Psychobiotic potential of Lactiplantibacillus plantarum: Current perspective in neurodegeneration and geriatric therapies DOI Creative Commons
Nishant Gupta, Ashok Agarwal,

M. Al-Dossari

et al.

Brain Behavior and Immunity Integrative, Journal Year: 2023, Volume and Issue: 5, P. 100038 - 100038

Published: Dec. 9, 2023

Management of neurodegenerative disease can be challenging when there is limited access to effective treatment options. Recent studies indicate that human gut microbiota may influence diseases and the aging process. Gut dysbiosis one exacerbating factors associated with interrupted gut-brain axis diseases. According preclinical evidence, targeting by probiotic Lactiplantibacillus plantarum (LBP) a promising approach improve altered several hallmarks. LBP has been popular model but its psychobiotic potential little understood so far. modulate maintain intestinal homeostasis, resulting in induced levels SCFAs, GABA, other neurotransmitter. LBP-associated signaling agents induce (GBA) stimulate intracellular antioxidant anti-inflammatory pathways nerve cells. LBP-based supplements reduce various hallmarks such as β-amyloid formation, tau phosphorylation, microgliosis, infiltrated blood-brain barrier, neuroinflammation, morphology grey matter animal models Alzheimer's disease, autism spectrum disorder, multiple sclerosis, Parkinson's disease. This review suggests an important agent perturbed administration enhance existed treatment, especially geriatric conditions.

Language: Английский

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases DOI Creative Commons
Jian Sheng Loh, Wen Qi Mak, Li Tan

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Feb. 16, 2024

Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management

Language: Английский

Citations

219
Amelioration of obesity and inflammation by polysaccharide from unripe fruits of raspberry via gut microbiota regulation DOI
Yuzhe Huang,

Jingjing Hu,

Qijun Xia

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129825 - 129825

Published: Feb. 1, 2024

Language: Английский

Citations

15
The gut microbiota–brain axis in neurological disorders DOI Creative Commons

Mingming You,

Nan Chen,

Yuanyuan Yang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 20, 2024

Abstract Previous studies have shown a bidirectional communication between human gut microbiota and the brain, known as microbiota–gut–brain axis (MGBA). The MGBA influences host's nervous system development, emotional regulation, cognitive function through neurotransmitters, immune modulation, metabolic pathways. Factors like diet, lifestyle, genetics, environment shape composition together. Most research explored how regulates host physiology its potential in preventing treating neurological disorders. However, individual heterogeneity of microbiota, strains playing dominant role diseases, interactions these microbial metabolites with central/peripheral systems still need exploration. This review summarizes driving neurodevelopmental disorders (autism spectrum disorder attention deficit/hyperactivity disorder), neurodegenerative diseases (Alzheimer's Parkinson's disease), mood (anxiety depression) recent years discusses current clinical preclinical microbe‐based interventions, including dietary intervention, probiotics, prebiotics, fecal transplantation. It also puts forward insufficient on provides framework for further

Language: Английский

Citations

15
Gut Microbiota-Based Interventions for Parkinson’s Disease: Neuroprotective Mechanisms and Current Perspective DOI
Deepak Kumar, Mahendra Bishnoi, Kanthi Kiran Kondepudi

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Language: Английский

Citations

1
A glucan from Ganoderma lucidum: structural characterization and the anti-inflammatory effect on Parkinson's Disease via regulating dysfunctions of intestinal microecology and inhibiting TLR4/MyD88/NF-κB signaling pathway DOI
Li Chen,

Yanxin Ling,

Jiaxin Sun

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 343, P. 119446 - 119446

Published: Feb. 4, 2025

Language: Английский

Citations

1
Neuroprotective Effects of Bifidobacterium animalis subsp. lactis NJ241 in a Mouse Model of Parkinson’s Disease: Implications for Gut Microbiota and PGC-1α DOI Creative Commons

Yuxuan Dong,

Yueyan Qi,

Jinhu Chen

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(10), P. 7534 - 7548

Published: Feb. 26, 2024

Intestinal dysbiosis plays a critical role in the pathogenesis of Parkinson's disease (PD), and probiotics have emerged as potential modulators central nervous system function through microbiota-gut-brain axis. This study aimed to elucidate anti-inflammatory effects underlying mechanisms probiotic strain Bifidobacterium animalis subsp. lactis NJ241 (NJ241) mouse model PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The impact was comprehensively assessed mice behavioral tests, immunofluorescence, Western blotting, enzyme-linked immunosorbent assay (ELISA), 16S rRNA sequencing, short-chain fatty acid (SCFA) detection. exhibited notable efficacy mitigating MPTP-induced weight loss, gastrointestinal dysfunction, deficits mice. Furthermore, it demonstrated protected against dopaminergic neuron death inhibited activation glial cells substantia nigra (SN). ability normalized intestinal microbiota elevate SCFA levels Additionally, reversed reductions colonic GLP-1 expression GLP-1R PGC-1α SN. Notably, antagonists partially inhibitory on In summary, exerts neuroprotective effect neuroinflammation enhancing activating nigral signaling. These findings provide rationale for exploration development probiotic-based therapeutic strategies PD.

Language: Английский

Citations

7
A neurotherapeutic approach with Lacticaseibacillus rhamnosus E9 on gut microbiota and intestinal barrier in MPTP-induced mouse model of Parkinson’s disease DOI Creative Commons
Büşra Aktaş, Belma Aslım, Deniz Ateş

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 4, 2024

Abstract The gut microbiota plays a crucial role in neural development and progression of disorders like Parkinson’s disease (PD). Probiotics have been suggested to impact neurodegenerative diseases via gut-brain axis. This study aims investigate the therapeutic potential Lacticaseibacillus rhamnosus E9, high exopolysaccharide producer, on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced mouse model PD. C57BL/6 mice subjected MPTP were fed L. E9 for fifteen days sacrificed after last administration. Motor functions determined by open-field, catalepsy, wire-hanging tests. ileum brain tissues collected ELISA, qPCR, immunohistochemistry analyses. cecum content was obtained analysis. supplementation alleviated MPTP-induced motor dysfunctions accompanied decreased levels striatal TH dopamine. also reduced level ROS striatum DAT expression while increasing DR1. Furthermore, improved intestinal integrity enhancing ZO-1 Occludin reversed dysbiosis induced MPTP. In conclusion, deficits damage as well barrier modulating PD mice. These findings suggest that holds managing through

Language: Английский

Citations

6
Emerging therapeutic role of gut microbial extracellular vesicles in neurological disorders DOI Creative Commons
Bowen Sun, Harshal Sawant, Alip Borthakur

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Aug. 9, 2023

Extracellular vesicles (EVs) serve as cell-to-cell and inter-organ communicators by conveying proteins nucleic acids with regulatory functions. Emerging evidence shows that gut microbial-released EVs play a pivotal role in the gut-brain axis, bidirectional communication, crosstalk between brain. Increasing pre-clinical clinical suggests bacteria-released are capable of eliciting distinct signaling to brain ability cross blood–brain barrier, exerting function on cells such neurons, astrocytes, microglia, via their abundant diversified protein acid cargo. Conversely, derived from certain species bacteria, particularly commensals probiotic properties, have recently been shown confer therapeutic effects various neurological disorders. Thus, bacterial may be both cause therapy for neuropathological complications. This review marshals basic, clinical, translational studies significantly contributed our up-to-date knowledge potential microbial-derived treating disorders, including strokes, Alzheimer’s Parkinson’s disease, dementia. The also discusses newer insights recent focused developing superior microbial genetic manipulation and/or dietary intervention.

Language: Английский

Citations

15
The Interaction Between Nutraceuticals and Gut Microbiota: a Novel Therapeutic Approach to Prevent and Treatment Parkinson’s Disease DOI

Liyan Yao,

Yong Yang,

Xiaowei Yang

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(11), P. 9078 - 9109

Published: April 8, 2024

Language: Английский

Citations

4
Electroacupuncture improves gastrointestinal motility through a central-cholinergic pathway-mediated GDNF releasing from intestinal glial cells to protect intestinal neurons in Parkinson's disease rats DOI Creative Commons
Can Zhang, Tan Chen,

Mingwei Fan

et al.

Neurotherapeutics, Journal Year: 2024, Volume and Issue: 21(4), P. e00369 - e00369

Published: May 14, 2024

Constipation symptoms of Parkinson's disease (PD) seriously reduce the quality life patients and aggravate development disease, but current treatment options still cannot alleviate progress constipation. Electroacupuncture (EA) is a new method for constipation, which can effectively treat constipation in PD patients. However, specific regulatory mechanisms EA remain unclear. The aim this study to investigate therapeutic effect on rats its mechanism. A rotenone (ROT)-induced gastrointestinal motility disorder model was used simulate pathological process PD. results showed that could promote peristalsis, α-synuclein accumulation substantia nigra colon colonic injury after ROT administration. Mechanistically, activation central-cholinergic pathway increases acetylcholine release colon. At same time, up-regulated co-expression enteric glial cells (EGCs) α7 nicotinic receptor (α7nAChR). increased expression choline acetyltransferase (ChAT), neuronal nitric oxide synthase (nNOS), tyrosine hydroxylase (TH) rats. Further mechanistic studies cell-derived neurotrophic factor (GDNF), GFRa1 p-AKT tissues. present confirmed upregulates α7nAChR through mechanism GDNF from EGCs, thereby protecting intestinal neurons improving motility.

Language: Английский

Citations

4