Deleted Journal,
Journal Year:
2023,
Volume and Issue:
13(2)
Published: Dec. 28, 2023
Chemoprevention
strategies,
which
aim
to
prevent
or
reduce
the
risk
of
cancer
using
natural
products,
align
with
Maqasid
Shariah
by
promoting
preservation
life
and
protection
health,
are
fundamental
objectives
Islamic
law.
This
review
aimed
understand
role
products
(plants
source)
as
chemoprevention
from
viewpoint.
The
study
their
conceptualization
in
parallel
Al-Qur’an
As-Sunnah
were
found
through
a
thorough
search
literature.
is
type
intervention
that,
accordance
first
principle
emphasis
on
(hifz
al-nafs).
Several
types
plant
resources
mentioned
Al-Qur'an
Al-Hadith
for
instance,
dates,
figs,
olive,
fennel,
acacia,
cucumber,
pomegranate,
ginger,
onion,
black
cumin
possessed
medicinal
properties
disease
treatments
anti-cancer
effects.
While
different
respond
differently
anticancer
agents,
this
has
identified
categories
plants
chemopreventive
efficacy
concept
that
can
serve
guide
additional
in-depth
research
biomedical
sciences
field.Keywords:
chemoprevention,
perspective,
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(19), P. 4276 - 4276
Published: Oct. 7, 2023
Breast
cancer
(BC)
is
the
most
common
malignancy,
and
conventional
medicine
has
failed
to
establish
efficient
treatment
modalities.
Conventional
due
lack
of
knowledge
mechanisms
that
underpin
onset
metastasis
tumors,
as
well
resistance
regimen.
However,
Complementary
Alternative
(CAM)
modalities
are
currently
drawing
attention
both
public
health
professionals.
Our
study
examined
effect
a
super-combination
(SC)
crude
extracts,
which
were
isolated
from
three
selected
Qatari
medicinal
plants,
on
proliferation,
motility
death
BC
cells.
results
revealed
SC
attenuated
cell
growth
caused
MDA-MB-231
cells
when
compared
human
normal
neonatal
fibroblast
On
other
hand,
functional
assays
showed
reduced
migration
invasion,
respectively.
SC-inhibited
cycle
SC-regulated
apoptosis
was
likely
mediated
by
p53/p21
pathway
p53-regulated
Bax/BCL-2/Caspace-3
pathway.
ongoing
experiments
aim
validate
these
in
vitro
findings
vivo
using
BC-Xenograft
mouse
model.
These
support
our
hypothesis
inhibited
proliferation
induced
apoptosis.
lay
foundation
for
further
experiments,
aiming
an
effective
chemoprevention
and/or
chemotherapeutic
strategy
can
ultimately
pave
way
towards
translational
research/clinical
trials
eradication
BC.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(12), P. 1731 - 1731
Published: Dec. 15, 2023
The
failure
to
treat
infectious
diseases
due
the
continual
emergence
of
drug-resistant
microbes
poses
a
huge
and
serious
challenge
for
human
health
globally.
Currently,
discovery
development
natural
therapeutic
compounds
are
attracting
considerable
attention
from
researchers
worldwide.
In
this
project,
two
types
pollen
grains
(maize
clover)
were
evaluated
potential
antimicrobial
activities.
Extracts
both
purified
using
HPLC,
which
has
been
shown
have
numerous
phenolic
flavonoid
compounds.
Pyro
catechol
methyl
gallate
detected
in
high
concentrations
(1145.56
1056.57
µg/mL,
respectively)
maize
extract,
while
caffeic
acid,
quercetin,
kaempferol
(464.73,
393.05,
390.93
among
observed
at
clover
extract.
Staphylococcus
aureus,
Escherichia
coli,
Salmonella
typhi,
Candida
albicans
more
sensitive
extract
with
inhibition
zones
22
±
0.2,
18
0.1,
29
0.3,
42
0.4
mm
compared
size
inhibitory
caused
by
(19
15
0.4,
27
mm,
respectively).
Moreover,
lower
MIC
values
recorded
against
C.
(1.97
0.04
µg/mL),
S.
aureus
(62.5
1.00
E.
coli
0.07
µg/mL)
than
MICs
use
transmission
electron
microscope
revealed
that
had
treated
showed
changes
its
cell
walls
exhibited
stronger
antioxidant
potential,
an
IC50
value
22.18
54.85
µg/mL
via
DPPH
scavenging
assay.
Regarding
anticancer
activity,
was
be
effective
terms
inhibiting
colon
cancer
line
HCT-116,
67.02
1.37
toxicity
75.03
1.02
µg/mL.
Overall,
demonstrated
potent
antibacterial
activities,
but
not
when
Thus,
current
findings
related
(clover
maize)
highlight
their
applications
treatment
certain
malignancies.
Journal of Pure and Applied Microbiology,
Journal Year:
2024,
Volume and Issue:
18(2), P. 1372 - 1385
Published: June 1, 2024
The
phenolic
compounds
of
four
Palestinian
honey
samples
(PH1-PH4)
and
their
antibacterial
effects
as
well
cytotoxic,
cytostatic,
antimigration
in
human
breast
cancer
cell
line
(MDA)
were
evaluated
here.
HPLC
analysis
PH2
(Cornflower),
PH3
(Milk
thistle),
PH4
(Ziziphus)
revealed
15
compounds,
namely,
caffeic
acid,
carvacrol,
chrysin,
ellagic
galangin,
gallic
kaempferol,
p-coumaric
pinobanksin,
pinocembrin,
protocatechuic
quercetin,
rutin,
salicylic
silydamin.
minimum
inhibitory
concentration
(MIC)
method
applied
to
Pseudomonas
aeruginosa
(P.
aeruginosa),
Staphylococcus
aureus
(S.
aureus),
Escherichia
coli
(E.
coli).
A
strong
positive
correlation
was
detected
between
antimicrobial
activity
coli)
IC50
values
for
DPPH
neutralization
varied
from
0.19
w/w%
10
w/w%.
potential
anticancer
properties
the
on
MDA
cells.
Samples
demonstrated
cytostatic
activity,
reducing
viability
by
about
43%
at
non-toxic
4
mg/mL.
strongly
correlated
with
presence
acid
(p
<
0.01).
Moreover,
migration
rate
significantly
reduced
(by
up
85%)
compared
untreated
cells
0.05).
observed
carvacrol
Pinocembrin
Our
findings
validate
honey’s
suggest
its
benefits
may
stem
effects.
Targets,
Journal Year:
2024,
Volume and Issue:
2(2), P. 64 - 79
Published: April 26, 2024
Honey
has
become
popular
as
a
potential
treatment
for
several
ailments,
including
cancer.
Honeys
from
different
parts
of
the
world
have
been
shown
to
anti-proliferative,
immune-modulatory,
and
anti-inflammatory
actions.
Yemeni
Sidr
honey
(YSH)
is
world-renowned
its
activity
suggested
anti-cancer
activity,
although
empirical
evidence
lacking.
We
tested
three
YSH
samples
by
HPLC
show
they
contained
similar
sugars
an
overlapping
group
phenolic
flavonoid
components,
described
previously.
YSH’s
apoptotic
anti-proliferative
activities
were
measured
in
vitro
models
cancer
growth.
The
breast
cell
lines
(MDA-MB-231
MCF-7),
cervical
line
(HeLa),
mouse
melanoma
cells
(B16-BL6)
with
1%
(w/v)
media
48–72
h
almost
completely
inhibited
proliferation
promoted
apoptosis.
In
contrast,
non-malignant
HBL-100
was
more
resistant
YSH.
This
suggests
that
may
be
good
candidate
treatment,
which
requires
further
study.
Journal of Cancer Prevention & Current Research,
Journal Year:
2024,
Volume and Issue:
15(2), P. 40 - 44
Published: Jan. 1, 2024
Background:
Nowadays,
breast
cancer
is
one
of
the
main
causes
deaths
among
women
worldwide.
It
represents
a
major
challenge
in
healthcare
systems.
With
increasing
rates
mortality
and
adverse
effects
conventional
therapy,
prompt
insight
into
honey-based
therapeutics
was
crucial
for
developing
new
effective
complementary
alternative
medicine.
As
natural
product
with
its
long
history
use
traditional
medicine,
honey
has
drawn
attention
thousands
scientists
over
past
few
years
treating
various
types
cancers,
particularly
cancer.
Its
anticancer
properties
are
mainly
attributed
to
complex
composition
valuable
phyto
compounds.
Methods:
In
this
review,
our
study
sheds
light
on
their
properties,
antioxidant
potency,
prognosis
impact
patients
referring
bibliographical
data
collected
from
2020
2024.
Discussion:
Several
studies
unveiled
outstanding
potential
modulate
apoptosis,
immune
response,
inflammation
processes.
healing
powers
could
also
be
explained
by
potency
preventive
against
oxidative
stress
which
often
cancers.
Similarly,
remarkable
have
been
widely
debated.
Honey
does
not
only
improve
life
quality
undergoing
chemotherapy
reducing
side
but
increases
survival
rates.
Conclusion:
promising
therapy
that
enhance
effectiveness
treatments.
Deleted Journal,
Journal Year:
2023,
Volume and Issue:
13(2)
Published: Dec. 28, 2023
Chemoprevention
strategies,
which
aim
to
prevent
or
reduce
the
risk
of
cancer
using
natural
products,
align
with
Maqasid
Shariah
by
promoting
preservation
life
and
protection
health,
are
fundamental
objectives
Islamic
law.
This
review
aimed
understand
role
products
(plants
source)
as
chemoprevention
from
viewpoint.
The
study
their
conceptualization
in
parallel
Al-Qur’an
As-Sunnah
were
found
through
a
thorough
search
literature.
is
type
intervention
that,
accordance
first
principle
emphasis
on
(hifz
al-nafs).
Several
types
plant
resources
mentioned
Al-Qur'an
Al-Hadith
for
instance,
dates,
figs,
olive,
fennel,
acacia,
cucumber,
pomegranate,
ginger,
onion,
black
cumin
possessed
medicinal
properties
disease
treatments
anti-cancer
effects.
While
different
respond
differently
anticancer
agents,
this
has
identified
categories
plants
chemopreventive
efficacy
concept
that
can
serve
guide
additional
in-depth
research
biomedical
sciences
field.Keywords:
chemoprevention,
perspective,
