The Association Between Chronic Liver Disease and Osteoporosis in East Asian Populations: A Bidirectional Mendelian Randomization Study DOI Creative Commons
Zhiyu Wang,

Qi Qu,

Rui Jiang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Abstract Background Chronic liver disease is a widespread health problem globally, particularly common in East Asia. Osteoporosis (OP), as metabolic bone disease, has also gained increasing attention aging societies. In recent years, studies have suggested possible association between chronic and OP, but their causal relationship not been fully or systematically studied. Objective To investigate the OP Asian populations using Mendelian randomization (MR) methods. Methods The datasets for hepatitis B infection (CHB), C (CHC), cirrhosis were sourced from UK Biobank, while those hepatocellular carcinoma (HCC) Japan Biobank. All participants included populations. We first treated exposure outcome MR analysis, then performed reverse analysis treating outcome. inverse variance-weighted (IVW) method was used primary to calculate odds ratios (ORs) 95% confidence intervals (95% CIs). MR-Egger weighted median supplementary approaches assess OP. Heterogeneity pleiotropy tests ensure reliability of results. Results IVW results indicated that CHB (ebi-a-GCST90018584) will increase incidence (bbj-a-137) (OR = 1.063, CI: 1.015–1.112, p 0.009), with no evidence heterogeneity pleiotropy. However, found CHC, cirrhosis, HCC on Reverse analyses did reveal any significant effect disease. Conclusion populations, Therefore, patients only require long-term antiviral treatment protect should monitor over time reduce risk ultimately improving quality life.

Language: Английский

Recent advances in Artemisia argyi Levl. et Vant. polysaccharides: Extractions, purifications, structural characteristics, pharmacological activities, and existing and potential applications DOI
Wenjing Hu,

Aiqi Yu,

Haizheng Bi

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135250 - 135250

Published: Aug. 31, 2024

Language: Английский

Citations

5
Osteosarcopenia: the coexistence of sarcopenia and osteopenia is predictive of prognosis and postoperative complications after curative resection for colorectal cancer DOI

Takaaki Fujimoto,

Koji Tamura, Kinuko Nagayoshi

et al.

Surgery Today, Journal Year: 2024, Volume and Issue: unknown

Published: June 16, 2024

Language: Английский

Citations

4
Investigating the Effects and Mechanisms of Combined Vitamin D and K Supplementation in Postmenopausal Women: An Up-to-Date Comprehensive Review of Clinical Studies DOI Open Access
Marius Emil Rusu, Galya Bigman, Alice S. Ryan

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2356 - 2356

Published: July 20, 2024

Aging is a complex process and significant risk factor for chronic diseases. Menopause, component of aging in women, associated with several important cardiometabolic conditions including metabolic syndrome, osteoporosis, cardiovascular Menopausal women could benefit from preventative strategies that may decrease morbidity mortality improve their quality life. Vitamins D K are essential nutrients required bone health, immune function, reducing risks, yet synergistic effect less understood women. This the first comprehensive review to summarize evidence found randomized clinical trials beneficial effects vitamin co-treatment postmenopausal In our literature search across key electronic databases such as Cochrane, PubMed, Ovid, we identified 31 pertinent studies. Overall, findings indicate combined intake vitamins positively affect health emphasizing importance maintaining healthy diet rich vegetables fermented dairy products. Given challenges obtaining all necessary solely through diet, supplements recommended promote well-being.

Language: Английский

Citations

4
Association between life’s essential 8 and bone mineral density among adults aged 20–59 years DOI Creative Commons

Yuyu Cui,

Zhening Xu,

Zhaoshu Cui

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 21, 2025

This study investigates the relationship between Life's Essential 8 (LE8) scores and bone mineral density (BMD) in adults aged 20–59 years. cross-sectional analysis employed nationally representative data from NHANES 2011–2018. Weighted multiple linear regression models were applied to assess association LE8 varying levels of cardiovascular health (CVH) with BMD. Subgroup analyses performed evaluate differences impact on BMD across age groups, genders, races, socioeconomic statuses, BMI categories. The included 2159 participants. After adjusting for all covariates, demonstrated a significant positive lumbar spine BMD, thoracic trunk total Individuals medium high CVH groups exhibited higher compared those low group. indicated that was more evident participants 20–35 years among normal BMI. In females, appeared particularly sensitive changes scores. identifies Higher linked greater These findings highlight importance adopting comprehensive strategies, suggesting improving may contribute maintaining supporting skeletal health.

Language: Английский

Citations

0
Association between sarcopenia and cardiovascular disease according to menopausal status: findings from the China Health and Retirement Longitudinal Study (CHARLS) DOI Creative Commons

Xiangdi Dai,

Siqi He,

Yuxiang Wu

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 22, 2025

Little is known about the association between sarcopenia and cardiovascular disease (CVD) according to menopausal status, we conducted cross-sectional as well longitudinal analyses Using nationally representative data from China Health Retirement Longitudinal Study (CHARLS) investigate CVD in Chinese women status. The study sample included 5365 (mean age 60.3 ± 9.3 years) female participants CHARLS 2015 (wave 3). Additionally, 3,882 without were recruited (Wave 3) followed up 2018 4). was defined presence of physician-diagnosed heart and/or stroke. Menopausal status determined based on self-reported information questionnaires. Sarcopenia assessed using diagnostic criteria established by Asian Working Group 2019 (AWGS 2019). Binary logistic regression explore both premenopausal postmenopausal women. Further examined interaction better understand its impact CVD. prevalence total population 22.5% (1209/5365). Among women, no-sarcopenia, possible sarcopenia, group are 11.3% (86/759), 16.2% (17/105), 13.9% (5/36), respectively, for 19.2% (320/1668), 32.6% (520/1597), 21.8% (261/1200). Both (OR = 1.58; 95% CI: 1.29–1.93) 1.34; 1.05,1.72) associated with There a significant positive menopause CVD, RERI 5.30 (95%CI: 4.63, 5.98), SI 2.44 1.84, 3.63), multiplicative effect 2.18 1.70, 2.66). In analysis, 514 (13.2%) new cases diagnosed. significantly development 2.44, 1.3,4.59). 1.45, 1.28, 1.65) 1.42, 1.23, more likely have new-onset than no-sarcopenia risk show variations associations across different statuses, higher risks An found.

Language: Английский

Citations

0
A prospective study to investigate circadian rhythms as health indicator in women’s aging DOI Creative Commons
Deeksha Malhan,

Müge Yalçin,

Stefanie Liedtke

et al.

npj Women s Health, Journal Year: 2025, Volume and Issue: 3(1)

Published: Feb. 28, 2025

Abstract The circadian clock plays a crucial role in regulating the timing of numerous physiological processes. Its dysregulation has severe implications for organism’s homeostasis and is among main characteristics aging. As women age transition through menopause, disruptions rhythms may occur, leading to symptoms such as insomnia, mood changes, or altered energy levels. In this prospective non-randomized cohort study, we seek characterize better understand alterations across various stages their reproductive cycle, both with without daily routine (e.g., specific diet, light exposure). Understanding intricate relationship between female health during aging process essential developing targeted interventions mitigate promote overall well-being menopausal women. Findings from study will be used devise tailored rhythm assessments women, facilitating alleviation menopause-related promoting healthy

Language: Английский

Citations

0
Navigating Nutrition through the Decades: Tailoring Dietary Strategies to Women's Life Stages DOI

Shilpa Sudhakar Harak,

Shila Shelke,

Dhanshri Revannath Mali

et al.

Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 112736 - 112736

Published: March 1, 2025

Language: Английский

Citations

0
Impact of Exercise on Perimenopausal Syndrome: A Systematic Review of Randomized Controlled Trials DOI Open Access

Alistair G.S. Philip,

Har-Amrit Singh,

Shakthi Yogesh Nanjundiah

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Exercise has been contemplated as a natural means to alleviate the symptoms of perimenopause. The need for this study arises from lack data regarding impact exercise on perimenopausal population. primary objective systematic review randomized controlled trials was evaluate in improving various perimenopause, including hot flushes, insomnia, paresthesia, myalgia, arthralgia, palpitations, fatigue, headache, depression, vaginal dryness, and irritability women. An extensive literature conducted according Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) 2020 guidelines, examining relieving syndrome. assessment based readings Blatt-Kupperman Index (KI), scale which 11 perimenopause are rated 0 (absence symptom) 3 (severe). Based studies, there considerable reduction total KI score baseline by 15.7%. Paresthesia reduced 2 points showed greatest improvement. Headache, insomnia decreased an average 1. There no significant improvement psychiatric disorders such depression. Furthermore, its efficacy treating flushes is yet be established, discrepancies exist results. proven effective mild moderate symptoms. However, skepticism remains effectiveness vasomotor symptoms, further scrutiny needed establish it viable therapy.

Language: Английский

Citations

0
MASLD: Prevalence, Mechanisms, and Sex-Based Therapies in Postmenopausal Women DOI Creative Commons
Ilaria Milani,

Marianna Chinucci,

Frida Leonetti

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 855 - 855

Published: April 2, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic influenced by genetic, lifestyle, and environmental factors. While MASLD more prevalent in men, women are at increased risk after menopause, highlighting critical pathogenetic role of sex hormones. The complex interplay between estrogen deficiency, visceral fat accumulation, metabolic syndrome (MetS), inflammation accelerates progression, increases cardiovascular (CV) risk, triggers a cycle worsening adiposity, dysfunction, psychological problems, including eating disorders. Weight loss postmenopausal can significantly improve both outcomes, helping to prevent related conditions. This review examines prevalence MASLD, its comorbidities (type 2 diabetes T2D, CV, mental disorders), mechanisms, pharmacological treatment with GLP-1 receptor agonists (GLP1-RAs), focus on women. Given use GLP1-RAs obesity T2D patients, increase MetS this analyzes potential stable GLP-1–estrogen conjugate as therapeutic approach subgroup. By combining synergistic effects hormones, dual agonist has been shown food intake reward suppression, resulting greater weight improved insulin sensitivity, glucose, lipid metabolism. Therefore, we hypothesize that pharmacotherapy may provide targeted benefits than either hormone alone protecting liver, β-cells, overall health. As these only supported preclinical data, highlights need for future research evaluate confirm mechanisms efficacy clinical settings, particularly

Language: Английский

Citations

0
Cottage cheese, a relatively underexplored cultured dairy product with potential health benefits? DOI Creative Commons
Dominic N. Farsi, Harsh Mathur, Tom Beresford

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: April 6, 2025

Cottage cheese (CC) is a member of the "fresh cheese" family cheeses and widely consumed due to its culinary versatility some perceived health benefits. However, evidence direct effects CC not well established. This review describes production nutritional characteristics CC, before exploring from human intervention, in vitro, vivo models. Despite widespread consumption advocated benefits, there dearth pertaining high-quality randomized controlled trials. To date, limited number intervention models with have explored nutrient bioavailability, metabolic health, appetite regulation, small, niche study populations. Findings vitro suggest that may be an efficacious vehicle for bioactive compounds. In conclusion, cultured dairy product could impose myriad benefits across outcomes including cardiometabolic, gastrointestinal, body composition, status. need trials develop substantiated base relating full potential health.

Language: Английский

Citations

0