Retinal Inflammation and Reactive Müller Cells: Neurotrophins’ Release and Neuroprotective Strategies DOI Creative Commons
Bijorn Omar Balzamino, Andrea Cacciamani, Lucia Dinice

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(12), P. 1030 - 1030

Published: Dec. 9, 2024

Millions of people worldwide suffer from retinal disorders. Retinal diseases require prompt attention to restore function or reduce progressive impairments. Genetics, epigenetics, life-styling/quality and external environmental factors may contribute developing diseases. In the physiological retina, some glial cell types sustain neuron activities by guaranteeing ion homeostasis allowing effective interaction in synaptic transmission. Upon insults, cells interact with neuronal other non-neuronal cells, at least part counteracting biomolecular changes that trigger complications vision loss. Several epigenetic oxidative stress mechanisms are quickly activated release concert growth, fibrogenic angiogenic can influence overall microenvironment cell-to-cell response. Reactive Müller participate secreting neurotrophic/growth/angiogenic factors, cytokines/chemokines, cytotoxic/stress molecules neurogenic inflammation peptides. Any attempt maintain/restore condition be interrupted perpetuating vascular dysfunction neurodegeneration. Herein, we critically revise current knowledge on cell-to-mediator interplay between astrocytes microglia, respect pro-con modulators neuroprotective/detrimental activities, as observed using experimental models analyzing ocular fluids, altogether contributing a new point view field research precision medicine.

Language: Английский

Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review DOI Creative Commons
Maroua Jalouli, Md. Ataur Rahman, Partha Biswas

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 24, 2025

Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer's Disease (AD), Parkinson's (PD), Dementia, Multiple Sclerosis (MS), Stroke, Huntington's (HD). Polyphenols been extensively studied ability regulate inflammatory responses by modulating activity pro-inflammatory genes influencing signal transduction pathways, thereby reducing neuroinflammation neuronal death. Additionally, polyphenols shown promise various cellular signaling pathways associated with viability, synaptic plasticity, cognitive function. Epidemiological clinical studies highlight polyphenol-rich diets decrease risk alleviate symptoms disorders Furthermore, demonstrated through regulation key Akt, Nrf2, STAT, MAPK, play critical roles neuroprotection body's immune response. This review emphasizes growing body evidence supporting combating neurodegeneration neuroinflammation, well enhancing brain health. Despite substantial promising hypotheses, further research investigations are necessary fully understand role establish them advanced targets age-related neuroinflammatory conditions.

Language: Английский

Citations

7
Lebanese Medicinal Plants with Ophthalmic Properties DOI Creative Commons
Jeanne Andary,

Haitham El Ballouz,

Rony Abou‐Khalil

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 155 - 155

Published: Jan. 24, 2025

Lebanon benefits from a rich biodiversity, with medicinal and aromatic plants (MAPs) representing an important part of the country’s natural wealth; however, limited data are available documenting being employed in eye health. This review is first to document Lebanese ophthalmic characteristics phytochemistry that might be beneficial development new, accessible, efficient ocular medications. In this study, we searched for studies on therapeutic using known resources, including PubMed, ScienceDirect, Google Scholar, confirmed these plants’ presence within flora. The efficacy 52 species 28 families, two endemic (Crepis libanotica Salvia libanotica), has been documented. Their Latin names, regional medical applications, plant parts used, preparation forms detailed below. largest number belongs Lamiaceae family (21%), followed by Asteraceae (14%) Solanaceae (7%). most commonly used stems, leaves, seeds. Ocular treatments fall into several categories: inflammation, infection, irritation, dry-eye, eyewash, prevention or delay cataracts, general problems. A significant percentage (68%) target anterior eye. Some reported can harmful eyes should handled caution. listed, constituting local heritage global importance, could treating ailments require special screening preservation.

Language: Английский

Citations

0
Natural remedies proposed for the management of diabetic retinopathy (DR): diabetic complications DOI Creative Commons
Emad Gamil Khidr,

Nourhan Ibrahim Morad,

Shymaa Hatem

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

Abstract Diabetic retinopathy (DR) represents a significant and serious complication associated with diabetes mellitus (DM), often resulting in considerable visual impairment or even blindness. The intricate pathological processes underlying DR complicate the effectiveness of current treatment modalities. Studies have highlighted potential natural products via several beneficial effects including anti-inflammatory, antioxidant, anti-neovascular, anti-apoptotic properties. Flavonoids, saponins, saccharides, alkaloids exhibited various vivo vitro studies. However, clinical utilization these compounds is hindered by issues such as inadequate specificity, low bioavailability, toxicity. Therefore, there pressing need for rigorous studies to confirm efficacy preventing mitigating progression DR.

Language: Английский

Citations

0
The Role of Diet and Oral Supplementation for the Management of Diabetic Retinopathy and Diabetic Macular Edema: A Narrative Review DOI Creative Commons
Angela DʼAngelo, Filippo Lixi, Livio Vitiello

et al.

BioMed Research International, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Globally, diabetic retinopathy (DR) and macular edema (DME) are the leading causes of visual loss in working people. Current treatment approaches mostly target proliferative DR DME, such as intravitreal injections antivascular endothelial growth factor agents laser photocoagulation. Before progresses into more severe, sight-threatening stage, patients with early stages disease must get appropriate care. It has been suggested that nutraceuticals, which natural functional foods minimal adverse effects, may help DME. Several vitro vivo studies were carried out over last years, showing potential benefits several nutraceuticals due to their neuroprotective, vasoprotective, anti-inflammatory, antioxidant properties. Although most research is restricted animal models many have low bioavailability, these compounds adjuvate implement conventional therapies. The purpose this review (i) summarize complex pathophysiology underlying DME (ii) examine main natural-derived molecules dietary habits can assist therapies for clinical management

Language: Английский

Citations

0
Retinal Inflammation and Reactive Müller Cells: Neurotrophins’ Release and Neuroprotective Strategies DOI Creative Commons
Bijorn Omar Balzamino, Andrea Cacciamani, Lucia Dinice

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(12), P. 1030 - 1030

Published: Dec. 9, 2024

Millions of people worldwide suffer from retinal disorders. Retinal diseases require prompt attention to restore function or reduce progressive impairments. Genetics, epigenetics, life-styling/quality and external environmental factors may contribute developing diseases. In the physiological retina, some glial cell types sustain neuron activities by guaranteeing ion homeostasis allowing effective interaction in synaptic transmission. Upon insults, cells interact with neuronal other non-neuronal cells, at least part counteracting biomolecular changes that trigger complications vision loss. Several epigenetic oxidative stress mechanisms are quickly activated release concert growth, fibrogenic angiogenic can influence overall microenvironment cell-to-cell response. Reactive Müller participate secreting neurotrophic/growth/angiogenic factors, cytokines/chemokines, cytotoxic/stress molecules neurogenic inflammation peptides. Any attempt maintain/restore condition be interrupted perpetuating vascular dysfunction neurodegeneration. Herein, we critically revise current knowledge on cell-to-mediator interplay between astrocytes microglia, respect pro-con modulators neuroprotective/detrimental activities, as observed using experimental models analyzing ocular fluids, altogether contributing a new point view field research precision medicine.

Language: Английский

Citations

2