Targeting Sodium in Heart Failure DOI Open Access
Filippos Triposkiadis, Αndrew Xanthopoulos, John Skoularigis

et al.

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(10), P. 1064 - 1064

Published: Oct. 17, 2024

A dominant event determining the course of heart failure (HF) includes disruption delicate sodium (Na+) and water balance leading to retention edema formation. Although incomplete decongestion adversely affects outcomes, it is unknown whether interventions directly targeting (Na+), such as strict dietary restriction, intravenous hypertonic saline, diuretics, reverse this effect. As a result, imperative implement (Na+)-targeting in selected HF patients with established congestion on top quadruple therapy angiotensin receptor neprilysin inhibitor, β-adrenergic blocker, mineralocorticoid antagonist, glucose cotransporter 2 which dramatically improves outcomes. The limited effectiveness treatments may be partly due fact that current metrics severity have capacity foreseeing averting episodes guiding treatments, often leads dysnatremias, affecting Recent evidence suggests spot urinary measurements used guide monitor both chronic acute HF. Further, classical (2)-compartment model storage has been displaced by (3)-compartment emphasizing non-osmotic accumulation chiefly skin. 23(Na+) magnetic resonance imaging (MRI) enables accurate reliable quantification tissue (Na+). Another promising approach enabling monitoring based wearable devices employing ion-selective electrodes for electrolyte detection, including (Cl–). Undoubtably, further studies using 23(Na+)-MRI technology sensors are required learn more about clinical significance (Na+)-related mechanisms morbidity mortality

Language: Английский

The potential effect of natural antioxidants on endothelial dysfunction associated with arterial hypertension DOI Creative Commons
Rosamaria Caminiti, Cristina Carresi, Rocco Mollace

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 2, 2024

Arterial hypertension represents a leading cause of cardiovascular morbidity and mortality worldwide, the identification effective solutions for treating early stages elevated blood pressure (BP) is still relevant issue risk prevention. The pathophysiological basis occurrence BP onset arterial have been widely studied in recent years. In addition, consistent progress development novel, powerful, antihypertensive drugs their appropriate applications controlling increased our potential successfully managing disease states characterized by abnormal pressure. However, mechanisms responsible disruption endogenous contributing to maintenance within normal range are yet be fully clarified. Recently, evidence has shown that several natural antioxidants containing active ingredients originating from plant extracts, used alone or combination, may represent valid solution counteracting hypertension. particular, there show enhance viability endothelial cells undergoing oxidative damage, an effect could play crucial role events accompanying present review aims reassess stress on dysfunction progression covering unmet needs treatment such diseases.

Language: Английский

Citations

12
Hyaluronic Acid Role in Biomaterials Prevascularization DOI
Julia Simińska‐Stanny, Daria Podstawczyk, Christine Delporte

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Abstract Tissue vascularization is a major bottleneck in tissue engineering. In this review, the state of art on intricate role hyaluronic acid (HA) angiogenesis explored. HA plays twofold angiogenesis. First, when released as free polymer extracellular matrix (ECM), acts signaling molecule triggering multiple cascades that foster smooth muscle cell differentiation, migration, and proliferation thereby contributing to vessel wall thickening. Simultaneously, bound plasma membrane pericellular space functions block, participating formation. Starting with origins native vascular tissues, approaches aimed at achieving vivo are reviewed. The significance molecular weight (MW) challenges associated utilizing engineering (VTE) conscientiously addressed. review finally focuses thorough examination comparison diverse strategies adopted harness benefits bioengineered materials. By providing nuanced perspective multifaceted angiogenesis, contributes ongoing discourse advances collective understanding optimizing processes assisted by functional biomaterials.

Language: Английский

Citations

10
Stick to the Script: How Endomucin Keeps the Glycocalyx in Line DOI
Ronald K. McMillan, Blanca Rodríguez, Annet Kirabo

et al.

Circulation Research, Journal Year: 2025, Volume and Issue: 136(1), P. 75 - 77

Published: Jan. 2, 2025

Language: Английский

Citations

0
Sodium, the Vascular Endothelium, and Hypertension: A Narrative Review of Literature DOI

Jackeline Flores,

Kenneth Nugent

Cardiology in Review, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

The vascular endothelium and its endothelial glycocalyx contribute to the protection of cells from exposure high levels sodium help these structures maintain normal function by regulating permeability due buffering effect. has negative surface charges that bind limit entry into interstitial space. High can disrupt this barrier allow movement extravascular fluid. This generate reactive oxygen species inhibit nitric oxide production. leads vasospasm increases intravascular pressures. Overtime remodeling occurs, changes anatomy blood vessels, their intrinsic stiffness, response vasodilators results in hypertension. Patients with increased salt sensitivity are potentially at more risk for sequence events. Studies on degradation provide insight pathogenesis clinical disorders involvement, but there is limited information available context higher concentrations sodium. Data intake imbalance between have been obtained experimental studies insights possible outcomes humans. current western diet above recommended led assessment sensitivity, which used different populations could become a practical tool evaluate patients. would focused recommendations regarding intake. review will consider structure endothelium, components, effect it, use test mini.

Language: Английский

Citations

0
Association of salt added to food with risk of cardiovascular diseases: A 2-sample Mendelian randomization study DOI Creative Commons
Shaokang Wang, Yixin Wang, Xiaoying Lü

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(11), P. e41543 - e41543

Published: March 14, 2025

Salt added to food is believed potentially influence the risk of cardiovascular diseases (CVD), however, more evidence needs further verification. Here, we conducted a 2-sample Mendelian randomization (MR) study systematically investigate associations salt with 11 types in general population. The primary MR analysis adopts inverse-variance weighting (IVW) method, complemented by ancillary analyses utilizing IVW (fixed effects), weighted medium, maximum likelihood, and penalized median methodologies. main pleiotropy genetic variation sensitivity were correspondingly applied test reliability results, MR-Egger are core evaluation methods. Notably, genetically predicted demonstrates causal vein thromboembolism (IVW odds ratio [OR]: 1.0084, 95% confidence interval [CI]: 1.0024-1.0143, P = .0056), atrial fibrillation flutter OR: 1.3176, CI: 1.0154-1.7098, .0380), ischemic stroke 1.1852, 1.0092-1.3918, .0383) peripheral artery disease 1.0040, 1.0015-1.0065, .0016). These findings provide valuable insights that may guide development targeted prevention strategies interventions focused on dietary habits context diseases.

Language: Английский

Citations

0
Uteroplacental microvascular remodeling in health and disease DOI Open Access
Ruizhi Li,

Lei Ma,

Yan Geng

et al.

Acta Physiologica, Journal Year: 2025, Volume and Issue: 241(5)

Published: March 29, 2025

The microvascular system is essential for delivering oxygen and nutrients to tissues while removing metabolic waste. During pregnancy, the uteroplacental undergoes extensive remodeling meet increased demands of fetus. Key adaptations include vessel dilation increases in vascular volume, density, permeability, all which ensure adequate placental perfusion maintaining stable maternal blood pressure. Structural functional abnormalities microvasculature are associated with various gestational complications, posing both immediate long-term risks health mother infant. In this review, we describe changes microvessels during discuss pathogenic mechanisms underlying diseases such as preeclampsia, fetal growth restriction, diabetes, summarize current clinical research approaches monitoring health. We also provide an update on models complications explore solutions several unresolved challenges. With advancements techniques, anticipate significant progress understanding managing these diseases, ultimately leading new therapeutic strategies improve

Language: Английский

Citations

0
Pulmonary Microvascular Endothelial Glycocalyx Degradation as a Key Driver in COPD Progression and Its Protection by Tongxinluo DOI

Jing Guo,

Jui‐Sheng Sun,

Mingyu Xiong

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156878 - 156878

Published: May 1, 2025

Language: Английский

Citations

0
Erythrocyte glycocalyx sensitivity to sodium is associated with salt sensitivity of blood pressure in women but not men DOI Creative Commons
Sepiso K. Masenga, Benson M. Hamooya, Kaushik P. Patel

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: March 8, 2024

Background While salt sensitivity of blood pressure (SSBP) is a risk factor for hypertension, end-organ damage and death, most studies are conducted in western countries White people. We previously found that the prevalence SSBP Blacks living Sub-Saharan Africa as high 75–80% like what has been reported west. Erythrocyte glycocalyx to sodium (eGCSS), marker sodium-induced erythrocyte vascular endothelial thought be related perturbations associated with intake. hypothesized correlates eGCSS differently men women Black Methods cross sectional study using data from our recent clinical trial Livingstone University Teaching Hospital among 117 normotensive young adults. used “salt test” determine an immediate pressor response oral (IPROS) diagnosis SSBP. Results The proportion males were equal females median age (interquartile range) participants was 29 (22–45) years. scores higher salt-resistant compared salt-sensitive males. correlated negatively (AOR 0.98, 95% CI 0.97–0.99, p = 0.008), however, this relationship driven by female sex abrogated male sex. Although elevations exhibited sustained bimodal pattern both sexes, males, systolic diastolic never returned baseline during time course it did females. Conclusion In study, black but not dietary significantly women. These results suggest tend have disruption acute load, implying changes may directly glycocalyx. Our findings novel mechanism linking potential implications differences salt-induced cardiovascular disease. Clinical registration : https://clinicaltrials.gov/ , identifier [NCT04844255].

Language: Английский

Citations

3
ADAMTS5 Promotes Permeability of the Blood-Brain Barrier during Treponema pallidum Subspecies pallidum Invading the Central Nervous System DOI

Zuoxi Chen,

Fangzhi Du, Ruihua Zhang

et al.

ACS Infectious Diseases, Journal Year: 2024, Volume and Issue: 10(4), P. 1222 - 1231

Published: March 27, 2024

The pathogenesis of neurosyphilis remains unclear. A previous study found a noteworthy up-regulation disintegrin and metalloproteinase with thrombospondin type 1 motif 5 (ADAMTS5) gene in human brain microvascular endothelial cells cocultured

Language: Английский

Citations

3
High salt intake and HIV infection on endothelial glycocalyx shedding in salt-sensitive hypertension DOI Creative Commons
Sepiso K. Masenga, Situmbeko Liweleya, Annet Kirabo

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: July 16, 2024

The endothelial glycocalyx is closely associated with various physiological and pathophysiological events. Significant modification of the an early process in pathogenesis cardiovascular disease. High dietary salt HIV infection damages causing dysfunction increasing risk for salt-sensitive hypertension two factors, are critical independent predictors disease often synergize to exacerbate accelerate pathogenesis. Salt-sensitive more common among people living disease, stroke, heart attack even death. However, underlying mechanisms linking damage lacking. Yet, both infection/treatment linked development hypertension. Moreover, majority individuals globally, consume than recommended burden especially sub-Sahara Africa disproportionately high. In this review, we have discussed missing link between high shedding We further elaborated role played by treatment modifying integrity contribute

Language: Английский

Citations

2