Stimulation of Emodin from Aloe Vera on Protein Kinase PIM1 in the Central Nervous System Through In Silico Analysis DOI Open Access
Rahadian Zainul,

Rismi Verawati,

Ritbey Ruga

et al.

Pharmacognosy Journal, Journal Year: 2023, Volume and Issue: 15(4), P. 587 - 592

Published: Aug. 15, 2023

This study aims to investigate the potential of Emodin, a compound found in Aloe vera, as stimulator Protein Kinase PIM1 central nervous system using an in-silico approach. The research method involves use software such Pymol, Pyrex, Plus, and Lepinski Rule. Firstly, protein structure target was obtained from database prepared Pymol. Next, molecular Emodin imported into Pyrex subjected geometry optimization. Docking analysis Pymol performed predict interactions between PIM1. Additionally, RMSD conducted evaluate stability protein-ligand complex formed. docking results showed that exhibited significant Binding Affinity, with values -8.4, -8.3, -8.2, indicating strong affinity indicated complex, 0, 1.101, 1.122. Furthermore, Plus revealed presence through hydrogen bonding hydrophobic contacts. Rule demonstrated fulfilled several important criteria drug design, including weight 270, 3 bond donors, 5 acceptors, log p value 1.887220, molar reactivity 64.480385. These findings indicate provide foundation for development therapies system-related disorders.

Language: Английский

Terpenoid-Mediated Targeting of STAT3 Signaling in Cancer: An Overview of Preclinical Studies DOI Creative Commons
Fahad Khan, Pratibha Pandey, Meenakshi Verma

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(2), P. 200 - 200

Published: Feb. 7, 2024

Cancer has become one of the most multifaceted and widespread illnesses affecting human health, causing substantial mortality at an alarming rate. After cardiovascular problems, condition a high occurrence rate ranks second in terms mortality. The development new drugs been facilitated by increased research deeper understanding mechanisms behind emergence advancement disease. Numerous preclinical clinical studies have repeatedly demonstrated protective effects natural terpenoids against range malignancies. potential bioactive investigated sources for their chemopreventive chemoprotective properties. In practically all body cells, signaling molecule referred to as signal transducer activator transcription 3 (STAT3) is widely expressed. that STAT3 regulates its downstream target genes, including Bcl-2, Bcl-xL, cyclin D1, c-Myc, survivin, promote growth differentiation, cell cycle progression, angiogenesis, immune suppression addition chemotherapy resistance. Researchers viewed primary cancer therapy because crucial involvement formation. This primarily focuses on directly indirectly preventing expression tumor cells. By explicitly targeting both vitro vivo settings, it possible explain effect malignant this study, we provide complete overview transduction processes, carcinogenesis, related persistent activation. article also thoroughly summarizes inhibition certain terpenoid phytochemicals, which strong efficacy several models.

Language: Английский

Citations

10
Valorisation of fruit waste for harnessing the bioactive compounds and its therapeutic application DOI

Ritika Arora,

Rizwana,

Saroj Shukla

et al.

Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 144, P. 104302 - 104302

Published: Dec. 17, 2023

Language: Английский

Citations

17
HR-MS-based bioactive profiling of green Banana flour and millets-based Murukku snack DOI

Tarak Nath Saha,

Manish Singh, Dinesh Chandra

et al.

Food and Humanity, Journal Year: 2025, Volume and Issue: unknown, P. 100511 - 100511

Published: Jan. 1, 2025

Language: Английский

Citations

0
Molecular Insights in the Anticancer Activity of Natural Tocotrienols: Targeting Mitochondrial Metabolism and Cellular Redox Homeostasis DOI Creative Commons
Raffaella Chiaramonte,

Giulia Sauro,

Domenica Giannandrea

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 115 - 115

Published: Jan. 20, 2025

The role of mitochondria as the electric engine cells is well established. Over past two decades, accumulating evidence has pointed out that, despite presence a highly active glycolytic pathway (Warburg effect), functional and even upregulated mitochondrial respiration occurs in cancer to meet need high energy biosynthetic demand sustain their anabolic growth. Mitochondria are also primary source intracellular ROS. Cancer maintain moderate levels ROS promote tumorigenesis, metastasis, drug resistance; indeed, once cytotoxicity threshold exceeded, trigger oxidative damage, ultimately leading cell death. Based on this, metabolic functions generation considered attractive targets synthetic natural anticancer compounds. Tocotrienols (TTs), specifically δ- γ-TT isoforms, vitamin E-derived biomolecules widely shown possess striking properties since they regulate several molecular pathways. Herein, we provide for first time an overview reprogramming redox homeostasis perturbation occurring cells, highlighting involvement TTs. This sheds light use these compounds promising preventive or therapeutic approach novel strategies.

Language: Английский

Citations

0
Age-Related Macular Degeneration Pathophysiology and Therapeutic Potential of Tocotrienols: An Update DOI
Muhammad Zulfiqah Sadikan, Lidawani Lambuk,

Nur Hidayah Reshidan

et al.

Journal of Ocular Pharmacology and Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Age-related macular degeneration (AMD) poses a significant threat to visual health among the elderly, necessitating urgent preventive measures as global population ages. Extensive research has implicated oxidative stress (OS)-induced retinal damage primary contributor AMD pathogenesis, prompting investigations into potential therapeutic interventions. Among various nutrients studied for their in risk reduction, antioxidants have shown promise, with initial findings from Age-Related Eye Disease Study suggesting correlation between antioxidant supplementation and decreased progression. This article explores scientific foundation supporting efficacy of tocotrienol-rich fraction (TRF) viable candidate slowing progression, based on interventional studies. is characterized by OS, inflammation, dysregulated lipid metabolism, angiogenesis, all which TRF purportedly addresses through its potent anti-inflammatory, lipid-lowering, antiangiogenic, properties. The review underscores TRF's promising attributes, aiming deepen understanding pathogenesis advocate TRF-based pharmacological interventions enhance outcomes. Given pressing need effective treatments, represents avenue intervention, offering hope improved vision outcomes enhanced quality life individuals affected this debilitating condition.

Language: Английский

Citations

0
A facile and simple synthesis of a cytotoxic tocotrienol-based nanoemulsion against MCF-7 and A549 cancer cell lines DOI
A’liyatur Rosyidah, Riyona Desvy Pratiwi, Sjaikhurrizal El Muttaqien

et al.

Colloid & Polymer Science, Journal Year: 2024, Volume and Issue: 302(7), P. 1025 - 1035

Published: March 26, 2024

Language: Английский

Citations

3
Targeting the crosstalk of epigenetic modifications and immune evasion in nasopharyngeal cancer DOI
Chin-King Looi, Lian Chee Foong, Felicia Fei‐Lei Chung

et al.

Cell Biology and Toxicology, Journal Year: 2023, Volume and Issue: 39(6), P. 2501 - 2526

Published: Sept. 27, 2023

Language: Английский

Citations

7
Polyethylene glycol-phospholipid functionalized single-walled carbon nanotubes for enhanced siRNA systemic delivery DOI Creative Commons

Yuen-Fen Tan,

Ling‐Wei Hii, Wei‐Meng Lim

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 3, 2024

Small interfering RNAs (siRNA) technology has emerged as a promising therapeutic tool for human health conditions like cancer due to its ability regulate gene silencing. Despite FDA-approved, their delivery remains localized and limiting systemic use. This study used single-walled carbon nanotubes (SWNTs) functionalized with polyethylene glycolated (PEGylated) phospholipids (PL-PEG) derivatives siRNA delivery. We developed an vehicle (SWNT-siRNA) by conjugating SWNT PL-PEG containing either amine (PA) or maleimide (MA). The lower molecular weight of PA produced the SWNT-siRNA conjugate system highest stability high loading quantity. delivered panel tumour cell lines different organs (i.e. HeLa, H1299 MCF-7) non-cancerous embryonic kidney 293 cells (HEK293T) biocompatibility low toxicity. cellular uptake conjugates epithelial was found be energy dependent. Importantly, presence P-glycoprotein, marker drug resistance, did not inhibit SWNT-mediated Mouse xenograft model further confirmed potential significant knock-down without signs acute These findings pave way therapy applications using SWNTs vehicles.

Language: Английский

Citations

2
Anticancer Activity of Delta-Tocotrienol in Human Hepatocarcinoma: Involvement of Autophagy Induction DOI Open Access
Marina Montagnani Marelli, Chiara Macchi, Massimiliano Ruscica

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(15), P. 2654 - 2654

Published: July 26, 2024

(1) Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer. Surgical resection, tumor ablation, and transplantation are curative treatments indicated for early-stage HCC. The management intermediate advanced stages pathology based on use systemic therapies which often show important side effects. Vitamin E-derivative tocotrienols (TTs) play antitumoral properties in different tumors. Here, we analyzed activity delta-TT (δ-TT) HCC human cell lines. (2) We ability δ-TT to trigger apoptosis, induce oxidative stress, autophagy, mitophagy HepG2 line. evaluated correlation between activation autophagy with death. (3) data obtained demonstrate that exerts an antiproliferative proapoptotic effect cells. Furthermore, induces release mitochondrial ROS causes a structural functional alteration mitochondria compatible fission process. Finally, triggers selective process removing dysfunctional mitochondria. Inhibition reversed cytotoxic action δ-TT. (4) Our results through could represent potential new approach treatment

Language: Английский

Citations

1
Assessment of the anti‐inflammatory and anti‐glycemic properties of Royal Jelly and Tocotrienol‐rich fraction in an experimental study: Does irisin mediate these effects? DOI Creative Commons
Naimeh Mesri Alamdari, Pardis Irandoost, Neda Roshanravan

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(10), P. 7533 - 7543

Published: July 29, 2024

Abstract Irisin, a novel adipomyokine, has been proposed to be therapeutic agent against obesity‐related metabolic disease. Royal Jelly (RJ) and tocotrienol‐rich fraction (TRF) are suggested promote obesity its related problems through potential mutual mechanistic pathways. This investigation intended evaluate the glycemic inflammation‐promoting effects of RJ, TRF, their combinations synergic irisin action in obese rats induced by high‐fat diet (HFD) that underwent calorie restriction (CRD). Fifty HFD‐fed received following interventions: or RJ + TRF combination with CRD for eight consecutive weeks. After investigation, body weight, fasting blood sugar (FBS), irisin, insulin, C‐reactive protein (CRP), interleukin‐6 (IL‐6), interleukin‐1 beta (IL‐1β), leptin, adiponectin, insulin resistance (IR) were assessed. 8 weeks treatment, significant weight reduction was noticed ( p < .001), although this not considerable TRF‐treated rats. supplementation markedly elevated concentrations .05), but did not. Glycemic indices, inflammatory indices including IL‐1β CRP levels, leptin significantly decreased after added .05). According mediational analysis results, mediated promoting on hemostasis. Based results nutrients have improve disorders. research suggests exerts beneficial regulatory irisin.

Language: Английский

Citations

1