Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)
Published: Sept. 14, 2024
Language: Английский
Neuroscience Bulletin, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 4, 2025
Language: Английский
Citations
2
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: April 29, 2024
Obesity, a chronic global health problem, is associated with an increase in various comorbidities, such as cardiovascular disease, type 2 diabetes mellitus, hypertension, and certain types of cancer. The increasing prevalence obesity requires research into new therapeutic strategies. Glucagon-like peptide-1 receptor agonists, specifically semaglutide liraglutide, designed for mellitus treatment, have been explored drugs the treatment obesity. This minireview describes molecular mechanisms liraglutide different metabolic pathways, its mechanism action processes appetite regulation, insulin secretion, glucose homeostasis, energy expenditure, lipid metabolism. Finally, several clinical trial outcomes are described to show safety efficacy these management.
Language: Английский
Citations
13
Neuroscience, Journal Year: 2025, Volume and Issue: 567, P. 235 - 248
Published: Jan. 5, 2025
Language: Английский
Citations
1
Current Nutrition Reports, Journal Year: 2024, Volume and Issue: 13(2), P. 194 - 213
Published: March 25, 2024
Abstract Purpose of Review This review aims to explore in-depth the different aspects association between very low-calorie ketogenic diet (VLCKD), obesity and obesity-related thyroid dysfunction. Recent Findings The VLCKD, proposed as a non-pharmacological strategy for management certain chronic diseases, is becoming increasingly popular worldwide. Initially used treat epilepsy, it has been shown be effective in controlling body weight gain addressing various pathophysiological conditions. Research that low-calorie, high-fat can affect hormone levels. Weight loss also influence Studies have suggested long-term use VLCKD refractory epilepsy may related development hypothyroidism, with an effect seen populations. In particular, women following tend reduced T3 Summary We propose further research unravel underlying mechanisms linking
Language: Английский
Citations
7
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(4), P. 514 - 514
Published: April 8, 2024
Diabetic Parkinson’s disease (DP) is a progressive neurodegenerative with metabolic syndrome that increasing worldwide. Emerging research suggests cannabidiol (CBD) neuropharmacological compound acts against this disease, especially CBD in nano-formulation. The safety of lipid nanoparticles (CBD-LNP) was evaluated by assessing vitro cytotoxicity neurons and therapeutic outcomes DP animal model, including parameters histopathology. CBD-LNPs were fabricated using microfluidization technique showed significantly lower than the natural form CBD. rats induced streptozotocin followed 4-week injection MPTP high-fat diet. Rats treated orally vehicle, CBD, CBD-LNP, or levodopa for 4 weeks daily. As result, vehicle-treated exhibited abnormalities, decreased striatal dopamine levels, motor memory deficits. CBD-LNP demonstrated reduced profiles, enhanced insulin secretion, restored levels compared to form. also had comparable efficacy ameliorating deficits impairment behavior tests. Interestingly, presented migration damaged neuronal cells hippocampus more levodopa. These findings suggest holds promise as an intervention addressing both aspects DP, offering potential strategy.
Language: Английский
Citations
5
Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 2993 - 2993
Published: Nov. 7, 2023
Dopamine regulates several functions, such as voluntary movements, spatial memory, motivation, sleep, arousal, feeding, immune function, maternal behaviors, and lactation. Less clear is the role of dopamine in pathophysiology type 2 diabetes mellitus (T2D) chronic complications conditions frequently associated with it. This review summarizes recent evidence on regulating insular metabolism activity, traditional T2D, pathophysiological interconnection between T2D neurological psychiatric disorders characterized by impaired activity/metabolism, therapeutic implications. Reinforcing signaling especially patients dopamine-related disorders, Parkinson’s Huntington’s diseases, addictions, attention-deficit/hyperactivity disorder. On other hand, although specific trials are probably needed, certain medications approved for (e.g., metformin, pioglitazone, incretin-based therapy, gliflozins) may have a due to anti-inflammatory anti-oxidative effects, improvement insulin signaling, neuroinflammation, mitochondrial dysfunction, autophagy, apoptosis, restoration striatal synthesis, modulation reward hedonic eating. Last, targeting could potential diagnostic purposes diabetes-related complications, diabetic retinopathy.
Language: Английский
Citations
11
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: July 30, 2024
Diabetes mellitus is a growing disease with severe complications. Various scores predict the risk of developing this pathology. The amount muscle mass associated insulin resistance, yet there no established evidence linking diabetes risk. This work aims to study that relationship.
Language: Английский
Citations
4
npj Parkinson s Disease, Journal Year: 2025, Volume and Issue: 11(1)
Published: Jan. 14, 2025
Magnetic resonance imaging and circulating molecular testing are potential methods for diagnosing treating Parkinson's disease (PD). However, their relationships remain insufficiently studied. Using genome-wide association summary statistics, we found in the general population a genetic negative correlation between white matter tract mean diffusivity PD (-0.17 < Rg -0.11, p 0.05), positive with intracellular volume fraction (0.12 0.2, 0.05). Additionally, 1345 genes causally linked were enriched muscle physiological abnormalities (padj Notable genes, including LRRC37A4P (effect size = 15.7, 1.23E-55) KANSL1-AS1 -15.3, 1.13E-52), directly associated PD. Moreover, 23 genetically correlated PD-IDP pairs (PPH4 > 0.8), SH2B1 TRIM10. Our study bridges gap genetics, neuroimaging, pathology, suggests novel targets diagnosis treatment.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 16, 2025
Language: Английский
Citations
0
Journal of Neural Transmission, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 23, 2025
Abstract Parkinson’s disease (PD) is a chronic neurodegenerative of the elderly. Patients suffer from progressive motor and non-motor symptoms. Further, PD patients often present geriatric features like multimorbidity polypharmacotherapy. A frequent comorbidity diabetes mellitus type two (T2DM). In last decade growing evidence emerged on impact T2DM PD. Of review was to analyze incidence progression in patient cohorts. systematic literature performed via PubMed Google Scholar. Studies longitudinal cohorts with at least 10 per group were included. The diabetic state had be determined. total, 15 studies analyzed for this review. According most included increases risk developing significantly. Disease augmented by both cognitive impairments. Some also point out correlation worsening status measured serum HbA1c level. relation biomarkers, have higher neurofilament light chain Tau level but lower Amyloid beta seems factor development should screened treatment initiated promptly. There still lack knowledge about molecular mechanisms leading interactions these diseases.
Language: Английский
Citations
0