Nutrients,
Journal Year:
2024,
Volume and Issue:
16(23), P. 4074 - 4074
Published: Nov. 27, 2024
Damage
to
intestinal
epithelial
cells
is
present
in
obesity
and
other
diseases
because
of
inflammatory
oxidative
processes.
This
damage
compromises
the
gastrointestinal
barrier,
killing
enterocytes,
altering
permeability,
eliciting
abnormal
immune
responses
that
promote
chronic
inflammation.
Recent
evidence
shows
spirulina
a
potent
natural
agent
with
antioxidant
anti-inflammatory
properties.
Objectives:
study
was
conducted
evaluate
effect
aqueous
extract
(SPAE)
on
alterations
epithelium
induced
by
lipid
micelles
(LMs)
and/or
inflammation
lipopolysaccharides
(LPSs)
Caco-2
cell
line.
Methods:
In
current
research,
we
assessed
protective
actions
SPAE
against
cytotoxicity,
stress,
inflammation,
barrier
perturbation
using
an
vitro
model,
cells,
treated
LPSs
LMs.
We
also
performed
silico
molecular
docking
analysis
spirulina’s
bioactive
compound,
phycocyanobilin.
Results:
Our
results
showed
has
no
cytotoxic
cells.
On
contrary,
it
improved
viability
exhibited
actions.
protected
endoplasmic
reticulum
stress
tight
junction
proteins,
thus
improving
barrier.
The
revealed
strong
binding
affinity
phycocyanobilin
compound
human
SOD
NADPH
oxidase
good
towards
COX-2
iNOS.
Conclusions:
Taken
together,
these
findings
demonstrate
beneficial
suggesting
may
be
useful
preserving
conditions
involving
such
as
obesity.
Life,
Journal Year:
2025,
Volume and Issue:
15(2), P. 184 - 184
Published: Jan. 26, 2025
This
study
explores
the
mixotrophic
cultivation
of
Limnospira
platensis
using
dairy
byproducts,
specifically
scotta
whey
(SW),
buttermilk
wastewater
(BMW),
and
(DWW),
to
promote
biomass
production
enhance
composition
bioactive
compounds.
By
assessing
various
concentrations
(1%,
2%,
4%
v
v−1)
these
byproducts
in
a
modified
growth
medium,
this
aims
evaluate
their
effect
on
L.
growth,
phycocyanin
(C-PC)
content,
fatty
acid
methyl
ester
(FAME)
profiles.
The
results
show
that
optimal
was
achieved
with
2%
wastewater,
reaching
maximum
3.30
g
L−1
3.19
L−1,
respectively.
Mixotrophic
led
increased
C-PC
yields,
especially
treatments,
highlighting
potential
for
producing
valuable
pigments.
Additionally,
FAME
profiles
indicated
minimal
changes
compared
control,
oleic
γ-linolenic
acids
being
dominant
conditions.
These
findings
support
viability
utilizing
sustainable
cultivation,
contributing
circular
bioeconomy
while
compounds
nutritional
commercial
interest.
Applied Sciences,
Journal Year:
2025,
Volume and Issue:
15(2), P. 532 - 532
Published: Jan. 8, 2025
Arthospira
platensis
is
a
filamentous
cyanobacterium
considered
an
important
source
of
phycobiliproteins
(PBP),
class
water-soluble
pigments
with
wide
range
applications.
Although
several
extraction
and
purification
techniques
PBP
have
been
reported,
there
still
need
for
strategies
that
achieve
balance
between
simplicity,
cost-effectiveness,
scalability.
To
address
this
need,
study
systematically
evaluated
conventional
methods—homogenisation,
freeze–thaw
cycles,
maceration.
Maceration
showed
the
best
yield
purity
recovery
among
tested
techniques,
under
optimal
conditions
(three
2
h/cycle,
0.1
M
phosphate
buffer),
55.9
mg/g
biomass
phycocyanin
(PC)
24.9
allophycocyanin
(APC)
notable
antioxidant
capacity
(Folin-Ciocalteu’s
ABTS●+
assays)
were
yielded.
Among
ammonium
sulphate
fractionation
achieved
2.3
recoveries
92.9%
79.9%
PC
APC,
respectively,
while
0.5%
activated
carbon
resulted
in
extract
2.5
90.9%
87.2%
(APC).
The
suggested
procedures
could
be
fast
cost-effective
way
to
obtain
cosmetic-grade
PBP,
thus
offering
accessible
solution
industries
prioritising
sustainable
economically
viable
production
pipelines.
Separations,
Journal Year:
2024,
Volume and Issue:
11(9), P. 257 - 257
Published: Aug. 30, 2024
The
surging
popularity
of
plant-based
diets
and
the
growing
emphasis
on
clean-label
products
have
intensified
interest
in
Spirulina
within
food
industry.
As
more
people
adopt
vegetarian,
vegan,
or
flexitarian
lifestyles,
demand
for
protein
sources
has
escalated.
Spirulina’s
high
content
complete
amino
acid
profile
make
it
an
ideal
candidate
to
meet
this
demand.
However,
incorporating
into
is
not
without
its
challenges.
Its
strong,
earthy,
fishy
taste
can
be
off-putting
consumers
difficult
mask
formulations.
Furthermore,
isolating
bioactive
compounds
while
preserving
their
integrity
complex,
especially
considering
heat
sensitivity
many
these
components.
Traditional
extraction
methods
often
employ
temperatures,
which
degrade
valuable
compounds.
Consequently,
there
a
preference
non-thermal
techniques.
This
paper
provides
overview
recent
advancements
cultivation,
extraction,
application
products.
Marine Drugs,
Journal Year:
2024,
Volume and Issue:
22(9), P. 381 - 381
Published: Aug. 24, 2024
holds
promise
for
biotechnological
applications
due
to
its
rapid
growth
and
ability
produce
valuable
bioactive
compounds
like
phycocyanin
(PC).
This
study
explores
the
impact
of
salinity
brewery
wastewater
(BWW)
on
mixotrophic
cultivation
Natural Product Communications,
Journal Year:
2025,
Volume and Issue:
20(4)
Published: April 1, 2025
Background
&
Objectives:
Protein
glycation
results
in
advanced
end-products
(AGEs),
contributing
to
degenerative
diseases.
Phycocyanin
(PC),
a
natural
antioxidant,
has
potential
reduce
glycation-induced
damage.
This
study
evaluates
the
binding
interaction
of
PC
with
bovine
serum
albumin
(BSA),
its
antiglycation
efficacy,
and
associated
thermodynamic
properties.
Methods:
BSA
at
concentration
0.3
mg/mL
was
titrated
range
0
50
μM.
Fluorescence
emission
spectra
between
300
500
nm
were
measured
excitation
wavelength
280
using
spectrofluorometer
Peltier
temperature
control,
set
25,
30,
37
°C.
Binding
constants,
quenching
parameters,
values
calculated.
The
evaluated
by
measuring
protein
carbonyl
content,
fructosamine
levels,
AGE-specific
fluorescence.
Results:
analysis
demonstrated
dynamic
mechanism,
exhibiting
increased
efficiency
elevated
temperatures.
constants
confirmed
strong
BSA,
driven
hydrophobic
forces,
negative
ΔG
indicating
spontaneity.
Antiglycation
assays
revealed
reduced
levels
carbonyls,
AGE
formation.
Conclusions:
demonstratesstrong
through
interactions
effectively
inhibits
glycation-related
modifications,
highlightingits
as
therapeutic
agent
against
disorders.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(22), P. 5387 - 5387
Published: Nov. 15, 2024
With
population
growth
expected
in
the
near
future
and
planet’s
limited
resources,
alternative
food
sources
are
already
being
looked
for.
In
this
context,
spirulina
is
called
of
due
to
its
rich
nutritional
composition.
This
blue–green
alga
primarily
a
valuable
source
protein
(55–70%)
containing
all
essential
amino
acids.
composition,
it
also
contains
unsaturated
fatty
acids,
minerals,
vitamins,
pigments,
including
protein–pigment
complex—phycocyanin.
Due
high
content
complete
minerals
such
as
iron
calcium,
an
excellent
addition
diets,
especially
those
vegans
vegetarians.
Despite
several
limitations
use
spirulina,
distinctive
marine
flavour,
low
consumer
awareness,
or
relatively
price,
scientists
attempting
enrich
many
products
with
microalga.
supported
not
only
by
improved
composition
fortified
product
but
spirulina’s
impact
on
sustainable
production.
Therefore,
review
aims
create
attention
presenting
health-promoting
potential
great
significance.
