Abstract
The
full
text
of
this
preprint
has
been
withdrawn
by
the
authors
while
they
make
corrections
to
work.
Therefore,
do
not
wish
work
be
cited
as
a
reference.
Questions
should
directed
corresponding
author.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4968 - 4968
Published: May 2, 2024
Breast
cancer
is
one
of
the
most
common
cancers
worldwide,
at
same
time
being
prevalent
causes
women’s
death.
Many
factors
such
as
alcohol,
weight
fluctuations,
or
hormonal
replacement
therapy
can
potentially
contribute
to
breast
development
and
progression.
Another
important
factor
in
onset
includes
micronutrient
status.
In
this
narrative
review,
we
analyzed
23
micronutrients
their
possible
influence
on
Further,
aim
study
was
investigate
impact
status
prevention
its
various
therapeutic
pathways.
We
researched
meta-analyses,
systemic
reviews,
retrospective
studies,
well
original
studies
human
animal
models.
The
results
these
indicate
a
correlation
between
different
levels
decreased
risk
better
survival
rate.
However,
further
are
necessary
establish
adequate
doses
supplementation
chosen
exact
mechanisms
therapy.
Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: April 1, 2025
Background
While
the
role
of
specific
nutrients
in
cancer
is
established,
associations
between
comprehensive
dietary
nutrient
intake
and
presence
remain
underexplored.
This
cross-sectional
study
investigates
global
profiles
relation
to
solid
blood
cancers.
Methods
A
total
42,732
mobile
adults
from
National
Health
Nutrition
Examination
Survey
(NHANES,
2001–2023)
were
enrolled
this
study.
The
potential
intakes
34
4
common
trace
components
with
investigated
by
weighted
logistic
regression
restricted
cubic
spline.
Results
Higher
saturated
fatty
acid
(OR
=
1.1082,
95%
CI:
1.0110–1.2146),
β
-carotene
1.0431,
1.0096–1.0777)
vitamin
K
1.0370,
1.0094–1.0654)
was
positively
associated
overall
presence,
while
phosphorus
0.9016,
0.8218–0.9892)
showed
a
protective
association.
For
tumors,
1.1099),
α
1.0353),
1.0484),
1.0405)
exhibited
positive
associations.
Retinol
linked
carcinoma
1.0935,
1.0222–1.1698).
Dose–response
analyses
revealed
linear
relationships
without
non-linear
thresholds.
Conclusion
Specific
nutrients,
notably
fats,
carotenoids,
K,
are
increased
whereas
reduced
presence.
Due
nature
measurement
after
diagnosis,
causal
relationship
could
not
be
established.
These
findings
underscore
need
for
longitudinal
studies
establish
causality
inform
interventions
management.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(11), P. 2126 - 2126
Published: June 3, 2024
Tumors
that
spontaneously
shrink
from
unknown
causes
in
tumor
regression,
and
return
to
normal
cells
reversion,
are
phenomena
with
the
potential
contribute
new
knowledge
novel
therapies
for
cancer
patient
survival.
Tumorigenesis
is
associated
dysregulated
phosphate
metabolism
an
increased
transport
of
into
cells,
potentially
mediated
by
overload
excessive
dietary
intake,
a
significant
problem
Western
societies.
This
paper
proposes
reduced
reregulated
may
reverse
imbalance
kinases
phosphatases
cell
signaling
cellular
proliferation,
thereby
activating
autophagy
regression
reversion.
Dietary
can
also
be
sickness-associated
anorexia,
fasting-mimicking
diets,
other
diets
low
phosphate,
all
which
have
been
regression.
Tumor
reversion
has
demonstrated
transplanting
healthy
microenvironment,
plausibly
concentrations.
Evidence
suggests
sequestration
containment
within
encapsulated
tumors
protective
patients,
preventing
release
lethal
amounts
general
circulation.
Reducing
provide
novel,
safe,
effective
therapy
further
research
warranted.
Abstract
This
study
aims
to
reveal
the
influence
of
SERPINA1
gene
on
development,
prognosis
evaluation
and
immune
environment
changes
breast
cancer.
Cell
lines
with
different
expression
were
constructed
explore
its
impact
biological
behavior
cancer
cell
lines.
The
in
tumor
tissues
patients
undergoing
surgery
our
hospital
was
detected
by
immunohistochemistry
evaluate
regulatory
effect
microenvironment.
results
found
that
overexpression
could
significantly
inhibit
proliferation
migration
cells
promote
apoptosis.
Transcriptome
sequencing
analysis
revealed
may
regulate
affecting
functional
pathways
such
as
adaptive
response,
natural
killer
cell-mediated
cytotoxicity,
phosphatidylinositol
signaling
system.
Western
blot
showed
accompanied
an
increase
PTEN
a
decrease
Akt
mTOR
phosphorylation
levels,
suggesting
molecular
mechanism
which
cooperate
negatively
passage
PI3K.
In
addition,
high
is
related
recruitment
T
(Treg)
tissues,
change
Frontiers in Molecular Biosciences,
Journal Year:
2024,
Volume and Issue:
11
Published: May 1, 2024
Objective
Breast
cancer
is
highly
heterogeneous,
presenting
challenges
in
prognostic
assessment.
Developing
a
universally
applicable
model
could
simplify
clinical
decision-making.
This
study
aims
to
develop
and
validate
novel
breast
prognosis
using
coagulation-related
genes
with
broad
applicability.
Methods
A
total
of
203
related
coagulation
were
obtained
from
the
KEGG
database,
mRNA
data
1,099
tumor
tissue
samples
572
normal
retrieved
TCGA-BRCA
cohort
GTEx
databases.
The
R
package
“limma”
was
utilized
detect
variations
gene
expression
between
malignancies
tissue.
constructed
TCGA
through
multivariable
Cox
regression
analysis,
followed
by
validation
GSE42568
dataset
as
testing
set.
Constructing
nomogram
incorporating
factors
enhance
predictive
capacity
model.
Utilizing
ESTIMATE
algorithm
investigate
immune
infiltration
levels
groups
deferent
risk.
Performing
drug
sensitivity
analysis
“oncoPredict”
package.
Results
risk
consisting
six
coagulation-associated
(SERPINA1,
SERPINF2,
C1S,
CFB,
RASGRP1,
TLN2)
created
successfully
tested
for
validation.
Identified
6
that
serve
protective
model’s
development.
Kaplan-Meier
curves
revealed
worse
high-risk
group
compared
low-risk
group.
ROC
showed
accurately
forecasted
overall
survival
(OS)
patients
at
1,
3,
5
years.
Nomogram
accompanied
calibration
can
also
provide
better
guidance
more
likely
respond
well
immunotherapy,
whereas
may
show
improved
responses
Gemcitabine
treatment.
Furthermore,
individuals
distinct
categories
displayed
different
various
medications
within
identical
therapeutic
category.
Conclusion
We
established
explored
its
utility.
offers
valuable
insights
decision-making
selection
patients,
contributing
personalized
precise
treatment
advancements.
Medicines,
Journal Year:
2024,
Volume and Issue:
11(2), P. 5 - 5
Published: Jan. 30, 2024
Cancer
therapeutics
have
a
low
success
rate
in
clinical
trials.
An
interdisciplinary
approach
is
needed
to
translate
basic,
clinical,
and
remote
fields
of
research
knowledge
into
novel
cancer
treatments.
Recent
has
identified
high
dietary
phosphate
intake
as
risk
factor
associated
with
incidence.
A
model
tumor
dynamics
predicted
that
reducing
levels
sequestered
the
microenvironment
could
substantially
reduce
size.
Coincidently,
low-phosphate
diet
already
use
help
patients
chronic
kidney
disease
manage
serum
levels.
Electrochem,
Journal Year:
2024,
Volume and Issue:
5(2), P. 178 - 212
Published: May 21, 2024
Food
quality
assessment
is
becoming
a
global
priority
due
to
population
growth
and
the
rise
of
ionic
pollutants
derived
from
anthropogenic
sources.
However,
current
methods
used
quantify
toxic
ions
are
expensive
their
operation
complex.
Consequently,
there
need
for
affordable
accessible
accurate
determination
ion
concentrations
in
food.
Electrochemical
sensors
based
on
potentiometry
represent
promising
approach
this
field,
with
potential
overcome
limitations
currently
available
systems.
This
review
summarizes
advances
electrochemical
quantification
heavy
metals
anions
food
industry
using
potentiometric
sensors.
The
healthcare
impact
common
metal
contaminants
(Cd2+,
Hg2+,
Pb2+,
As3+)
(ClO4−,
F−,
HPO4−,
SO42−,
NO3−,
NO2−)
discussed,
alongside
regulations,
gold
standard
analysis.
Sensor
performances
compared
benchmarks
terms
selectivity
limit
detection.
Given
complexity
samples,
percentage
recovery
values
(%)
methodologies
employed
extraction
also
described.
Finally,
summary
challenges
future
directions
field
provided.
An
overview
technologies
that
can
shown,
including
new
Cancers,
Journal Year:
2023,
Volume and Issue:
15(20), P. 5093 - 5093
Published: Oct. 21, 2023
Breast
cancer
is
associated
with
phosphate
toxicity,
the
toxic
effect
from
dysregulated
metabolism
that
can
stimulate
tumorigenesis.
Phosphate
toxicity
and
are
also
bone
mineral
abnormalities,
including
excessive
loss
deposition.
Based
on
shared
associations
a
hypothesis
proposed
in
present
mixed
methods–grounded
theory
study
posits
middle-aged
women
incidence
of
breast
had
greater
magnitude
changes
density
over
time
compared
who
remained
cancer-free.
To
test
this
hypothesis,
mixed-effects
model
was
used
to
analyze
spinal
U.S.
Study
Women’s
Health
Across
Nation.
Compared
cohort
cancer-free,
self-reported
higher
at
baseline,
but
more
rapid
losses
during
follow-up
visits.
These
findings
agree
women.
The
have
implications
for
studies
investigating
as
causative
factors
metastasis
metastatic
cancer.
Additionally,
authors
previously
found
increased
risk
high
dietary
intake
same
women,
should
investigate
low-phosphorus
diet
reduce
abnormalities
tumorigenesis
patients.
