Diet and the gut microbiota-immune axis in the context of perinatal mental health: Protocol for a prospective cohort study DOI Creative Commons
Caroline Wallace, Marie‐Claude Audet

Women s Health, Journal Year: 2024, Volume and Issue: 20

Published: Jan. 1, 2024

Background: Physiological and psychosocial changes experienced by women during the perinatal period may put them at risk for postpartum mental health disturbances. Accumulating evidence suggests that dietary patterns influence through modulation of gut microbiota its effects on host immune activity. Thus, targeting via intake could serve as both a preventative therapeutic strategy in improving health. Objectives: Here, we present protocol prospective cohort study primarily aims to determine if diet quality pregnancy is protective against depression severity. Secondary objectives will examine microbiota- blood-based inflammatory markers be associated with relationship between prenatal severity, well associations additional outcomes. Methods Analysis: Dietary symptoms documented 100 pregnant 4 time points postpartum. Participants also provide stool blood samples same composition predicted function factors, respectively. Stool analyzed using 16S ribosomal RNA gene sequencing bioinformatics tools (QIIME 2/PICRUSt2). Inflammatory factors determined high-sensitivity antibody-based immunoassays. Statistical analyses include linear mixed models hierarchical effect models. Ethics: The was approved Research Ethics Boards Royal Ottawa Health Care Group (#2022002) University (#H-06-22-8013). Informed consent obtained from all participants before their enrollment. Discussion: Findings this help develop evidence-based recommendations potential interventions susceptible or suffering issues are accessible, noninvasive, have play role prevention treatment.

Language: Английский

Effects of the Energy-Adjusted Dietary Inflammation Index During Pregnancy on Prenatal Depression: The Mediating Effect of Sleep Quality DOI Open Access

Yuehan Yuan,

Jing-Jing Xu, Qian Lin

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1197 - 1197

Published: March 29, 2025

(1) Background: Prenatal depression is prevalent and can adversely affect maternal infant health. This study aimed to analyze the relationship between energy-adjusted dietary inflammatory index (E-DII) prenatal depression, as well explore mediating effect of sleep quality. (2) Methods: In this cross-sectional study, a total 749 pregnant women were enrolled. The E-DII scores evaluated using semi-quantitative Food Frequency Questionnaires (FFQ); Edinburgh Postpartum Depression Scale (EPDS) was used measure levels; Pittsburgh Sleep Quality Index (PSQI) evaluate quality women. Binary logistic regression analysis employed relationships with quality, depression. bootstrap approach investigate (3) Results: Findings indicated that higher score significantly associated an increased risk compared lowest score, association still existed after adjusting for addition, also lower poor played partial role in proportion mediation relative 34.30%. (4) Conclusions: partially mediated Close monitoring proactive improvement among following pro-inflammatory diet may help reduce developing

Language: Английский

Citations

0
Validation of a Food Frequency Questionnaire: VioScreen-Allergy DOI Open Access
Kaci Pickett‐Nairne, Deborah H. Glueck, Jessica L. Thomson

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3772 - 3772

Published: Nov. 2, 2024

Background/Objectives: An adapted version of an online pictorial food frequency questionnaire (FFQ), VioScreen-Allergy, assesses total dietary intake and allergens foods in the maternal diet index (MDI), linked to offspring allergy. This study assessed intermethod reliability, test–retest external validity VioScreen-Allergy. Methods: Females childbearing age were recruited at Denver Health Children’s Hospital, Colorado, USA, asked complete four 24 h recalls two VioScreen-Allergy FFQs over course a month. All those with least both assessments analyzed. Energy-adjusted non-adjusted linear mixed models (1) compared MDI scores nutrients as measures reliability; (2) evaluated reliability differences between repeated measurements; (3) by modeling associations VioScreen-Allergy-derived beta-carotene orange vegetables Veggie Meter®-assessed skin carotenoids. Bonferroni corrections controlled multiple comparisons within assessment. Results: Of 53 participants enrolled, 25 demographically dissimilar included analysis. There no significant recall mean intakes macronutrients, micronutrients, allergens, or MDI, except for Vitamin C, niacin, cashew allergen protein. measurements either energy-adjusted unadjusted. Both vegetable servings significantly associated Meter®. Conclusions: Although non-significance could have been due low power, clinical well statistical suggest that has reasonable utility trials assessing context overall intake. The VioScreen can also be used future studies assess macro- micronutrient Additional validation different portion sizes eaten infants young children are currently undergoing.

Language: Английский

Citations

1
Plasma Short-Chain Fatty Acids and Hypertensive Disorders of Pregnancy: Results from a Nested Case-Control Study and Two-sample Mendelian Randomization Analysis DOI Creative Commons
Dandan Wang, Lei Wu,

Pei Feng

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 15, 2024

Abstract Background The temporal relationship between Short-chain fatty acids (SCFAs) and hypertensive disorders of pregnancy (HDP) is unclear. This study aimed to examine the probable causal them. Methods A nested case-control including 387 pairs cases with HDP healthy controls was conducted. Seven SCFAs levels in plasma samples drawn at 16-20 gestational weeks before were assayed by GC/MS. individual joint associations examined logistic regression weighted quantile sum (WQS) regression, respectively, followed two-sample bidirectional Mendelian randomization (MR) analysis test underlying causality. Results univariate model found each interquartile increase valerate associated a 32.1% (OR=0.679, 95%CI=0.546-0.844) reduction risk HDP, 29.4%(OR=0.706, 95%CI=0.548-0.910) hypertension (GH) 39.1% (OR=0.609, 95%CI=0.397-0.935) preeclampsia/chronic superimposed preeclampsia (PE/CH-PE). However, after adjustment for covariates, only (OR=0.699, 95% CI=0.516-0.946). In addition, isobutyrate hexanoate lower risks PE/CH-PE. Furthermore, co-exposure could reduce GH. MR showed that acetate (OR=0.784, 95%CI=0.64-0.962), (OR=0.575, 95%CI=0.363-0.909) isovalerate (OR=0.642, 95%CI=0.428-0.963) had protective effects on Meanwhile, PE (OR=0.746, 95%CI=0.6-0.927). Conclusions suggested it necessary appropriately during HDP.

Language: Английский

Citations

0
Diet and the gut microbiota-immune axis in the context of perinatal mental health: Protocol for a prospective cohort study DOI Creative Commons
Caroline Wallace, Marie‐Claude Audet

Women s Health, Journal Year: 2024, Volume and Issue: 20

Published: Jan. 1, 2024

Background: Physiological and psychosocial changes experienced by women during the perinatal period may put them at risk for postpartum mental health disturbances. Accumulating evidence suggests that dietary patterns influence through modulation of gut microbiota its effects on host immune activity. Thus, targeting via intake could serve as both a preventative therapeutic strategy in improving health. Objectives: Here, we present protocol prospective cohort study primarily aims to determine if diet quality pregnancy is protective against depression severity. Secondary objectives will examine microbiota- blood-based inflammatory markers be associated with relationship between prenatal severity, well associations additional outcomes. Methods Analysis: Dietary symptoms documented 100 pregnant 4 time points postpartum. Participants also provide stool blood samples same composition predicted function factors, respectively. Stool analyzed using 16S ribosomal RNA gene sequencing bioinformatics tools (QIIME 2/PICRUSt2). Inflammatory factors determined high-sensitivity antibody-based immunoassays. Statistical analyses include linear mixed models hierarchical effect models. Ethics: The was approved Research Ethics Boards Royal Ottawa Health Care Group (#2022002) University (#H-06-22-8013). Informed consent obtained from all participants before their enrollment. Discussion: Findings this help develop evidence-based recommendations potential interventions susceptible or suffering issues are accessible, noninvasive, have play role prevention treatment.

Language: Английский

Citations

0