Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Biomimetics, Journal Year: 2024, Volume and Issue: 9(3), P. 154 - 154

Published: March 1, 2024

The incidence of microbial infections in orthopedic prosthetic surgeries is a perennial problem that increases morbidity and mortality, representing one the major complications such medical interventions. emergence novel technologies, especially 3D printing, represents promising avenue development for reducing risk eventualities. There are already host biomaterials, suitable being tested antimicrobial properties when they coated with bioactive compounds, as antibiotics, or combined hydrogels antioxidant properties, chitosan metal nanoparticles, among others. materials discussed context this paper comprise beta-tricalcium phosphate (β-TCP), biphasic calcium (BCP), hydroxyapatite, lithium disilicate glass, polyetheretherketone (PEEK), poly(propylene fumarate) (PPF), poly(trimethylene carbonate) (PTMC), zirconia. While recent research results promising, further required to address increasing antibiotic resistance exhibited by several common pathogens, potential fungal infections, toxicity some nanoparticles. Other solutions, like incorporation phytochemicals, should also be explored. Incorporating artificial intelligence (AI) certain implants use AI against bacterial might represent viable solutions these problems. Finally, there legal considerations associated biomaterials widespread which must taken into account.

Language: Английский

---

Bioturbation analysis of microbial communities and flavor metabolism in a high-yielding cellulase Bacillus subtilis biofortified Daqu

Food Chemistry X, Journal Year: 2024, Volume and Issue: 22, P. 101382 - 101382

Published: April 16, 2024

In this study, a fortified Daqu (FF Daqu) was prepared using high cellulase-producing

Language: Английский

---

Capsaicin: Emerging Pharmacological and Therapeutic Insights

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(8), P. 7895 - 7943

Published: July 24, 2024

Capsaicin, the most prominent pungent compound of chilli peppers, has been used in traditional medicine systems for centuries; it already a number established clinical and industrial applications. Capsaicin is known to act through TRPV1 receptor, which exists various tissues; capsaicin hepatically metabolised, having half-life correlated with method application. Research on applications different formulations still ongoing. Thus, local have pronounced anti-inflammatory effect, while systemic multitude effects because their increased lipophilic character ensures augmented bioavailability. Furthermore, teams documented capsaicin's anti-cancer effects, proven both vivo vitro designs. A notable constraint therapeutic its toxicity, especially sensitive tissues. Regarding capsaicin, apart from all recorded as medicinal application acupuncture points demonstrated be effective combination warrants further research. Finally, antimicrobial can supplement anti-carcinogenic actions.

Language: Английский

---

Kaempferol: A Review of Current Evidence of Its Antiviral Potential

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(22), P. 16299 - 16299

Published: Nov. 14, 2023

Kaempferol and its derivatives are flavonoids found in various plants, a considerable number of these have been used medical applications worldwide. compounds well-known antioxidant, anti-inflammatory antimicrobial properties among other health benefits. However, the antiviral kaempferol notable, there is significant experimental studies on this topic. were effective against DNA viruses such as hepatitis B virus, alphaherpesvirinae family, African swine fever pseudorabies virus; they also RNA viruses, namely feline SARS coronavirus, dengue Japanese encephalitis influenza enterovirus 71, poliovirus, respiratory syncytial human immunodeficiency calicivirus, chikungunya virus. On hand, no effectiveness murine norovirus A virus could be determined. The action mechanisms various, inhibition viral polymerases attachment entry into host cells. Future research should focused further elucidating from different plants assessing their potential use to complement drugs.

Language: Английский

---

Sweet Bell Pepper: A Focus on Its Nutritional Qualities and Illness-Alleviated Properties

Indian Journal of Clinical Biochemistry, Journal Year: 2023, Volume and Issue: 39(4), P. 459 - 469

Published: Dec. 9, 2023

Language: Английский

---

Unlocking the potential of capsaicin in oral health (Review)

Biomedical Reports, Journal Year: 2024, Volume and Issue: 21(5)

Published: Aug. 22, 2024

Capsaicin is a bioactive compound found prominently in

Language: Английский

---

A comprehensive review on sustainable strategies for valorization of pepper waste and their potential application

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 1, 2025

Abstract Pepper is an economically important crop grown worldwide for consumption as a vegetable and spice. Much waste, including plant seeds, stalks, placenta, peels, other processing byproducts, generated by consumers during pepper production, processing, retail, households. These peppers byproducts contain numerous bioactive compounds that can be used ingredients developing functional foods, nutraceuticals, food industries. This review summarizes the recent developments in valorization of waste. The content different wastes, their extraction processes, biological activities, applications are discussed given special attention. waste rich sources nutrients compounds, such vitamins, dietary fiber, capsaicinoids, phenolics, flavonoids, carotenoids, which possess health‐promoting effects, antioxidant, antimicrobial, anti‐inflammatory, antidiabetic, anti‐obesity, anticancer activities. Considering potential application food, pharmaceutical industries, future studies recommended to develop efficient economical green techniques evaluate sensorial characteristics, bioaccessibility, safety compounds. Several strategies also available technologies valorize possible than biomedical However, sustainability check joint effort stakeholders at all levels key reducing sustainable

Language: Английский

---

The First Use of Monodisperse Poly(Propylene Glycol)-8 as a Polymeric Additive: Enhanced Gelation Temperature and Hydrophobic Drug Release in Pluronic Hydrogels

Published: Jan. 1, 2025

Language: Английский

---

Effects of chili meal supplementation on productive performance, intestinal health, and liver lipid metabolism of laying hens fed low-protein diets

Poultry Science, Journal Year: 2025, Volume and Issue: 104(5), P. 105001 - 105001

Published: March 6, 2025

This study aimed to explore the effects of chili meal (CM), a by-product pepper oil extraction, on productive performance, intestinal health, and lipid metabolism laying hens fed low-protein (LP) diets. A total 384 Hy-Line brown (32 weeks old) were divided into six groups: control (CON) diet with 16.5 % crude protein (CP), LP 15 CP, diets supplemented 3 %, 5 7 9 CM. Results showed that dietary CM supplementation up did not negatively affect performance However, groups receiving exhibited significant increase in feed-to-egg ratio (P < 0.05). Additionally, effectively enhanced egg yolk color dose-dependent manner Intestinal morphology analysis indicated group had higher villus height-to-crypt depth than 0.05), no differences among other groups. Dietary %-7 significantly serum jejunal antioxidant capacity, highest levels malondialdehyde increased anti-inflammatory cytokines (IL-4 IL-10) decreased pro-inflammatory (IL-1β, IL-6, TNF-α) tissue Moreover, altered cecal microbiota composition hens, increasing abundance beneficial bacteria, such as Desulfovibrio Megamonas. Furthermore, triglyceride levels; downregulated liver mRNA ACC, FAS, SREBP-1C/2; upregulated ACOX1, PPAR-α, Apob, CPT In conclusion, should exceed avoid negative impacts while supporting health metabolism.

Language: Английский

---

Phytochemical-based Drugs for Salmonella Biofilm Disruption

Royal Society of Chemistry eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 123 - 143

Published: April 9, 2025

The prevalence and antibiotic resistance of Salmonella biofilms pose significant challenges in infection treatment food safety. Utilizing plant extracts phytochemicals as phyto-drugs offers an alternative strategy to control biofilm formation. Phyto-drugs, including extracts, essential oils, purified phytochemicals, individually or combined, are crucial addressing these challenges. Terpenes, flavonoids, phenols, tannins, alkaloids like quercetin, piperine, berberine show promise for future phyto-drug development against biofilm. Thymol, carvacrol, eugenol, notably from Origanum vulgare, exhibit antibiofilm activity, inducing stress-related proteins Salmonella. Other oil constituents farnesol isomers, malvalic acid, isoshogaol, Z-phytol also promise. Plant-derived act both planktonic forms by disrupting formation, motility, adhesion, QS. Strategies include inhibiting cellulose synthesis QS systems. Phyto-synthesized nanoparticles offer a promising avenue, effectively combating microbial while being cost-effective environmentally friendly. Integrating with synthetic antimicrobial drugs demonstrates potential biofilm-related issues resistance.

Language: Английский

---