Impact of adherence to the Mediterranean diet on stroke risk

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Stroke is a leading cause of morbidity and mortality worldwide, dietary patterns have emerged as significant modifiable factor in stroke prevention. The Mediterranean diet, characterized by high intake fruits, vegetables, whole grains, nuts, olive oil, fish, has been widely recognized for its cardiovascular benefits. However, specific impact on risk requires further elucidation. We conducted comprehensive meta-analysis 30 studies, including both cohort case–control designs, to evaluate the relationship between adherence diet stroke. A systematic search was performed across multiple databases, random-effects model used estimate pooled hazard ratios (HRs) with 95% confidence intervals (CIs). Heterogeneity assessed using I 2 statistic, publication bias examined through funnel plots Egger’s regression test. Additionally, trial sequential analysis determine adequacy sample size. revealed reduction among individuals adhering HR 0.88 (95% CI: 0.84–0.91). Notably, heterogeneity detected ( = 34%). Z-score plot from confirmed that sizes were sufficient draw definitive conclusions. potential identified. studies highly effect (HR 0.54, 0.4–0.73). settings hinted at presence bias, supported Our findings provide robust evidence supporting protective against Despite some cumulative suggests promoting could serve an effective public health strategy Further research recommended explore underlying mechanisms assess diet’s diverse populations.

Language: Английский

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The Role of Food Security in Mediterranean Diet Adherence Among Adolescents: Findings from the EHDLA Study

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 414 - 414

Published: Jan. 27, 2025

Food insecurity is a growing public health concern, particularly among vulnerable groups such as adolescents, and it has been linked to poor nutritional outcomes increased risk of chronic diseases. The Mediterranean diet (MedDiet) recognized for its numerous benefits, yet few studies have explored the association between food adherence MedDiet especially in regions. Objective: This study aimed investigate sample adolescents from Spain. Methods: Data were acquired 2021–2022 school years aged 12–17 enrolled different secondary schools Valle de Ricote, Region Murcia, security was assessed via Spanish Child Security Survey Module (CFSSM-S), Diet Quality Index Children Adolescents (KIDMED). A total 836 participants involved, statistical analyses conducted linear regression models adjusted lifestyle, anthropometric, sociodemographic covariates. Results: After adjusting potential confounders, mean KIDMED score 7.0 (95% confidence interval [CI] 6.7 7.2) food-security group, 6.8 CI 6.3 7.3) low-security 5.9 4.9 6.9) very-low-security group. Notable differences observed with their counterparts very low (p = 0.040). Compared those (57.2%, 95% 51.5% 62.8%), significantly greater likelihood having nonoptimal identified (61.6%, 50.4% 71.8%) (77.4%, 54.5% 90.7%). We significant difference only peers 0.036). Conclusions: findings suggest that negatively impacts adolescents. food-secure peers, showed poorer quality. These results highlight importance addressing through low-cost, high-nutrition programs at improving healthy eating habits, children living low-food-security households.

Language: Английский

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Roles of vitamins and nutrition in obstructive sleep apnea

Expert Review of Respiratory Medicine, Journal Year: 2025, Volume and Issue: 19(2), P. 145 - 163

Published: Feb. 1, 2025

Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder, with a prevalence that rises alongside increasing of obesity. OSA characterized by low-inflammatory state and followed cardiovascular metabolic sequelae. Continuous positive airway pressure (CPAP) represents cornerstone treatment for severe OSA. However, poor compliance CPAP renders challenging venture. Weight loss exercise are recommended as adjunctive options Several diets have proven to facilitate weight loss, alleviate inflammatory status in patients Moreover, several vitamins exhibit antioxidant properties beneficially affect pathology reduce risk complications. This narrative review aims summarize current knowledge regarding effect nutrition vitamin deficiencies on Included were publications, relevant topic, different types design (i.e. cross-sectional studies, cohort clinical trials, systematic reviews, meta-analyses, etc.) indexed PubMed database until 31 March 2024. In addition other food components, such proteins, carbohydrates, anti-inflammatory agents, A, B, C, D, E, sodium, may play beneficial role incidence severity

Language: Английский

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Adherence to the Mediterranean diet and its protective effects against colorectal cancer: a meta-analysis of 26 studies with 2,217,404 participants

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Abstract Colorectal cancer (CRC) is a major global health concern and represents significant public challenge in Hungary, where it exhibits some of the highest morbidity mortality rates European Union. The Mediterranean diet has been suggested to reduce incidence CRC, but comprehensive evidence from diverse study designs needed substantiate this effect. A systematic literature search was conducted PubMed, ClinicalTrials.gov, CENTRAL, Web Science identify randomized controlled trials human clinical 2008 2024 relevant studies. Statistical analysis performed using https://metaanalysisonline.com web application random effects model estimate pooled hazard (HRs). Forest plots, funnel Z -score plots were utilized visualize results. We identified 15 9 case–control studies, encompassing total 2,217,404 subjects. indicated that adherence significantly reduced prevalence CRC (HR = 0.84, 95% CI 0.78–0.91, p < 0.01). This protective effect consistent across sexes, with HRs 0.85 (95% 0.75–0.97, 0.01) for males 0.88 0.79–0.99, 0.03) females. Case–control studies specifically showed substantial 0.51, 0.38–0.68, Notable heterogeneity observed yet priori information size substantially below cumulative sample size, ensuring sufficient data reliable conclusions. findings meta-analysis reinforce role against CRC. results will inform dietary interventions designed mitigate risk, which are within framework Semmelweis Study, an ongoing cohort at University, explore multifaceted causes unhealthy aging Hungary. These aim practical patterns reducing among Hungarian population.

Language: Английский

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The Triad of Sleep, Immunity, and Cancer: A Mediating Perspective

Cells, Journal Year: 2024, Volume and Issue: 13(15), P. 1246 - 1246

Published: July 24, 2024

The triadic interplay between sleep, immunity, and cancer represents a growing area of biomedical research with significant clinical implications. This review synthesizes the current knowledge on how sleep influences immune function, system’s role in dynamics, direct connections patterns risk. After comprehensive overview interrelationships among these three domains, mechanisms function are described, detailing regulates system, effects duration quality responses, underlying molecular cellular mechanisms. Also, complex relationship immunity is explored, highlighting prevention progression, surveillance, tumor microenvironment, implications immunodeficiency modulation then presenting epidemiological evidence linking to risk, biological that influence development, disorders prognosis. mediating highlighted, proposing hypothesized pathways, summarizing from experimental studies, evaluating impact interventions outcomes. concludes by discussing future directions, emphasizing potential for sleep-based treatment, integration management oncology immunotherapy, outlining agenda. agenda includes understanding sleep–immunity–cancer interplay, conducting studies assessing treatment protocols, exploring microenvironment interactions, considering policy public health Through detailed examination interconnected this underscores critical importance modulating outcomes, advocating interdisciplinary strategies harness improved

Language: Английский

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Youth Healthy Eating Index (YHEI) and Diet Adequacy in Relation to Country-Specific National Dietary Recommendations in Children and Adolescents in Five Mediterranean Countries from the DELICIOUS Project

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3907 - 3907

Published: Nov. 15, 2024

The diet quality of younger individuals is decreasing globally, with alarming trends also in the Mediterranean region. aim this study was to assess and adequacy relation country-specific dietary recommendations for children adolescents living area.

Language: Английский

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The Interplay between Sleep Quality, Hedonic Hunger, and Adherence to the Mediterranean Diet among Early Adolescents

Appetite, Journal Year: 2025, Volume and Issue: 206, P. 107845 - 107845

Published: Jan. 2, 2025

Language: Английский

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Associations between social networks, messaging apps, addictive behaviors, and sleep problems in adolescents: the EHDLA study

Frontiers in Behavioral Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Jan. 24, 2025

Objective The current study aims to provide a comprehensive analysis of the relationships between social network (SN) use, messaging apps and addictive behaviors related SNs, sleep-related problems in sample Spanish adolescents. Methods This was cross-sectional using data from Eating Healthy Daily Life Activities (EHDLA) project, which involved adolescents aged 12–17 years three secondary schools Valle de Ricote (Region Murcia, Spain). A 632 studied. use SN (i.e., Facebook, Twitter, Instagram, Snapchat or TikTok) applications WhatsApp) assessed via scale including one item for each SN, were asked what type they used usage profile SN. Short Social Networks Addiction Scale-6 Symptoms (SNAddS-6S) determine behaviors. Generalized linear regression analyses with negative binomial distribution performed associations problems. These adjusted age, sex, body mass index, socioeconomic level, physical activity, sedentary behavior, adherence Mediterranean diet. Results Higher greater presence [prevalence ratio (PR) = 1.04; 95% confidence interval (CI) 1.01–1.07; p 0.015]. Additionally, higher score on toward was, more identified (PR 1.15; Cl 1.09 1.21; &lt; 0.001). Specifically, only Twitter significantly associated 1.10; 1.01 0.035). In terms mood modification, relapse, withdrawal, conflict (mood modification: PR 1.58; CI 1.36 1.84; 0.001; relapse: 1.24; 1.07 1.43; 0.004; withdrawal: 1.28; 1.08 1.51; conflict: 1.19; 1.39; 0.037). Conclusion Our results suggest relationship behaviors, should be confirmed longitudinal intervention studies.

Language: Английский

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The effect of mediterranean diet and chrononutrition on sleep quality: a scoping review

Nutrition Journal, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 26, 2025

The relationship between diet and sleep quality is intricate, with growing evidence suggesting that dietary patterns meal timing (chrononutrition) can significantly influence outcomes. This scoping review aims to compare the impact of Mediterranean chrononutrition methods on variables, including quality, duration, efficiency. While renowned for its health benefits in chronic diseases, focuses how food intake affects circadian biology. Literature search following PRISMA guidelines using PubMed Google Scholar focused effects quality. Studies assessed subjective like Pittsburgh Sleep Quality Index, analyzing data study type, sample size, age group, diet, parameters, Thirty three studies met inclusion criteria, 24 focusing 9 chrononutrition. Among studies, most which were observational 17 reported a positive association adherence improved self-reported while remaining found no significant association. In contrast, supporting was limited, only two out nine having improvement demonstrates more consistent compared However, limitation reviewed mainly cross-sectional or observational, interventional trials. Larger clinical trials are needed determine optimal strategies promoting healthy sleep.

Language: Английский

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Sleep Disorders: Pathogenesis and Therapeutic Interventions

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: March 1, 2025

Sleep disorder significantly disrupts the quality of life for patients. Although it is clinically acknowledged, fundamental neuropathological mechanisms are still not understood. Recent preclinical research has been directed toward understanding underlying sleep deprivation and sleep/wake dysregulation. linked to changes in structure function neural basis cognition. We reviewed circuits related disorders, along with alterations connectivity brain region functions, based on advancements electrophysiology optogenetic/chemogenetic techniques. subsequently outline cellular molecular modifications disorders studies, primarily involving neuronal metabolism, electrophysiological activity, synaptic plasticity, glial cells. Correspondingly, crosstalk between peripheral organs, we elucidate involvement celiac disease hepatic pathogenesis disorders. In this review, mainly discussed at molecular, cellular, circuit levels that contribute disorder. The review also covered potential strategies treating future avenues.

Language: Английский

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