Advancements in Lactiplantibacillus plantarum : probiotic characteristics, gene editing technologies and applications

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: Jan. 2, 2025

The exploration of microorganisms in fermented products has become a pivotal area scientific research, primarily due to their widespread availability and profound potential improve human health. Among these, Lactiplantibacillus plantarum (formerly known as Lactobacillus plantarum) stands out versatile lactic acid bacterium, prevalent across diverse ecological niches. Its appeal extends beyond its well-documented probiotic benefits include the remarkable plasticity genome, which captivated both industrial stakeholders. Despite this interest, substantial challenges persist fully understanding harnessing L. plantarum. This review aims illuminate attributes plantarum, consolidate current advancements gene editing technologies, explore multifaceted applications wild-type genetically engineered strains.

Language: Английский

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Effect of dietary anthocyanins on the risk factors related to metabolic syndrome: A systematic review and meta-analysis

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0315504 - e0315504

Published: Feb. 10, 2025

This meta-analysis aims to systematically investigate whether dietary anthocyanin supplementation can reduce metabolic syndrome (MetS)-related risk factors: abdominal obesity, dyslipidemia (low high-density lipoprotein cholesterol (HDL-C) and hypertriglyceridemia), hypertension, hyperglycemia by conducting a of randomized controlled trials (RCTs). A systematic search 5 electronic databases (PubMed, Web Science, Scopus, Cochrane Library, Embase) was conducted from inception until April 25, 2024. total 1213 studies were identified, which involving subjects with MetS-related factors, comparing placebo, reporting results on anthropometric, physiological, markers relevant this study selected. Depending the heterogeneity included studies, fixed-effect model applied for low (I2 < 50%), whereas random-effects employed when substantial present ≥ 50%). The weighted mean difference (WMD) 95% confidence intervals (CI) calculated. 29 2006 participants. showed that anthocyanins significantly improved various lipid glycemic markers: HDL-C: increased 0.05 mmol/L (95% CI: 0.01 0.10, p = 0.026), LDL-C: decreased 0.18 -0.28 -0.08, 0.000), Triglycerides (TGs): reduced 0.11 -0.20 -0.02, 0.021), Total (TC): lowered 0.34 -0.49 -0.18, Fasting blood glucose (FBG): 0.29 -0.46 -0.12, 0.001), Glycated hemoglobin (HbA1c): 0.43% -0.74 -0.13, 0.005). Weight: (WMD: -0.12 kg, -0.45 0.21, 0.473), Body mass index (BMI): kg/m2, -0.26 0.03, 0.12), Overall WC: cm, -0.51 0.87, 0.613), Systolic pressure (SBP): mmHg, -1.06 0.82, 0.801), Diastolic (DBP): 0.61 -0.03 1.25, 0.061), Insulin levels: -0.02 mU/L, -0.44 0.40, 0.932), HOMA-IR: -0.11, 0.28, 0.573). Additionally, 100 mg/day dosage reduced: Waist circumference (WC): 0.55 cm -1.09 -0.01, 0.047). Subgroup analyses based intervention duration, dosage, health status, formulation, frequency, physical activity levels, baseline levels corresponding revealed varying significances, particularly in relation pressure. Dietary effectively improve HDL cholesterol, hypertriglyceridemia, hyperglycemia, making them promising adjunct managing MetS. However, it is important note interventions may raise systolic (SBP) diastolic (DBP) depending dose, participant formulation. Clinicians should fully consider these effects recommending supplementation. Further long-term, well-designed, large-scale clinical are needed draw definitive conclusions.

Language: Английский

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Eficácia terapêutica de probióticos presentes na composição do kefir em ensaios clínicos recentes

Caderno Pedagógico, Journal Year: 2025, Volume and Issue: 22(4), P. e14216 - e14216

Published: Feb. 18, 2025

O kefir é um consórcio de microrganismos, principalmente probióticos, com diversas propriedades terapêuticas. Este estudo integrativo analisou ensaios clínicos randomizados publicados em 2024, focando na eficácia dos probióticos presentes no kefir. A pesquisa foi realizada nas bases PubMed (MEDELINE), SciELO, ScienceDirect e Scopus. Os resultados indicaram que o kefir, devido à sua diversidade pode proporcionar benefícios significativos saúde. Entre os principais achados, destacam-se a redução triglicerídeos pacientes obesos, diminuição da gordura corporal, níveis colesterol total, melhora inflamação. Além disso, observada promoção do aumento biodiversidade microbiota intestinal, ajudar das infecções gastrointestinais respiratórias. Também houve nos escores depressão síndrome intestino irritável. Esses achados reforçam potencial terapêutico destacam necessidade mais pesquisas para consolidar expandir conhecimento sobre suas aplicações clínicas

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Effects of Lactiplantibacillus plantarum CBT LP3 and Bifidobacterium breve CBT BR3 supplementation on weight loss and gut microbiota of overweight dogs

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 26, 2024

The prevalence of obesity in dogs is increasing worldwide. This study evaluated the effects a mixed probiotic formula on weight, body condition score (BCS), blood metabolite profiles, and gut microbiota overweight obese over 12-week supplementation period to determine anti-obesity Lactiplantibacillus plantarum CBT LP3 Bifidobacterium breve BR3. was community-based, randomized that sampled 41 with veterinarian-determined BCS 6 or more. physical activity all subjects measured using pedometer designed exclusively for dogs. food intake developed application. Only treatment group received twice daily (3 g per dose). A significant decrease weight (p < 0.0001), serum TG TC = 0.0400), leptin 0.0252), significantly increased adiponectin levels 0.0007) were observed compared values control group. Microbiota analysis showed Erysipelatoclostridium, Staphylococcus, Gemella decreased more than These results suggested BR3 may be effective alleviating

Language: Английский

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Clinical Evaluation of Hovenia dulcis Extract Combinations for Effective Hangover Relief in Humans

Foods, Journal Year: 2024, Volume and Issue: 13(24), P. 4021 - 4021

Published: Dec. 12, 2024

Alcohol consumption is associated with both short- and long-term adverse effects, including hangover symptoms. The objective of this study was to examine the potential benefits traditional beverages containing a combination Hovenia dulcis extract (HD) either Pueraria lobata (HDPB) or glutathione yeast (HDGB) in abbreviating alcohol intoxication mitigating A total 25 participants between ages 19 40 who had previously experienced were evaluated randomized, double-blind, crossover, placebo (PLA)-controlled clinical trial. Results showed that lower blood concentrations HDPB HDGB groups significantly than PLA group at 0.25 0.5 h, suggesting HD aids early metabolism (0 p < 0.05). Analysis hourly Acute Hangover Scale (AHS) all treatment reduced gastrointestinal disorder symptoms compared (p It can be confirmed improved by consuming drinks, apart from effect reducing acetaldehyde concentrations. Therefore, it predicted natural phytochemicals added safe for humans may help accelerate recovery

Language: Английский

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Probiotics in reducing obesity by reconfiguring the gut microbiota.

PubMed, Journal Year: 2024, Volume and Issue: 49(7), P. 1042 - 1051

Published: July 28, 2024

Obesity, as a global health crisis, is increasingly linked to intestinal microecology. Probiotics colonise the body, effectively regulating balance of flora, while strengthening barrier, activating immune response, releasing beneficial substances, and maintaining micro-ecological balance. This process not only enhances defence against pathogens, but also reduces production inflammatory factors lowers level chronic inflammation. However, specific mechanism by which probiotics influence microecology through improve metabolic disorders caused obesity, participate in weight management are clear. Through multiple neural pathways including 'gut-brain axis' their direct interaction with intestine, increase number bacteria intestine inhibit growth harmful bacteria, thus restructuring flora. can optimise environment enhance efficiency food digestion nutrient absorption. show positive effects on obesity reducing fat accumulation, providing individuals new way control body prevent obesity. Therefore, application great significance promoting gut management.

Language: Английский

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