The Expanding Role of Probiotics in Human Health

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1116 - 1116

Published: March 24, 2025

Since the 1990s, it has been widely documented that probiotics, either alone or in combination with prebiotic supplements, play a vital role host health and disease management [...].

Language: Английский

Skin Protection Effects of Lactobacillus paragasseri HN910 Lysate and the Role of Alanine

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Abstract Skin aging is influenced by structural alterations, oxidative stress, inflammation, and microbiome changes, a comprehensive approach to addressing these factors may be effective for mitigating skin aging. This study evaluates the multifaceted anti-aging effects of heat-killed (HK-HN910) lysed (LS-HN910) forms Lactobacillus paragasseri HN910. Protective on cell viability, permeability, nitric oxide (NO) production, gene expression both HK-HN910 LS-HN910 were observed. Both significantly enhanced tight junction (TJ) protein zonula occludens- 1 ( ZO- ) antioxidant enzyme glutathione peroxidase GPx) expression, while downregulating that senescence-associated secretory phenotype pro-inflammatory cytokines interleukin IL - 1α , IL- 1β 6 8 tumor necrosis factor-alpha TNFα ). showed greater upregulation GPx downregulation compared HK-HN910. Cell wall component D-alanine (D-Ala) was released in higher amounts than demonstrated effects. D-Ala upregulated barrier claudin- Cla- ), occludin OCC filaggrin FLG sphingomyelin phosphodiesterase 2 SMPD2 enzymes superoxide dismutase SOD catalase CAT . treatment clinically revealed improvements parameters, including transepidermal water loss, contents, sebum levels, dermal density, eye wrinkle index, pH, brightness, microbiota composition, with significant increase Rhodococcus abundance. These findings indicate LS-HN910, containing D-Ala, promising cosmeceutical preventing enhancing barrier, promoting defense, modulating inflammatory responses, influencing microbiota.

Language: Английский

Probiotic effects on skin health: comprehensive visual analysis and perspectives

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 3, 2024

Bacteria play a crucial role in maintaining the health of human skin. Research has demonstrated that probiotics present notable benefits for extraintestinal organs. Despite extensive research on impact skin health, there is absence regulatory frameworks governing their external application, with no approval from FDA any probiotic products use. The aim this study to offer thorough summary status field since 2000 and project future trends.

Language: Английский