The chrononutrition of human milk: role of the circadian variation in human milk composition on sleep-wake regulation and brain development of infant

Current Opinion in Food Science, Journal Year: 2025, Volume and Issue: unknown, P. 101283 - 101283

Published: Feb. 1, 2025

Language: Английский

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Bioactive compounds in human milk

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Purpose of review: Human milk is the optimal food choice for infants. Reviewing latest advances in research about human compounds and their effect on health helps understand benefits breastfeeding improves knowledge key bioactive nutrients that can be used to improve feeding during infancy, with short long-time effects health. Recent findings: In last years, it has been described how such as oligosaccharides, hormones, lipids, cellular components microbes play an important role infants’ health, reducing risk infectious, metabolic autoimmune diseases. The mechanisms transmission from mother infant these are not always well described, but there several lines biological beneficial effects. Summary: These findings may help maternal interventions, modifiable factors able modulate composition. They development formulas enhance nutritional plans. Also, identification isolation describe new ways supplementation.

Language: Английский

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The Effect of Maternal Overweight/Obesity on Serum and Breastmilk Leptin, and Its Associations with Body Composition, Cardiometabolic Health Indices, and Maternal Diet: The BLOOM Study

Metabolites, Journal Year: 2024, Volume and Issue: 14(4), P. 221 - 221

Published: April 13, 2024

In overweight and obese patients, elevated serum breastmilk leptin concentrations are observed, with also being likely affected by the diet. We analyzed in normal weight (NW) overweight/obese (OW/OB) mothers, evaluated its associations (1) maternal anthropometric parameters; (2) markers of cardiometabolic health; (3) The BLOOM (Breastmilk Link to Overweight/Obesity Maternal diet) study was conducted among 40 women (n = 20 OW/OB; n 20, NW) who were exclusively or predominantly breastfeeding for 15.5 ± 1.2 (OW/OB group) weeks. collected 24 h fasting blood samples analysis ELISA. dietary habits using a 3-day record food frequency questionnaire, which used calculate Polish-adapted Mediterranean Diet score. measurements DEXA scans performed, indices calculated. OW mothers had 1.4 times higher levels, while OB 4.5 6.2 respectively, comparison NW mothers. FM% correlated levels (r 0.878, r 0.638). Serum associated health such as AIP, CMI, VAI LAP OW/OB Higher energy, fructose intake adherence diet (β 0.323, 0.039–0.608; β 0.318, 0.065–0.572; 0.279, 0.031–0.528); meanwhile, could protect against −0.444, −0.839–−0.050), even after adjustment FM%. Our results suggest potential association between health. addition, we confirm importance healthy patterns improvement composition.

Language: Английский

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Investigation of Relationships between Intakes of Human Milk Total Lipids and Metabolic Hormones and Infant Sex and Body Composition

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2739 - 2739

Published: Aug. 16, 2024

Human milk (HM) composition, including metabolic hormones and lipids, is influenced by various factors, lactation stage and, potentially, infant sex, which may affect body composition (BC) development. We aimed to: (a) characterize the longitudinal concentration intake profiles of HM leptin, adiponectin, insulin, total lipids; (b) determine if their concentrations intakes differ sex; (c) explore relationships with development BC. Milk samples (

Language: Английский

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The validation of an LC-MS/MS method for the quantification of vitamin D metabolites in human milk and their biological variability in Gambian women

The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2024, Volume and Issue: unknown, P. 106633 - 106633

Published: Nov. 1, 2024

Language: Английский

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Biological clock and circadian rhythm of breast milk composition

Chronobiology International, Journal Year: 2024, Volume and Issue: 41(8), P. 1226 - 1236

Published: July 22, 2024

Breast milk provides numerous benefits for both the baby and mother, making it a unique valuable food. The World Health Organization United Nations International Children's Emergency Found (UNICEF) state that exclusive breastfeeding in first six months of life is an important strategy reducing mortality morbidity infants. circadian rhythm formation, which starts mother's womb, continues after born. plays active role regulating baby's through hormones, basic immune factors bioactive components contains, as well meeting almost all nutritional elements babies. Since neural control mechanisms newborn are not yet fully developed, breast undertakes task helping biological rhythms regulation infant's sleep-wake cycles, thanks to some its composition. There studies showing contains high levels cortisol amino acids promote activity during day, while night has melatonin tryptophan, micronutrients vary throughout day. A better understanding displayed by composition improving maternal infant health. there many affecting milk, recommended should be done on country or regional basis, policies can developed result results obtained.

Language: Английский

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Sampling Procedures for Estimating the Infant Intake of Human Milk Leptin, Adiponectin, Insulin, Glucose, and Total Lipid

Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 331 - 331

Published: Jan. 23, 2024

Limited attention is given to the efficacy of protocols for estimation infant intake milk components when investigating their impact on outcomes. We compared actual measured human with estimations derived from 15 determine most reliable approach estimating HM leptin, adiponectin, insulin, glucose, and total lipid. Twenty mothers who were 3–5 months postpartum completed a 24 h profile study pre-/post-feed samples collection. The true (control group) based (MI) was estimated intakes using concentrations five sampling that multiplied by one MI, considered mean MI (800 mL), or global (766 mL). six (three sets pre- post-feed samples, morning (06:00–09:00), afternoon (13:00–16:00), evening (19:00–22:00)) produced accurate estimates these components. Therefore, in absence measurements sampling, protocol comprising three provides

Language: Английский

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Maternal Reports of Preterm and Sick Term Infants’ Settling, Sleeping and Feeding in the 9 Months after Discharge from Neonatal Nursery: An Observational Study

Children, Journal Year: 2024, Volume and Issue: 11(6), P. 655 - 655

Published: May 28, 2024

The effects of preterm birth, neonatal morbidities and environmental influences on infant sleep development is an important yet under-researched topic, with little known about normative for infants born sick or preterm. aim this prospective, observational longitudinal study was to evaluate maternal perceptions degree bother behaviours feeding outcomes across the first 9 months after discharge sick/preterm cared in intensive care unit (NICU) healthy term-born infants. This paper reports cohort (I = 94) that were recruited from two NICUs Perth, Western Australia. Total scores average 20.2% higher at than weeks post-discharge (p < 0.001). Increased night waking frequency, evening settling duration crying all positively associated total scores. Maternal confidence negatively scores; each increase confidence, decreased by 8.5% Covariates such as birth gestation, breastfeeding status multiple births not bother. Families may benefit additional support when experiencing increased frequency durations NICU.

Language: Английский

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Breastfeeding in the prevention of long-term consequences of neuropsychiatric pathology in offspring with gestational diabetes mellitus

Journal of obstetrics and women s diseases, Journal Year: 2024, Volume and Issue: 73(4), P. 107 - 118

Published: Oct. 7, 2024

This literature review summarizes modern concepts of gestational diabetes mellitus as an independent risk factor for the development long-term neuropsychiatric diseases in offspring and mechanisms their programming this complication pregnancy absence protective role maternal melatonin a consequence chronodestruction. The article presents data on composition breast milk participation its endogenous melatonin, microRNAs, long non-coding RNAs, stem cells, microbiome reprogramming epigenetic disorders result adverse effects antenatal period, which helps to reduce likelihood developing pathology later life. It is emphasized that breastfeeding during first six months life later, along with complementary foods under age two years older, exclusively physiological unsurpassed method preventing consequences impaired brain mellitus.

Language: Английский

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BREAST MILK HORMONES AS RISK FACTORS OR PROTECTORS OF CHILDHOOD OBESITY

CASPIANJOURNALOF MEDICINE AND PHARMACY, Journal Year: 2024, Volume and Issue: unknown, P. 11 - 21

Published: Oct. 15, 2024

The current data on the role of breast milk hormones in development obesity children are summarized. Based analysis domestic and foreign special scientific practical literature databases PubMed, Scopus, Elsevier, eLibrary, information genetic basis is considered. results systematization received, question was raised about need for further research this area due to relevance problems being discussed.

Language: Английский

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