Dietary Interventions and Physical Activity as Crucial Factors in the Prevention and Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 217 - 217

Published: Jan. 16, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic worldwide and affects nearly 30% of adult population 10% pediatric population. It estimated that this number will double by 2030. MASLD one leading causes hepatocellular carcinoma, cirrhosis, transplantation, as well a significant risk factor for cardiovascular mortality. Due to ever-increasing patients, long-term asymptomatic course disease, serious complications, lack preventive programs, insufficient awareness among patients doctors themselves, growing interdisciplinary problem real challenge modern medicine. The main cause an inappropriate lifestyle—inadequate nutrition physical activity, which lead various components metabolic syndrome. Lifestyle changes—appropriate diet, weight reduction, systematic activity—are also basis prevention treatment MASLD. Hence, in recent years, so much importance has been attached lifestyle medicine, non-pharmacological diseases. narrative review presents possible therapeutic options management best documented available diets used were discussed, focusing on benefits drawbacks Mediterranean, high-protein, ketogenic, intermittent fasting diets. In addition, recommendations regarding activity are summarized.

Language: Английский

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Metabolic Effects of Ketogenic Diets: Exploring Whole-Body Metabolism in Connection with Adipose Tissue and Other Metabolic Organs

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7076 - 7076

Published: June 27, 2024

The ketogenic diet (KD) is characterized by minimal carbohydrate, moderate protein, and high fat intake, leading to ketosis. It recognized for its efficiency in weight loss, metabolic health improvement, various therapeutic interventions. KD enhances glucose lipid metabolism, reducing triglycerides total cholesterol while increasing high-density lipoprotein levels alleviating dyslipidemia. significantly influences adipose tissue hormones, key contributors systemic metabolism. Brown tissue, essential thermogenesis combustion, encounters modified UCP1 due dietary factors, including the KD. generates heat uncoupling electron transport during ATP synthesis. Browning of white elevates both brown tissues, a phenomenon encouraged Ketone oxidation depletes intermediates Krebs cycle, requiring anaplerotic substances, glucose, glycogen, or amino acids, efficiency. Methylation adipogenesis body's responses, with DNA methylation several genes linked loss stimulates FGF21, influencing stability via pathways. induces reduction muscle mass, potentially involving anti-lipolytic effects attenuating proteolysis skeletal muscles. Additionally, contributes neuroprotection, possesses anti-inflammatory properties, alters epigenetics. This review encapsulates signaling induced major organs.

Language: Английский

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Ketone bodies in cell physiology and cancer

AJP Cell Physiology, Journal Year: 2024, Volume and Issue: 326(3), P. C948 - C963

Published: Jan. 8, 2024

Ketogenic diets (KDs), fasting, or prolonged physical activity elevate serum ketone bodies (KBs) levels, providing an alternative fuel source for the brain and other organs. However, KBs play pleiotropic roles that go beyond their role in energy production. can act as signaling metabolites, influence gene expression, proteins' posttranslational modifications (PTMs), inflammation, oxidative stress. Here, we explore impact of on mammalian cell physiology, including aging tissue regeneration. We also concentrate cancer, given extensive evidence dietary approaches inducing ketosis, fasting-mimicking (FMDs) KDs, prevent cancer affect tumor progression.

Language: Английский

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Ketogenic Diets for Body Weight Loss: A Comparison with Other Diets

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 965 - 965

Published: March 10, 2025

With the prevalence of obesity and overweight increasing at an alarming rate, more researchers are focused on identifying effective weight loss strategies. The ketogenic diet (KD), used as a treatment in epilepsy management for over 100 years, is additionally gaining popularity method. Although its efficacy well documented, areas where it may be beneficial to other dietary approaches need carefully examined. objective this paper identify potential benefits KD alternative strategies based comprehensive literature review. It has been shown that bioenergetically efficient than strategies, inter alia owing effect curtailing hunger, improving satiety decreasing appetite (influence hunger hormones sensation hunger), inducing faster initial (associated with lower glycogen levels reduced water retention), controlling glycaemia insulinemia (directly attributable low-carbohydrate nature indirectly described). These effects accompanied by improved insulin sensitivity, inflammation (through ketone bodies avoidance pro-inflammatory sugars), pharmacological control (the diet’s mechanisms similar those medication but without side effects), positive impacts psychological factors food addiction. Based authors’ review latest research, reasonable conclude that, due these many additional health benefits, advantageous diet-based This important hypothesis deserves further exploration, which could achieved including outcome measures future clinical trials, especially when comparing different diets equal caloric value.

Language: Английский

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Dietary Influences on Gut Microbiota and Their Role in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 143 - 143

Published: Dec. 31, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major contributor to liver-related morbidity, cardiovascular disease, and metabolic complications. Lifestyle interventions, including diet exercise, are first line in treating MASLD. Dietary approaches such as the low-glycemic-index Mediterranean diet, ketogenic intermittent fasting, high fiber diets have demonstrated potential addressing dysfunction underlying this condition. The development progression of MASLD closely associated with taxonomic shifts gut microbial communities, relationship well-documented literature. Given importance primary treatment for MASLD, it important understand how microbiota their byproducts mediate favorable outcomes induced by healthy dietary patterns. Conversely, changes conferred unhealthy patterns Western may induce dysbiosis influence through promoting hepatic inflammation, up-regulating lipogenesis, dysregulating bile acid metabolism, increasing insulin resistance, causing oxidative damage hepatocytes. Although emerging evidence has identified links between microbiota, significant gaps remain understanding specific roles, metabolite pathways, host interactions, causal relationships. Therefore, review aims provide mechanistic insights into role microbiota-mediated processes analysis both contribution pathophysiology. By better elucidating interplay nutrients, processes, onset work identify new opportunities targeted interventions treat efficiently.

Language: Английский

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Effects of ketogenic and low-carbohydrate diets on the body composition of adults with overweight or obesity: A systematic review and meta-analysis of randomised controlled trials

Clinical Nutrition, Journal Year: 2025, Volume and Issue: 46, P. 10 - 18

Published: Jan. 18, 2025

Language: Английский

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Relationship Between Metabolic Age Determined by Bioimpedance and Insulin Resistance Risk Scales in Spanish Workers

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 945 - 945

Published: March 8, 2025

Introduction: Metabolic age (MA) is the difference between an individual’s actual and of their body based on physiological biological factors. It indicator that reflects a person’s physical state, regardless chronological age. Insulin resistance (IR) health disorder in which tissues exhibit reduced response to circulating glucose uptake stimulated by insulin. Objective: The aim this study evaluate association MA, determined through bioelectrical impedance analysis, risk IR, assessed using validated scales, cohort Spanish workers. Methodology: A descriptive cross-sectional was conducted 8590 workers assess MA set sociodemographic variables, habits, IR scales such as Triglyceride–Glucose Index (TyG Index), Score for Resistance (METS-IR), Single Point Sensitivity Estimator (SPISE). Results: All analyzed variables were associated with values, strongest associations observed scale values (OR 4.88 [95% CI 4.12–5.65] METS-IR, 4.42 3.70–5.15] SPISE, 3.42 2.97–3.87] TyG Index) activity. Conclusions: influenced age, sex, social class; habits smoking, activity, adherence Mediterranean diet; values.

Language: Английский

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Linoleic Acid, Mitochondria, Gut Microbiome, and Metabolic Health: A Mechanistic Review

Advances in Redox Research, Journal Year: 2025, Volume and Issue: unknown, P. 100128 - 100128

Published: April 1, 2025

Language: Английский

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Ketogenic Diet in Steatotic Liver Disease: A Metabolic Approach to Hepatic Health

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1269 - 1269

Published: April 4, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major cause of chronic dysfunction worldwide, characterized by hepatic steatosis that may progress to nonalcoholic steatohepatitis and cirrhosis. Owing its strong association with metabolic disorders, current management focuses on weight reduction via lifestyle modifications. Recently, the very-low-calorie ketogenic diet (VLCKD) has emerged as promising intervention due potential for rapid loss in fat. This review aims evaluate clinical evidence regarding impact diets steatosis. We conducted an extensive MEDLINE literature search databases including PubMed, Scopus, Web Science up December 2024. Studies assessing effects or low-carbohydrate high-fat fat, evaluated imaging, histology, biochemical markers, were included. The analysis indicates significantly reduce fat content improve parameters, insulin sensitivity enzyme levels. Evidence further suggests substituting saturated fats unsaturated replacing carbohydrates proteins enhance these benefits. However, considerable variability exists among studies long-term data remain limited. Although short-term outcomes are encouraging, adverse such dyslipidaemia, gastrointestinal disturbances, transient 'keto flu' symptoms require careful monitoring. Future research should focus elucidating underlying mechanisms, optimizing dietary composition, safety establish robust strategy managing MASLD.

Language: Английский

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Exploring the ketogenic diet’s potential in reducing neuroinflammation and modulating immune responses

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 12, 2024

The ketogenic diet (KD) is marked by a substantial decrease in carbohydrate intake and an elevated consumption of fats proteins, leading to metabolic state referred as “ketosis,” where become the primary source energy. Recent research has underscored potential advantages KD mitigating risk various illnesses, including type 2 diabetes, hyperlipidemia, heart disease, cancer. macronutrient distribution typically entails high lipid intake, moderate protein consumption, low intake. Restricting carbohydrates below 50 g/day induces catabolic state, prompting alterations such gluconeogenesis ketogenesis. Ketogenesis diminishes fat glucose accumulation energy reserves, stimulating production fatty acids. Neurodegenerative diseases, encompassing Alzheimer’s Parkinson’s disease are hallmarked persistent neuroinflammation. Evolving evidence indicates that immune activation neuroinflammation play significant role pathogenesis these diseases. protective effects linked generation ketone bodies (KB), which pivotal this dietary protocol. Considering findings, narrative review seeks delve into modulating response. Grasping immunomodulatory on central nervous system could offer valuable insights innovative therapeutic approaches for incapacitating conditions.

Language: Английский

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