Royal Jelly: Biological Action and Health Benefits

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6023 - 6023

Published: May 30, 2024

Royal jelly (RJ) is a highly nutritious natural product with great potential for use in medicine, cosmetics, and as health-promoting food. This bee mixture of important compounds, such proteins, vitamins, lipids, minerals, hormones, neurotransmitters, flavonoids, polyphenols, that underlie the remarkable biological therapeutic activities RJ. Various bioactive molecules like 10-hydroxy-2-decenoic acid (10-HDA), antibacterial protein, apisin, major royal specific peptides apisimin, royalisin, royalactin, apidaecin, defensin-1, jelleins are characteristic ingredients RJ shows numerous physiological pharmacological properties, including vasodilatory, hypotensive, antihypercholesterolaemic, antidiabetic, immunomodulatory, anti-inflammatory, antioxidant, anti-aging, neuroprotective, antimicrobial, estrogenic, anti-allergic, anti-osteoporotic, anti-tumor effects. Moreover, may reduce menopause symptoms improve health reproductive system, liver, kidneys, promote wound healing. article provides an overview molecular mechanisms underlying beneficial effects various diseases, aging, aging-related complications, special emphasis on components their properties. The data presented should be incentive future clinical studies hopefully will advance our knowledge about facilitate development novel RJ-based opportunities improving human well-being.

Language: Английский

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Drying Kinetics and Thermodynamic Analysis; Enhancing Quinoa (Chenopodium Quinoa Willd.) Quality Profile Via Pre-Treatments Assisted Germination and Processing

Published: Jan. 1, 2025

Language: Английский

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Drying kinetics and thermodynamic analysis; enhancing quinoa (Chenopodium quinoa Willd.) quality profile via pre-treatments assisted germination and processing

Ultrasonics Sonochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 107337 - 107337

Published: April 1, 2025

Pre-treatments assisted germination is an efficient technique to enhance the nutritional profile of Quinoa (Chenopodium quinoa Willd.). The present study investigated impact pre-treatments nutritional, anti-nutritional, and structural properties. grains JQ-778 were subjected various including soaking, ultrasound at 28 kHz &40 (US kHz, US 40 kHz) for 30 min followed by over 96-hour 25 °C in a Biochemical-Incubator, 12/12 h dark light dried temperatures 50 °C, 60 70 combined (70 °C). Among evaluated models, page logarithmic showed best fit, presenting highest, R2 ≥ 0.9991, X2 ≤ 0.0013, RMSE 0.0022, RSS 0.0201. Moisture diffusion varied from 3.74 × 10-9 8.36 10-9, with 0.9272 0.9837, energy activation 18.25 28.41 kJ/mol 0.9533-0.9896. significantly lowered drying time without affecting germinated bioactive components or other qualitative factors. Ultrasonic pre-treatment yielded highest antioxidant potency composite index 98.78 %. contentof phytic acid tannin dropped 66.66 82.99 % 31.48 41.60 %, respectively (p < 0.05). Each treatment altered quinoa's quality attributes. Principal Component Analysis revealed significant correlations between analyses, explaining 80.37 variability. intensity functional groups decreased infrared spectra, although transmission signals was greater pretreated samples than control. Scanning electron microscopy analysis extensive fragmentation surface erosion after treatment. Our data suggests that ultrasound-treated may their value, making them suggested source high-protein grains, components, distinct

Language: Английский

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Current status of research on the role of natural products and their active ingredients in the treatment of cardiovascular aging: a narrative review

Aging advances., Journal Year: 2025, Volume and Issue: 2(2), P. 67 - 74

Published: April 8, 2025

Aging is a multifaceted physiological process marked by alterations in human appearance and the progressive decline organ function. With intensification of global population aging, health older individuals has emerged as critical concern, particularly given significant impact cardiovascular aging on overall outcomes. Although an inevitable natural process, strategies aimed at delaying its progression can enhance In recent years, products have garnered increasing attention for their potential disease intervention, attributed to high efficacy relatively low side-effect profiles. These demonstrated anti-aging effects several studies. This review provides comprehensive overview mechanisms underlying reviews biological activities various active constituents combating aging. It encompasses latest findings trends from both vitro vivo studies, thereby offering theoretical foundation development novel, side effect, rapidly acting drugs that target Natural exert anti-cardiovascular through multiple mechanisms, including antioxidant activity, apoptosis inhibition, anti-thrombosis, anti-fibrosis, anti-atherosclerosis, blood pressure regulation. For instance, water-soluble components Salvia miltiorrhiza , such tanshinone salvianolic acid B, improve function modulating oxidative stress inflammatory responses. Ligustrazine Rhizoma Chuanxiong reduces myocardial injury activating phosphatidylinositol 3-kinase-protein kinase B signaling pathway, whereas Ginkgo biloba leaf extract enhances vascular regulating inflammation. Additionally, animal-derived products, antler peptides royal jelly, cardioprotective effects. However, current studies possess limitations, with insufficient evidence supporting clinical application many products. Their long-term safety humans require further validation. Despite these challenges, hold improving among elderly. continued research into action advancement trials, they are expected become important tools enhancing quality life Future should explore develop safer more effective drugs, contributing positively societal health.

Language: Английский

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Advancing Nutritional Science: Contemporary Perspectives on Diet’s Role in Metabolic Health and Disease Prevention

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1414 - 1414

Published: April 23, 2025

This Special Issue of Diet and Nutrition: Metabolic Diseases showcases cutting-edge research exploring the intersection between nutrition, dietary patterns, public health [...]

Language: Английский

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Mechanistic exploration of royal jelly production in caged honey bees (Apis mellifera)

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 5, 2024

This study investigates the impact of bee pollen nutrition on royal jelly production honey bees (Apis mellifera). Results demonstrate that diet significantly impacts hypopharyngeal gland (HPG) development and expression genes associated with biosynthesis. Bees fed Brassica napus exhibited superior HPG development, increased mrjp1 (encoding a key protein). While cyp450 6AS8 gene enzyme in 10-HDA biosynthesis) was by consumption, no distinct patterns were observed among different types tested. An vitro cage platform for has been established to further understand mechanisms behind bees. The experiment demonstrated positive correlation between number worker total yield per cage. However, when is low, amount each individual needs produce increases. In conclusion, these findings enhance our understanding role production. Furthermore, results from this suggest critical factor production, may possess controllable mechanism regulating secretion.

Language: Английский

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