Gut-Brain Axis to Investigate the Effects of Gut Health on Cognitive Functioning in Adults DOI Open Access
Muddsar Hameed, Fatima Noor,

Hamza Hussain

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: July 10, 2024

Introduction: The gut-brain axis is a bidirectional communication network linking the gastrointestinal tract and central nervous system via neuronal, hormonal, antibody signaling pathways. Central to this connection gut health, encompassing balance functionality of microbiota, which significantly impacts on mental cognitive health. This study investigates association between health functioning in adults, highlighting mechanisms by microbiota influence brain Objective: To examine effects adult performance, with focus processes Methods: A quantitative cross-sectional was conducted Islamabad from January 2024 April 2024, involving 140 participants. Data were collected using comprehensive 16-item questionnaire cognition self-assessment rating scale (C-SARS). psychometric properties these scales assessed, data analyzed Statistical Product Service Solutions (SPSS, v26; IBM SPSS Statistics for Windows, Armonk, NY). Analytical descriptive statistics, including regression, chi-square, independent sample t-tests, mean standard deviation, applied. Results: found moderate associations particularly memory processing speed (R² = 0.17, β -1.9, p 0.12 general cognition; R² 0.01, -0.98, 0.02 memory; 0.03, -0.18, 0.03 speed). Gender marital status differences significant, males exhibiting better scores than females (M 34.1, SD 3.2 vs. M 31.2, 3.2, 0.00), singles showing performance compared married individuals 9.4, 5.4 6.5, 3.7, 0.03). Conclusion: highlights significant functions, suggesting that composition can performance. underscore need consider individual research. Future studies should replicate findings larger samples explore microbiota-targeted interventions enhancement.

Language: Английский

Beyond the Hayflick limit: How microbes influence cellular aging DOI
Mohammad Abavisani,

Saba Faraji,

Negar Ebadpour

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: 104, P. 102657 - 102657

Published: Jan. 7, 2025

Language: Английский

Citations

2
Taming neuroinflammation in Alzheimer's disease: The protective role of phytochemicals through the gut−brain axis DOI Open Access

Yoonsu Kim,

Jinkyu Lim, Jisun Oh

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117277 - 117277

Published: Aug. 9, 2024

Language: Английский

Citations

14
Gut–Brain Axis and Brain Microbiome Interactions from a Medical Perspective DOI Creative Commons
Borros Arneth

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 167 - 167

Published: Feb. 8, 2025

Background: The gut microbiome directly impacts brain health and activity, meaning the two are closely associated. This relationship suggests a link between microbial imbalances diseases such as Alzheimer’s, although multiple other contributing factors, genetics, also play part. Additionally, recent studies discovered that cerebrospinal fluid has some deoxyribonucleic acid (DNA), which can be interpreted to mean exists in too. vagus nerve central nervous immune systems responsible for connection microbiome. Aims Objectives: main aim of this systematic review is analyze existing research on gut–brain axis fill current knowledge gap. Materials Methods: A search was conducted PubMed database based set predefined MeSH terms. Results: After search, 2716 articles meeting parameters were found PubMed. list then downloaded analyzed according inclusion/exclusion criteria, 63 relevant papers selected. Discussion: Bacteria produce substances considered neuroactive. These compounds or indirectly affect function through axis. However, various gaps mechanisms involved need addressed first.

Language: Английский

Citations

1
The Potential Role of Microbiota in Age-Related Cognitive Decline: A Narrative Review of the Underlying Molecular Mechanisms DOI Open Access
Piotr Olejnik, Aleksandra Golenia, Jolanta Małyszko

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1590 - 1590

Published: Feb. 13, 2025

As the world's population continues to age, social patterns are changing, making aging a notable public health challenge. With as major risk factor for cognitive decline, global prevalence of dementia is projected triple in next 25 years. In light growing body evidence involvement microbiota and pathology, its role age-related decline should be explored. Therefore, aim this narrative review thoroughly analyze ways which might affect process decline. Overall, complex phenomenon manifested at systemic, cellular molecular levels. According recent studies, gut composition may influence changes through gut-brain axis. One mechanism involves dysbiosis-related chronic systemic inflammation, leading blood-brain barrier disruption subsequent neuroinflammatory processes. addition inflammaging, induce oxidative stress, another key brain aging. Finally, not only microbiota, but also colonizing oral cavity associated with neurodegenerative diseases.

Language: Английский

Citations

0
Pathological and Inflammatory Consequences of Aging DOI Creative Commons
Mario García‐Domínguez

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 404 - 404

Published: March 12, 2025

Aging is a complex, progressive, and irreversible biological process that entails numerous structural functional changes in the organism. These affect all bodily systems, reducing their ability to respond adapt environment. Chronic inflammation one of key factors driving development age-related diseases, ultimately causing substantial decline abilities older individuals. This persistent inflammatory state (commonly known as “inflammaging”) characterized by elevated levels pro-inflammatory cytokines, an increase oxidative stress, perturbation immune homeostasis. Several factors, including cellular senescence, contribute this milieu, thereby amplifying conditions such cardiovascular disease, neurodegeneration, metabolic disorders. Exploring mechanisms chronic aging essential for developing targeted interventions aimed at promoting healthy aging. review explains strong connection between inflammation, highlighting potential therapeutic approaches like pharmacological treatments, dietary strategies, lifestyle changes.

Language: Английский

Citations

0
Increasing spatial working memory in mice with Akkermansia muciniphila DOI Creative Commons
Ji‐Seon Ahn, Sura Kim,

Eui-Jeong Han

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: April 2, 2025

Language: Английский

Citations

0
Comparative Analysis of Oral, Placental, and Gut Microbiota Characteristics, Functional Features and Microbial Networks in Healthy Pregnant Women DOI
Guangyu Ma, Ping Yang,

Tong Lu

et al.

Journal of Reproductive Immunology, Journal Year: 2025, Volume and Issue: 169, P. 104535 - 104535

Published: April 28, 2025

Language: Английский

Citations

0
The impact of cognitive functions, psychological disorders, and coping strategies on quality of life and disease outcomes in patients with inflammatory bowel diseases: A cross-sectional study DOI Creative Commons
Abeer F. Almarzouki,

Waad Alluhaibi,

Basma Salman

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(30), P. e38982 - e38982

Published: July 26, 2024

Quality of life (QoL) in patients with inflammatory bowel disease (IBD) is influenced by several factors, many which may also impact cognitive function. However, the extent interaction among these QoL, and outcomes IBD remains unknown. We thus aim to characterize relationships psychological disorders, coping mechanisms, function, overall on QoL IBD. This cross-sectional observational study was conducted at an academic care center. evaluated using Short Inflammatory Bowel Disease Questionnaire (SIBDQ), severity Harvey-Bradshaw Index (HBI) for Crohn's (CD) Simple Clinical Colitis Activity (SCCAI) ulcerative colitis (UC). used Hospital Anxiety Depression scale (HADS). Regression models were test associations number hospitalizations, severity, functioning (working memory [WM] reaction time), strategies while controlling anxiety depressive symptoms, age, sex. included 41 (24 CD 17 UC) whose mean age 28.2 (±8.4) years (23 males) SIBDQ score 51.5 (±10.0). Patients more WM errors had lower scores (P = .041), whereas higher levels active UC .008 P .016, respectively). The use avoidant mechanisms associated a significantly hospitalizations .038), who adopted emotion-focused longer illness duration .021). Finally, education found than others. These results confirm cognitive, psychological, factors IBD; however, interrelate remain unclear. Therapies aimed improving both functions conditions be effective patients, play positive role promoting adoption patients.

Language: Английский

Citations

2
The gut-brain-metabolic axis: exploring the role of microbiota in insulin resistance and cognitive function DOI Creative Commons

Gulshara Abildinova,

Valeriy Benberin, Tamara Vochshenkova

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 26, 2024

The gut-brain-metabolic axis has emerged as a critical area of research, highlighting the intricate connections between gut microbiome, metabolic processes, and cognitive function. This review article delves into complex interplay these interconnected systems, exploring their role in development insulin resistance decline. emphasizes pivotal influence microbiota on central nervous system (CNS) function, demonstrating how microbial colonization can program hypothalamic-pituitary-adrenal (HPA) for stress response mice. It further elucidates mechanisms by which carbohydrate metabolism contributes to resistance, key factor pathogenesis disorders impairment. Notably, highlights therapeutic potential targeting through various interventions, such dietary modifications, probiotics, prebiotics, fecal transplantation (FMT). These approaches have shown promising results improving sensitivity function both animal models human studies. also need research elucidate specific species metabolites involved modulating gut-brain axis, well long-term effects safety interventions. Advances metagenomics, metabolomics, bioinformatics are expected provide deeper insights interactions within impact host health. Overall, this comprehensive underscores significance treatment disorders, offering avenue novel strategies system.

Language: Английский

Citations

2
Gut-Brain Axis to Investigate the Effects of Gut Health on Cognitive Functioning in Adults DOI Open Access
Muddsar Hameed, Fatima Noor,

Hamza Hussain

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: July 10, 2024

Introduction: The gut-brain axis is a bidirectional communication network linking the gastrointestinal tract and central nervous system via neuronal, hormonal, antibody signaling pathways. Central to this connection gut health, encompassing balance functionality of microbiota, which significantly impacts on mental cognitive health. This study investigates association between health functioning in adults, highlighting mechanisms by microbiota influence brain Objective: To examine effects adult performance, with focus processes Methods: A quantitative cross-sectional was conducted Islamabad from January 2024 April 2024, involving 140 participants. Data were collected using comprehensive 16-item questionnaire cognition self-assessment rating scale (C-SARS). psychometric properties these scales assessed, data analyzed Statistical Product Service Solutions (SPSS, v26; IBM SPSS Statistics for Windows, Armonk, NY). Analytical descriptive statistics, including regression, chi-square, independent sample t-tests, mean standard deviation, applied. Results: found moderate associations particularly memory processing speed (R² = 0.17, β -1.9, p 0.12 general cognition; R² 0.01, -0.98, 0.02 memory; 0.03, -0.18, 0.03 speed). Gender marital status differences significant, males exhibiting better scores than females (M 34.1, SD 3.2 vs. M 31.2, 3.2, 0.00), singles showing performance compared married individuals 9.4, 5.4 6.5, 3.7, 0.03). Conclusion: highlights significant functions, suggesting that composition can performance. underscore need consider individual research. Future studies should replicate findings larger samples explore microbiota-targeted interventions enhancement.

Language: Английский

Citations

0