Protective Effects and Mechanisms of Extracts of Gleditsia Sinensis Lam. Thorn on DSS-Induced Colitis in Mice DOI
Xiaoming Liu, Yujie Chen, Yong Liu

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 340, P. 119244 - 119244

Published: Dec. 23, 2024

Language: Английский

Protective role of short-chain fatty acids on intestinal oxidative stress induced by TNF-α DOI Creative Commons
Miguel D. Ferrer, Berta Buey, Laura Grasa

et al.

Cell Stress and Chaperones, Journal Year: 2024, Volume and Issue: 29(6), P. 769 - 776

Published: Nov. 14, 2024

Inflammatory bowel diseases (IBDs) are driven by an exaggerated inflammatory response, which leads to a marked increase in oxidative stress. This, turn, exacerbates the process and causes significant cellular tissue damage. Intestinal dysbiosis, common observation IBD patients, alters production of bacterial metabolites, including short-chain fatty acids (SCFAs), key by-products dietary fiber fermentation. While role SCFAs intestinal physiology is still being elucidated, this study aimed investigate their effects on stress, particularly under conditions induced proinflammatory mediator tumor necrosis factor alpha (TNF-α). The Caco-2/TC7 cell line was employed as vitro model epithelium, cells were treated with range SCFAs, acetate, propionate, butyrate. levels protein lipid oxidation quantified, well activity antioxidant enzymes. Our findings demonstrate that microbiota-derived can effectively mitigate TNF-α-induced stress modulating enzyme activity. TNF-α induces peroxidation inhibiting catalase glutathione peroxidase activities. able upregulate restore levels. These results underscore critical gut microbiota maintaining homeostasis highlight therapeutic potential managing stress-related pathologies.

Language: Английский

Citations

6
Effects of traditional Chinese medicine polysaccharides on chronic diseases by modulating gut microbiota: A review DOI
Xinyu Li, Rixiang Zhu, Qian Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136691 - 136691

Published: Oct. 1, 2024

Language: Английский

Citations

4
Integrated lipid metabolomics and network pharmacology to investigate the potential mechanism of Coix seed in alleviating ulcerative colitis DOI
Zixuan Chen,

Miaomiao Tong,

Jialiang Sun

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 127, P. 106744 - 106744

Published: March 28, 2025

Language: Английский

Citations

0
Huaier polysaccharides inhibits hepatocellular carcinoma via gut microbiota mediated M2 macrophage polarization DOI
Xiaoxuan Li, Hongyun Zhang, Yufei Deng

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139357 - 139357

Published: Dec. 1, 2024

Language: Английский

Citations

3
Huaier inhibits the proliferation and migration of gastrointestinal stromal tumors by regulating the JAK2 / STAT3 signaling pathway DOI

Lianlian Cao,

Zhaoping Li,

Yibo Huang

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119389 - 119389

Published: Jan. 1, 2025

Language: Английский

Citations

0
Huaier relieves oxaliplatin-induced hepatotoxicity through activation of the PI3K/AKT/Nrf2 signaling pathway in C57BL/6 mice DOI Creative Commons
Xinwei Cheng, Zhu Chen, Yunzhou Chen

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e37010 - e37010

Published: Aug. 29, 2024

Highlights•Huaier can be an effective drug to reduce oxaliplatin-induced hepatotoxicity.•ROS-mediated oxidative stress is involved in hepatotoxicity.•Huaier relieves liver stress.•Inhibition of PI3K pathway reverses the hepatoprotective effect Huaier.AbstractHepatotoxicity caused by anticancer medication oxaliplatin (OXA) significantly restricts its clinical use and raises risk damage. Huaier, a fungus found China, has been demonstrated have various beneficial effects adjuvant therapy for cancer. However, preventive impact Huaier against OXA-induced hepatotoxicity still unknown. The potential molecular pathways behind activity were investigated current study Mice intraperitoneally injected with 10 mg/kg OXA once week six consecutive weeks establish injury model. (2 g/kg, 4 8 g/kg) was administered weekly mice gavage weeks. Commercial kits used determine contents glutathione, catalase, superoxide dismutase, malondialdehyde. Quantitative real-time polymerase chain reaction (qRT-PCR) Western blotting assess on expression pathway. exhibited good protective dose-dependent manner, which connected suppression stress, according results biochemical index detection histological staining analysis. In addition, could counteract PI3K/AKT signaling Moreover, activation eradicated LY294002. These findings imply that decreasing minimize injury, establishing groundwork lessen chemotherapy-induced practice.

Language: Английский

Citations

1
Edible fungi polysaccharides modulate gut microbiota and lipid metabolism: A review DOI

Huanyi Xu,

Zhixiang Xue, Ping Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137427 - 137427

Published: Nov. 12, 2024

Language: Английский

Citations

1
Soybean bioactive peptide supplementation improves gut health and metabolism in broiler chickens DOI Creative Commons

Han Peng,

Xiaoyan Song,

Jialei Chen

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 104(2), P. 104727 - 104727

Published: Dec. 22, 2024

This study aimed to investigate the effects of soybean bioactive peptide (SBP) on growth performance and intestinal health yellow-feathered broilers further elucidate regulatory mechanisms using multi-omics analysis. A total 320 1-day-old were randomly divided into two groups, with 10 replicates per group 16 birds replicate. Broilers in control received basal diet, those experimental (SBPG) diet 0.2 % SBP replacing same amount meal. The experiment lasted for 70 d. results showed that, compared group, final body weight average daily gain SBPG significantly higher (P < 0.05), feed conversion ratio was lower 0.05). Notably, improved gut chickens, including increased villus height, decreased levels proinflammatory factors, such as IL-1β interferon-γ, upregulated expression tight junction proteins, ZO-1 occludin. In addition, transcriptome sequencing revealed that exhibited significant enrichment multiple metabolic pathways, fatty acid metabolism, degradation, biosynthesis unsaturated acids Cecal 16S rRNA abundance butyrate-producing beneficial bacteria Muribaculaceae. Subsequent cecal metabolome analysis also enhanced lipid-related alpha-linolenic metabolism GPI-anchor biosynthesis. conclusion, is a potential additive can improve morphology, enhance immunity barrier function, optimize structure microbiota, function.

Language: Английский

Citations

0
Protective Effects and Mechanisms of Extracts of Gleditsia Sinensis Lam. Thorn on DSS-Induced Colitis in Mice DOI
Xiaoming Liu, Yujie Chen, Yong Liu

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 340, P. 119244 - 119244

Published: Dec. 23, 2024

Language: Английский

Citations

0