Eficácia terapêutica de probióticos presentes na composição do kefir em ensaios clínicos recentes

Caderno Pedagógico, Journal Year: 2025, Volume and Issue: 22(4), P. e14216 - e14216

Published: Feb. 18, 2025

O kefir é um consórcio de microrganismos, principalmente probióticos, com diversas propriedades terapêuticas. Este estudo integrativo analisou ensaios clínicos randomizados publicados em 2024, focando na eficácia dos probióticos presentes no kefir. A pesquisa foi realizada nas bases PubMed (MEDELINE), SciELO, ScienceDirect e Scopus. Os resultados indicaram que o kefir, devido à sua diversidade pode proporcionar benefícios significativos saúde. Entre os principais achados, destacam-se a redução triglicerídeos pacientes obesos, diminuição da gordura corporal, níveis colesterol total, melhora inflamação. Além disso, observada promoção do aumento biodiversidade microbiota intestinal, ajudar das infecções gastrointestinais respiratórias. Também houve nos escores depressão síndrome intestino irritável. Esses achados reforçam potencial terapêutico destacam necessidade mais pesquisas para consolidar expandir conhecimento sobre suas aplicações clínicas

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Efficacy of probiotic supplementation in preventing necrotizing enterocolitis in preterm infants: a systematic review and meta-analysis

The Journal of Maternal-Fetal & Neonatal Medicine, Journal Year: 2025, Volume and Issue: 38(1)

Published: April 9, 2025

Necrotizing enterocolitis (NEC) is a severe condition in preterm infants, involving intestinal inflammation and bacterial invasion, leading to high morbidity mortality. Probiotics may reduce NEC by promoting beneficial gut bacteria, but the role of Bifidobacterium bifidum G001 (BBG001) not well understood. This meta-analysis evaluates effectiveness BBG001 versus placebo preventing NEC, late-onset sepsis, all-cause mortality infants. Following Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines, we conducted systematic review randomized controlled trials (RCTs) from 2014 2024. Databases searched included PubMed, Cochrane Central Register, MEDLINE, EMBASE. Inclusion criteria encompassed RCTs infants (<37 weeks gestation and/or <2500 g birth weight) receiving enteral probiotics, including BBG001, compared placebo. Outcomes assessed were incidence (≥stage II), Data extraction quality assessment independently performed. From 430 identified records, nine studies 7180 met inclusion criteria. significantly reduced risk stage >2 (OR = 0.66; 95% CI [0.47, 0.94], p .02), 0.74; [0.62, 0.89], .001), sepsis 0.71; [0.53, 0.93], .01). It also lowered odds periventricular leukomalacia 0.61; 0.78], < .0001) intraventricular hemorrhage 0.48; [0.33, 0.69], .0001). Additionally, showed protective effect against infection-related outcomes, reducing death attributed infection 0.80; CI: 0.65, 0.99; .04). Probiotic supplementation with appears effective incidence, bloodstream infections, deaths Despite promising results, variability study designs necessitates further large-scale confirm these findings establish BBG001's neonatal care.

Language: Английский

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role of sn-2 palmitate on the development of the infant gut microbiome: A metagenomic insight

Food Research International, Journal Year: 2025, Volume and Issue: unknown, P. 116488 - 116488

Published: April 1, 2025

Language: Английский

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Effect of protein modification in synbiotic infant formula on probiotic metabolic activity and bacterial composition in an infant gut-model

Microbiome Research Reports, Journal Year: 2024, Volume and Issue: 3(3)

Published: June 28, 2024

Microbial colonization of the neonatal gut is pivotal in priming infant's immune system. Human milk (HM) best nutrition for infants and supports development microbiota due to prebiotic compounds probiotic microorganisms. When exclusive breastfeeding not possible, infant formula (IF) with probiotics a strategy support microbiome development. However, knowledge about effects different IF on individual strains limited, as strain-level detection complex ecosystem challenging. The aim present study was show protein forms metabolic activity two isolated from HM ecosystem.

Language: Английский

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Impact of Breast Milk Microbiota on the Neonatal Intestinal Microbiota according to Delivery type and Circumstance, a cross-sectional study

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 26, 2024

Background: A mother's microbiota, including that in her gut, vagina, and breast milk, plays a big role baby's health. Imbalances this microbiota can lead to problems during pregnancy. Several things affect how gets passed down newborn. Objective:investigating the factors affecting passage of from mother baby, see milk bacteria breastfeeding influence types newborn's gut. Methods: This is cross sectional study aimed assess impact on neonatal intestinal Microbiota. The was carried out total 40 mother-infant pairs. 8 had normal vaginal delivery 32 caesarean section delivery. All participants met our collection criteria. Ethical considerations, history taking, examination were done. Mother's samples collected sterile units preserved at minus 18 celsius (oC) freezer. Neonatal stool using protocol containers. Stool not analyzed immediately stored 80 oC specimens mothers subjected Deoxyribonucleic acid (DNA) extraction real time polymerase chain reaction (PCR) microbiota. Results conclusion: most participated neonates males. Most obese, good hygiene, lived urban places. Cesarean frequent (80.0%) mode Bifido abundant type found both neonates’ followed by Strept. Staph. Neonates with positive significantly higher gestational age. A significant association between presence feeding found. antibiotics administration, either infants or their mothers, negatively associated bacteria. Our results indicated age, weight, sex showed no any three milk.

Language: Английский

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Exploring the Potential Probiotic Properties of Bifidobacterium breve DSM 32583—A Novel Strain Isolated from Human Milk

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Human milk is the best nutrition for infants, providing optimal support developing immune system and gut microbiota. Hence, it has been used as source probiotic strain isolation, including members of genus Bifidobacterium, in an effort to provide beneficial effects infants who cannot be exclusively breastfed. However, not all supplemented bifidobacteria can effectively colonise infant gut, nor confer health benefits individual host; therefore, new isolates are needed develop a range dietary products this specific age group. Here, we investigated potential Bifidobacterium breve DSM 32583 isolated from human milk. We show that vitro B. exhibited several characteristics considered fundamental bacteria, survival conditions simulating those present digestive tract, adherence epithelial cell lines, inhibition growth potentially pathogenic microorganisms. Its antibiotic resistance patterns were comparable known bifidobacterial strains, its genome did contain plasmids virulence-associated genes. These results suggest candidate.

Language: Английский

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Bifidobacterium breve DSM 32583 and Limosilactobacillus fermentum CECT5716 postbiotics attenuate S. aureus and IL-33-induced Th2 responses

Microbiological Research, Journal Year: 2024, Volume and Issue: 289, P. 127913 - 127913

Published: Sept. 21, 2024

Language: Английский

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