease” (“DOHaD”) approach). Molecular biology studies show systemic administration infants a rapid onset but also often long-lasting impact microbial composition gut. Along other environmental factors (e.g., an unhealthy “Western” diet sedentary behavior), induce which can be defined as disruption previously stable, functionally complete microbiota. Gut dysbiosis many harmful Associations early-life have been reported for diseases, including inflammatory bowel disease, celiac some cancers, metabolic diseases (obesity type 2 diabetes), allergic autoimmune disorders, atherosclerosis, arthritis, neurodevelopmental, neurodegenerative neurological diseases. In mechanistic terms, influences through direct mucosal immune pathways, plus wide array or indirect short-chain fatty acids, enteric nervous system, peristaltic motility, production hormones neurotransmitters, loss intestinal barrier integrity leakage pro-inflammatory endotoxin lipopolysaccharide into circulation). To mitigate probiotics in patients is (but not always) associated positive clinical markers scores) biomarkers inflammation activation. Meta-analyses complicated by differences probiotic composition, dose level, treatment duration, large, randomized, controlled trials lacking areas. view critical importance deciding whether prescribe (especially children), we suggest DOHaD concept logically extended “gastrointestinal (“GOHaD”) even “microbiotic (“MOHaD”).

Language: Английский

---