Fecal microbiota transplantation in allergic diseases DOI
Ece Tüsüz Önata, Öner Özdemır

World Journal of Methodology, Journal Year: 2024, Volume and Issue: 15(2)

Published: Nov. 27, 2024

Microorganisms such as bacteria, fungi, viruses, parasites living in the human intestine constitute intestinal microbiota. Dysbiosis refers to compositional and quantitative changes that negatively affect healthy gut In recent years, with demonstration many diseases are associated dysbiosis, treatment strategies targeting correction of dysbiosis these have begun be investigated. Faecal microbiota transplantation (FMT) is process transferring faeces from a donor another recipient order restore provide therapeutic benefit. FMT studies gained popularity after probiotic, prebiotic, symbiotic related diseases. has emerged potential new therapy allergic it maintenance immunological balance (T helper 1/T 2 cells) thus suppression responses. this article, definition, application, safety use will discussed current data.

Language: Английский

The microbiome-driven impact of western diet in the development of noncommunicable chronic disorders DOI Creative Commons
Andrea Severino,

Ege Tohumcu,

Luca Tamai

et al.

Best Practice & Research Clinical Gastroenterology, Journal Year: 2024, Volume and Issue: 72, P. 101923 - 101923

Published: May 10, 2024

Noncommunicable chronic disorders (NCDs) are multifactorial that share a state of chronic, low-grade inflammation together with an imbalance gut microbiota. NCDs becoming increasingly prevalent worldwide, and mainly in Western countries, significant impact on global health. Societal changes, the widespread diffusion modern agricultural methods food processing, have led to shift dietary habits over past century, increased diet (WD). WD includes foods high saturated fat, refined sugars, salt, sweeteners, low fiber, is characterized by overeating, frequent snacking, prolonged postprandial state. An increasing body evidence supports association between rising prevalence NCDs. also negatively affects both microbiota immune system driving microbial alterations, barrier dysfunction, intestinal permeability, leakage harmful bacterial metabolites into bloodstream, consequent contribution development systemic inflammation. In this review article we aim dissect role impairment mediating detrimental effects NCDs, identify potential therapeutic strategies.

Language: Английский

Citations

16
Gut microbiome in the first 1000 days and risk for childhood food allergy DOI
Erin C. Davis, Cynthia L. Monaco, Richard A. Insel

et al.

Annals of Allergy Asthma & Immunology, Journal Year: 2024, Volume and Issue: 133(3), P. 252 - 261

Published: March 16, 2024

Language: Английский

Citations

9
Daily egg intake may reduce sensitisation to common allergenic foods among six‐ to nine‐month‐old south African infants: A randomized controlled trial DOI Creative Commons
Regina Nakiranda, Linda Malan, Cristian Ricci

et al.

Pediatric Allergy and Immunology, Journal Year: 2025, Volume and Issue: 36(3)

Published: March 1, 2025

Abstract Background This study aimed to investigate sensitization eggs and other common allergenic foods, allergic symptoms, fatty acid status among infants after introducing daily as a complementary food for 6 months. Methods secondary analysis used data from randomized controlled trial of 500 aged 6–9 months in Jouberton, South Africa, who were randomly assigned receive one egg daily, n = 250 (treatment) or no egg, (control) Clinical allergy symptoms assessed with the Childhood Allergy Immunology Research questionnaire. Infants tested skin prick test at baseline end additional allergens. The composition was analyzed whole blood endpoint. Results At endpoint, 1.9% intervention group 2.0% control (aOR 0.936 [95% CI 0.229, 3.822]; p .926) all foods 7.5% 12.9% 0.515 [0.264, 1.005]; .052). There reported acute egg‐related midpoint two groups. incidence disease during 13.4% 0.545 CI: 0.283, 1.048]; .069). total long‐chain polyunsaturated omega‐6/omega‐3 ratios higher ( β .173 [0.291, 2.898], .021 .198 [0.149, 0.902], .007) effect on omega‐3 composition. Conclusion Complementary feeding may reduce overall foods.

Language: Английский

Citations

1
Role of Nonalcoholic Fatty Liver Disease in Periodontitis: A Bidirectional Relationship DOI Open Access

Hardika S Vegda,

Bhavin Patel, Gaurav Girdhar

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: July 3, 2024

Nonalcoholic fatty liver disease (NAFLD) and periodontitis share common risk factors such as obesity, insulin resistance (IR), dyslipidemia, which contribute to systemic inflammation. It has been suggested that a bidirectional relationship exists between NAFLD periodontitis, indicating one condition may exacerbate the other. is characterized by excessive fat deposition in associated with low-grade chronic There are several for development of NAFLD, including gender, geriatric community, race, ethnicity, poor sleep quality deprivation, physical activity, nutritional status, dysbiosis gut microbiota, increased oxidative stress, overweight, higher body mass index (BMI), IR, type 2 diabetes mellitus (T2DM), metabolic syndrome (MetS), dyslipidemia (hypercholesterolemia), sarcopenia (decreased skeletal muscle mass). This inflammation can progression impairing immune responses exacerbating inflammatory processes periodontal tissues. Furthermore, individuals often exhibit altered lipid metabolism, affect oral microbiota composition, leading susceptibility disease. Conversely, linked through mechanisms involving stress. Chronic release pro-inflammatory cytokines bacterial toxins into bloodstream, contributing hepatic steatosis. Moreover, periodontitis-induced stress promote accumulation further aggravating NAFLD. The interplay underscores importance comprehensive management strategies targeting both conditions. Lifestyle modifications regular exercise, healthy diet, proper hygiene practices crucial preventing managing these interconnected diseases. Additionally, interdisciplinary collaboration hepatologists periodontists essential optimizing patient care improving outcomes periodontitis.

Language: Английский

Citations

5
Longitudinal cytokine and multi-modal health data of an extremely severe ME/CFS patient with HSD reveals insights into immunopathology, and disease severity DOI Creative Commons

Fereshteh Jahanbani,

Justin Sing,

Rajan Douglas Maynard

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 8, 2024

Introduction Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) presents substantial challenges in patient care due to its intricate multisystem nature, comorbidities, and global prevalence. The heterogeneity among populations, coupled with the absence of FDA-approved diagnostics therapeutics, further complicates research into disease etiology managment. Integrating longitudinal multi-omics data clinical, health,textual, pharmaceutical, nutraceutical offers a promising avenue address these complexities, aiding identification underlying causes providing insights effective therapeutics diagnostic strategies. Methods This study focused on an exceptionally severe ME/CFS hypermobility spectrum disorder (HSD) during period marginal symptom improvements. Longitudinal cytokine profiling was conducted alongside collection extensive multi-modal health explore dynamic nature symptoms, severity, triggers, modifying factors. Additionally, updated severity assessment platform two applications, ME-CFSTrackerApp LexiTime, were introduced facilitate real-time tracking enhance patient-physician/researcher communication, evaluate response medical intervention. Results revealed significance Th2-type cytokines highlighted synergistic activities between mast cells eosinophils, skewing Th1 toward Th2 immune responses pathogenesis, particularly cognitive impairment sensorial intolerance. suggests potentially shared mechanism major comorbidities such as HSD, Mast cell activation syndrome, postural orthostatic tachycardia syndrome (POTS), small fiber neuropathy. identified potential roles BCL6 TP53 pathways emphasized importance investigating adverse reactions medication supplements drug interactions progression. Discussion Our advocates for integration artificial intelligence (AI) techniques better understand comorbidities. These findings highlight dysregulated stratification precision medicine our results suggest exploring use low-dose drugs partial agonist activity treatment. comprehensive approach emphasizes adopting patient-centered improve healthcare management, assessment, personalized medicine. Overall, contribute understanding offer avenues future clinical practice.

Language: Английский

Citations

4
Mechanisms underlying changes in intestinal permeability during pregnancy and their implications for maternal and infant health DOI
Guangyu Ma, Zi Chen,

Zhuojun Xie

et al.

Journal of Reproductive Immunology, Journal Year: 2025, Volume and Issue: 168, P. 104423 - 104423

Published: Jan. 8, 2025

Language: Английский

Citations

0
Altered diversity and composition of gut microbiota in Korean children with food allergy DOI Creative Commons
Minyoung Jung, Ji Young Lee, Sukyung Kim

et al.

Clinical and Translational Allergy, Journal Year: 2025, Volume and Issue: 15(3)

Published: March 1, 2025

Language: Английский

Citations

0
Allergenicity of Alternative Proteins: Reduction Mechanisms and Processing Strategies DOI Creative Commons
Deniz Günal‐Köroğlu, Gülşah Karabulut, Gülay Özkan

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

The increasing popularity of alternative proteins has raised concerns about allergenic potential, especially for plant-, insect-, fungal-, and algae-based proteins. Allergies arise when the immune system misidentifies as harmful, triggering IgE-mediated reactions that range from mild to severe. Main factors influencing allergenicity include protein structure, cross-reactivity, processing methods, gut microbiota. Disruptions in health or microbiota balance heighten risks. Common allergens legumes, cereals, nuts, oilseeds, single-cell proteins, insect-based are particularly challenging, they often remain stable resistant heat digestion despite various techniques. Processing such roasting, enzymatic hydrolysis, fermentation, show promise reducing by altering structures breaking down epitopes trigger responses. Future research should focus on optimizing these methods ensure effectively reduce risks while maintaining nutritional quality safety products.

Language: Английский

Citations

0
Is IBS a Food Allergy? Confocal Laser Endomicroscopy Findings in Patients with IBS: A Narrative Review DOI Creative Commons

Federica Pavan,

Andrea Costantino, Gian Eugenio Tontini

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(7), P. 3717 - 3717

Published: March 28, 2025

Irritable bowel syndrome (IBS) is a gut–brain interaction disorder often associated with food-related triggers, yet the efficacy of common exclusion diets remains debated. Confocal laser endomicroscopy (CLE) offers real-time, high-resolution imaging intestinal mucosal changes, allowing visualization food-induced barrier dysfunction. Early evidence indicates that substantial subset IBS patients exhibit acute reactions to specific foods, identified as fluorescein leakage and cell shedding on CLE, over 70% showing symptom improvements after tailored diets. These findings suggest localized immune responses defects may contribute symptoms beyond IgE-driven immunologic mechanisms. However, most CLE-based studies are small, unblinded, heterogeneous, limiting definitive conclusions. Further research needed validate diagnostic accuracy refine protocols, clarify how best integrate CLE into personalized dietary management for difficult-to-treat IBS.

Language: Английский

Citations

0
Impact of the Maternal Microbiome on Neonatal Immune Development DOI Creative Commons
Eleni Dubé‐Zinatelli,

Edwige Mayotte,

Luna Cappelletti

et al.

Journal of Reproductive Immunology, Journal Year: 2025, Volume and Issue: 170, P. 104542 - 104542

Published: May 16, 2025

Language: Английский

Citations

0