Bee Pollen as a Source of Biopharmaceuticals for Neurodegeneration and Cancer Research: A Scoping Review and Translational Prospects DOI Creative Commons

Rachid Kacemi,

María G. Campos

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 5893 - 5893

Published: Dec. 13, 2024

Bee Pollen (BP) has many advantageous properties relying on its multitargeting potential, a new tendency in managing challenging illnesses. In cancer and neurodegeneration, the multiple effects of BP could be unequaled importance need further investigation. Although still limited, available data interestingly spotlights some floral sources with promising activities line this Adopting scoping review methodology, we have identified crucial bioactivities that are widely recognized to individual compounds but remain completely untapped valuable bee cocktail. A wide range these been recently found endowed great potential modulating pivotal processes neurodegeneration pathophysiology. addition, ubiquitous only isolated, while number studied BPs remains extremely limited compared endless pool plant species worldwide. We also elucidated clinical profits from perspectives impeded by hurdles such as bioavailability phytocompounds, diversity lack phytochemical standardization BP, difficulty selective targeting pathophysiological mechanisms. finally present interesting insights guide future research pave way for urgently needed simplified investigations.

Language: Английский

Pathogenesis of Parkinson’s Disease DOI
Bin Xiao, Zhidong Zhou, Yinxia Chao

et al.

Neurologic Clinics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
Chitosan and its derivatives: A novel approach to gut microbiota modulation and immune system enhancement DOI
Great Iruoghene Edo, Alice Njolke Mafe,

Ali B. M. Ali

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 289, P. 138633 - 138633

Published: Dec. 13, 2024

Language: Английский

Citations

9
Vagus nerve stimulation and gut microbiota interactions: a novel therapeutic avenue for neuropsychiatric disorders DOI Creative Commons

Navid Faraji,

Bahareh Payami,

Negar Ebadpour

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 105990 - 105990

Published: Dec. 1, 2024

The rising prevalence of treatment-resistant neuropsychiatric disorders underscores the need for innovative and effective treatment strategies. gut microbiota (GM) plays a pivotal role in progression these diseases, influencing brain mental health through gut-brain axis (GBA). vagus nerve significant GBA, making it key area focus potential novel therapeutic interventions. Vagus stimulation (VNS) was introduced approved as refractory forms some neuropsychological disorders, such depression epilepsy. Considering its impact on several regions that play vital part mood, motivation, affection, cognitive function, VNS has shown treating variety disorders. Harnessing to target bidirectional communication pathways linking GM VN could present an exciting approach Imbalances GM, dysbiosis, can impair between brain, contributing development shows modulating interconnected systems, helping restore balance. Interestingly, composition may also influence effectiveness VNS, modify brain's response this approach. This study provides comprehensive analysis relatively unexplored but noteworthy interaction In addition, we discussed mechanisms, potential, clinical implications GBA across

Language: Английский

Citations

5
The Neuroprotective Effects of Agmatine on Parkinson’s Disease: Focus on Oxidative Stress, Inflammation and Molecular Mechanisms DOI
Mohammad Yasin Zamanian,

Mozhgan Nazifi,

Lusine Khachatryan

et al.

Inflammation, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Language: Английский

Citations

3
Promotion of a Mediterranean Diet Alters Constipation Symptoms and Fecal Calprotectin in People with Parkinson’s Disease: A Randomized Controlled Trial DOI Open Access
Carley Rusch, Matthew Beke, Carmelo Nieves

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2946 - 2946

Published: Sept. 2, 2024

Parkinson’s disease is associated with gastrointestinal (GI) dysfunction, including constipation symptoms and abnormal intestinal permeability inflammation. A Mediterranean diet (MediDiet) may aid in management. This parallel, randomized, controlled trial people (PwP) compared a MediDiet against standard of care on change symptoms, dietary intake, fecal zonulin calprotectin concentrations as markers inflammation, respectively. Participants were randomized to either for (control; n = 17, 65.1 ± 2.2 years) or plus (n 19, 68.8 1.4 8 weeks. Constipation scores decreased both interventions (p < 0.01), but changes from baseline not different between groups (MediDiet, −0.5 [−1.0, 0]; control, −0.8 0.2]; median [25th, 75th]; p 0.60). The group had higher intake fiber at week 4 than the control (13.1 0.7 g/1000 kcal vs. 9.8 kcal; 0.001). No differences observed 0.33); however, tended be lower (45.8 15.1 µg/g 93.9 26.8 µg/g; 0.05). reduced symptoms; provided additional benefit increased less

Language: Английский

Citations

2
Therapeutic potential of green tea catechins on the development of Parkinson’s disease symptoms in a transgenic A53T mouse model DOI

Elizabeth Riegelman,

Kathy S. Xue, Jia-Sheng Wang

et al.

Nutritional Neuroscience, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 17

Published: Nov. 29, 2024

Objectives: This study aimed to evaluate the effects of green tea catechins on prevention Parkinson's disease neurobehavioral symptoms and α-synuclein blood plasma concentration in a hemizygous transgenic A53T mouse model.

Language: Английский

Citations

1
Bee Pollen as a Source of Biopharmaceuticals for Neurodegeneration and Cancer Research: A Scoping Review and Translational Prospects DOI Creative Commons

Rachid Kacemi,

María G. Campos

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 5893 - 5893

Published: Dec. 13, 2024

Bee Pollen (BP) has many advantageous properties relying on its multitargeting potential, a new tendency in managing challenging illnesses. In cancer and neurodegeneration, the multiple effects of BP could be unequaled importance need further investigation. Although still limited, available data interestingly spotlights some floral sources with promising activities line this Adopting scoping review methodology, we have identified crucial bioactivities that are widely recognized to individual compounds but remain completely untapped valuable bee cocktail. A wide range these been recently found endowed great potential modulating pivotal processes neurodegeneration pathophysiology. addition, ubiquitous only isolated, while number studied BPs remains extremely limited compared endless pool plant species worldwide. We also elucidated clinical profits from perspectives impeded by hurdles such as bioavailability phytocompounds, diversity lack phytochemical standardization BP, difficulty selective targeting pathophysiological mechanisms. finally present interesting insights guide future research pave way for urgently needed simplified investigations.

Language: Английский

Citations

0