The journal of nutrition health & aging,
Journal Year:
2023,
Volume and Issue:
27(12), P. 1196 - 1205
Published: Nov. 29, 2023
This
study
aimed
to
evaluate
the
association
between
macronutrient
intake
and
bone
mineral
density
(BMD)
using
non-substitution
substitution
statistical
approaches.
Longitudinal
analysis.
1,317
adults
in
Health
Worker
Cohort
Study
Mexico.
These
participants
were
assessed
at
baseline
(2004–2006)
follow-up
(2010–2012).
Dietary
intakes
validated
food
frequency
questionnaires.
BMD
different
sites
was
performed
by
dual-energy
X-ray
absorptiometry
(DXA).
Hybrid-mixed
effects
regression
models
associations
of
interest.
Cross-sectional
found
fiber
higher
total
hip
femoral
neck
women
longitudinal
with
loss
men.
An
increase
5%
energy
from
carbohydrate
associated
a
several
site
In
both
sexes,
an
animal
protein
or
fat
site-specific
gain
after
six
years.
Substitution
analysis
showed
that
replacement
had
women;
while
men,
it
only
significant
when
replacing
carbohydrate.
carbohydrates
lower
women,
Our
findings
suggest
BMD,
among
Mexican
population.
Macronutrient
substitutions
resulted
associations;
however,
additional
studies
are
needed
confirm
these
findings.
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 22, 2023
Abstract
Background
Observational
research
suggested
a
suggestive
relationship
between
frailty
index
(FI)
and
osteoporosis,
falls
fractures.
Aims
This
study
aimed
to
explore
genetic
causality
identified
that
higher
genetically
predicted
FI
positively
correlated
with
increased
risks
of
falls,
Methods
Genome-wide
association
summary
data
were
used
identify
variants
strongly
related
FI.
GWAS
Heel
Bone
mineral
density,
fall
risk
fracture
at
different
site
was
considered
as
outcome.
Inverse
variance-weighted
(IVW)
analysis
mainly
applied;
MR-Egger
the
weighted
median
also
obtain
robust
estimates.
A
series
sensitivity
analyses
detect
pleiotropy
or
heterogeneity.
Then,
we
adjustment
Body
Mass
Index
(BMI)
type
2
diabetes
(T2DM)
using
multivariable
Mendelian
randomization
(MVMR).
Results
In
main
analysis,
Frailty
associated
Osteoporosis
fall.
What’s
more,
significantly
contributed
an
Density
(BMD).
MVMR,
after
correcting
for
diabetes,
causal
BMD
has
turned
into
negative
regulation.
comprehensive
consistent
estimate.
Horizontal
heterogeneity
absent
in
our
MR
study.
Discussion
The
results
provide
evidence
offering
avenues
interventions
alleviates
burden
these
health
concerns.
Conclusions
Our
suggest
potentially
The journal of nutrition health & aging,
Journal Year:
2023,
Volume and Issue:
27(12), P. 1196 - 1205
Published: Nov. 29, 2023
This
study
aimed
to
evaluate
the
association
between
macronutrient
intake
and
bone
mineral
density
(BMD)
using
non-substitution
substitution
statistical
approaches.
Longitudinal
analysis.
1,317
adults
in
Health
Worker
Cohort
Study
Mexico.
These
participants
were
assessed
at
baseline
(2004–2006)
follow-up
(2010–2012).
Dietary
intakes
validated
food
frequency
questionnaires.
BMD
different
sites
was
performed
by
dual-energy
X-ray
absorptiometry
(DXA).
Hybrid-mixed
effects
regression
models
associations
of
interest.
Cross-sectional
found
fiber
higher
total
hip
femoral
neck
women
longitudinal
with
loss
men.
An
increase
5%
energy
from
carbohydrate
associated
a
several
site
In
both
sexes,
an
animal
protein
or
fat
site-specific
gain
after
six
years.
Substitution
analysis
showed
that
replacement
had
women;
while
men,
it
only
significant
when
replacing
carbohydrate.
carbohydrates
lower
women,
Our
findings
suggest
BMD,
among
Mexican
population.
Macronutrient
substitutions
resulted
associations;
however,
additional
studies
are
needed
confirm
these
findings.
