Therapeutic Strategies to Modulate Gut Microbial Health: Approaches for Chronic Metabolic Disorder Management

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 127 - 127

Published: Feb. 13, 2025

Numerous recent studies have suggested that the composition of intestinal microbiota can trigger metabolic disorders, such as diabetes, prediabetes, obesity, syndrome, sarcopenia, dyslipidemia, hyperhomocysteinemia, and non-alcoholic fatty liver disease. Since then, considerable effort has been made to understand link between well role probiotics in modulation microbiota. The aim this review was summarize reviews individual articles on state art regarding ideal therapy with prebiotics order obtain reversion dysbiosis (alteration microbiota) eubiosis during diseases, diseases. This includes 245 eligible studies. In conclusion, a condition dysbiosis, or general, alteration microbiota, could be implicated development disorders through different mechanisms, mainly linked release pro-inflammatory factors. Several already demonstrated potential using treatment condition, detecting significant improvements specific symptoms These findings reinforce hypothesis lead generalized inflammatory picture negative consequences organs systems. Moreover, confirms beneficial effects diseases are promising, but more research is needed determine optimal probiotic strains, doses, administration forms for conditions.

Language: Английский

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The Short- and Long-Term Effects of a Short Course of Sauerkraut Supplementation on the Gut Microbiota of Active Athletes: A Pilot Follow-Up Study

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 929 - 929

Published: March 6, 2025

Objectives: The application of whole fermented foods in sports nutrition for gut microbiota personalization is a promising area investigation. Sauerkraut, traditional food, has not been extensively studied this context. This study aimed to replicate earlier findings proof-of-concept on the potential sauerkraut active athletes. Methods: A pilot follow-up was conducted recreational athletes who consumed 250 g organic pasteurized daily 10 days. Changes composition and functionality were assessed using 16S rRNA sequencing metabolic pathway analysis across three time points: pre-intervention, postintervention, one-month postintervention. Laboratory parameters, bowel function, side effects monitored throughout study. Results: In total, 11 male participants with an average age 30 years completed did original study's sauerkraut's short-term β-diversity taxonomic functional groups. However, long-term supplementation demonstrated, including significant reduction α-diversity variance increased similarity (β-diversity) as well several changes bacterial taxa pathways after washout period. intervention also induced transient decrease B12 vitamin levels short- increase leukocyte concentrations. probability physiological types stools one week incidence gastrointestinal effects, such bloating, diarrhea, pain, nausea, constipation. Conclusions: suggests that depend its baseline status, but it can induce effects. Sauerkraut requires seven-day adaptation Further research needed explore mechanisms behind supplementation.

Language: Английский

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Interaction Between Human Microbiota, Immune System, and Hepatitis C Virus Infection: A Narrative Review

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(6), P. 3157 - 3157

Published: March 14, 2025

Hepatitis C virus (HCV) accounts for approximately 17.5% of acute hepatitis cases, with around 65% individuals progressing to chronic infection after the phase. The role intestinal microbiota in pathogenesis liver diseases associated HCV is an emerging area scientific interest. However, precise mechanisms by which influence remain inadequately understood, warranting further investigation. While comprehensive data on human microbiota–HCV interactions are limited, existing studies provide valuable insights that can inform future research and theoretical exploration. These lay foundation hypothesizing potential linking within gut–liver axis. knowledge regarding between remains insufficient; however, recent findings highlight significant axis progression its complications. possible therapeutic advantages strategies modulate microbiome, such as fecal transplantation (FMT), merit investigation relation HCV. Future should focus elucidating reciprocal relationship gut pathogenesis, identifying microbial markers linked disease advancement, assessing effectiveness microbiota-targeted therapies enhancing clinical outcomes infected This review aims summarize current understanding propose a novel perspective based literature findings, thereby paving way new initiatives infections. We surveyed described it conducting both thematic conceptual analysis.

Language: Английский

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Role of short-chain fatty acids in non-alcoholic fatty liver disease and potential therapeutic targets

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 3, 2025

Non-alcoholic fatty liver disease (NAFLD) is increasing worldwide and has become the greatest potential risk for cirrhosis hepatocellular carcinoma. The metabolites produced by gut microbiota act as signal molecules that mediate interaction between microorganisms host have biphasic effects on human health. its metabolites, short-chain acids (SCFAs), been discovered to ameliorate many prevalent diseases, including NAFLD. Currently, SCFAs attracted widespread attention therapeutic targets NAFLD, but mechanism of action not fully elucidated. This article summarizes mechanisms regulate metabolism glucose lipid, maintain intestinal barrier, alleviate inflammatory response, improve oxidative stress in order provide a reference clinical application.

Language: Английский

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Gut Microbiota and Its Metabolite Taurine-β-Muricholic Acid Contribute to Antimony- and/or Copper-Induced Liver Inflammation

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3332 - 3332

Published: April 3, 2025

Antimony and copper can contaminate vegetables enter the human body through digestive tract, inducing severe extensive biotoxicity. However, role of bile acids (BAs) in pathogenesis liver inflammation by antimony or has not been elucidated. Our results indicated that and/or induced inflammation, causing disruption gut microbiota, with down-regulation probiotics up-regulation harmful bacteria closely correlated to inflammation. Targeted metabolomics BAs showed significantly up-regulated levels taurine-β-muricholic acid (T-β-MCA) serum liver, which was due reduction Lactobacillus spp. A farnesoid X receptor (FXR) antagonist, T-β-MCA inhibited FXR-SHP pathway FXR-FGF15 ileum, thereby promoting transcription cholesterol 7-alpha hydroxylase (CYP7A1) increasing total concentrations, ultimately leading These findings provide new insights into underlying mechanisms antimony- copper-induced

Language: Английский

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Gut Mycobiome: Latest Findings and Current Knowledge Regarding Its Significance in Human Health and Disease

Journal of Fungi, Journal Year: 2025, Volume and Issue: 11(5), P. 333 - 333

Published: April 22, 2025

The gut mycobiome, the fungal component of microbiota, plays a crucial role in health and disease. Although fungi represent small fraction ecosystem, they influence immune responses, homeostasis, disease progression. mycobiome’s composition varies with age, diet, host factors, its imbalance has been linked to conditions such as inflammatory bowel (IBD) metabolic disorders. Advances sequencing have expanded our understanding fungi, but challenges remain due methodological limitations high variability between individuals. Emerging therapeutic strategies, including antifungals, probiotics, fecal microbiota transplantation, dietary interventions, show promise require further study. This review highlights recent discoveries on interactions bacteria, disease, potential clinical applications. A deeper contributions will help develop targeted microbiome-based therapies.

Language: Английский

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Could a Mediterranean Diet Modulate Alzheimer’s Disease Progression? The Role of Gut Microbiota and Metabolite Signatures in Neurodegeneration

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1559 - 1559

Published: April 29, 2025

Neurodegenerative disorders such as Alzheimer’s disease (AD), the most common form of dementia, represent a growing global health crisis, yet current treatment strategies remain primarily palliative. Recent studies have shown that neurodegeneration through complex interactions within gut–brain axis largely depends on gut microbiota and its metabolites. This review explores intricate molecular mechanisms linking dysbiosis to cognitive decline, emphasizing impact microbial metabolites, including short-chain fatty acids (SCFAs), bile acids, tryptophan neuroinflammation, blood–brain barrier (BBB) integrity, amyloid-β tau pathology. The paper highlights major microbiome signatures associated with disease, detailing their metabolic pathways inflammatory crosstalk. Dietary interventions promise in modulating composition, potentially mitigating neurodegenerative processes. critically examines influence dietary patterns, Mediterranean Western diets, microbiota-mediated neuroprotection. Bioactive compounds like prebiotics, omega-3 polyphenols exhibit neuroprotective effects by reducing neuroinflammation. Furthermore, it discusses emerging microbiome-based therapeutic strategies, probiotics, postbiotics, fecal transplantation (FMT), potential for slowing progression. Despite these advances, several knowledge gaps remain, interindividual variability responses need large-scale, longitudinal studies. study proposes an integrative, precision medicine approach, incorporating science into paradigms. Ultimately, cognizance at mechanistic level could unlock novel avenues, offering non-invasive, diet-based strategy managing improving health.

Language: Английский

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Changes in Liver Metabolome Induced by Pterostilbene and Resveratrol in a Rat Model of Liver Steatosis

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

ABSTRACT To gain more light on the effects of resveratrol and pterostilbene in hepatic metabolic modifications an vivo model diet‐induced steatosis, to explore their relationships with gut microbiota by untargeted metabolomics metagenomics. Rats were divided into five groups receiving either a standard diet or high‐fat high‐fructose (HFHF) supplemented not (15 30 mg/kg body weight/day; PT15 PT30 groups, respectively) (30 RSV30 group). Supplementation stilbenes reduced steatosis induced HFHF diet. After study, 27 differentially expressed metabolites showed variable importance projection scores > 1 could be considered as potential biomarkers. Therefore, based pathway enrichment analysis, “riboflavin metabolism” “nicotinate nicotinamide revealed significant enrichment. Further, riboflavin positive correlations Eubacterium Faecalibacterium , negative Lactobacillus Oscillospira genera. Nicotinamide mononucleotide was only positively correlated Ralstonia genus. The approach that actions prevention liver are mediated specific mechanisms action. Particularly, pterostilbene, but resveratrol, is suggested significantly enrich nicotinate pathways.

Language: Английский

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Narrative Review: Advancing Dysbiosis Treatment in Onco-Hematology with Microbiome-Based Therapeutic Approach

Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2256 - 2256

Published: Nov. 7, 2024

This review explores the complex relationship between gut dysbiosis and hematological malignancies, focusing on graft-versus-host disease (GvHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. We discuss how alterations microbial diversity composition can influence development, progression, treatment outcomes blood cancers. The mechanisms by which microbiota impacts these conditions are examined, including modulation of immune responses, production metabolites, effects intestinal barrier function. Recent advances microbiome-based therapies for treating preventing GvHD highlighted, with emphasis full ecosystem standardized donor-derived products. Overall, this underscores growing importance microbiome research hematology–oncology its potential to complement existing treatments improve thousands patients worldwide.

Language: Английский

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The Significance of Plant Nutrition in the Creation of the Intestinal Microbiota—Prevention of Chronic Diseases: A Narrative Review

Medicina, Journal Year: 2024, Volume and Issue: 60(12), P. 1969 - 1969

Published: Nov. 29, 2024

Dysbiosis of the gastrointestinal tract is most common cause disease in childhood and adulthood. The formation intestinal microbiome begins utero, composition modification during life depends mainly on various genetic, nutritional, environmental factors. main dysbiosis improper nutrition due to a short period breastfeeding, insufficient intake fresh fruits vegetables, and/or consumption large amount processed food. benefits diet based grains, legumes, fruits, vegetables are reflected reducing risk cancer, cardiovascular diseases, myocardial infarction, stroke, rheumatoid arthritis, high blood pressure, asthma, allergies, kidney stones. Anaerobic fermentation fibers produces short-chain fatty acids (SCFA) that have an anti-inflammatory role great importance shaping microbiota. Factors associated with fiber plant-based promote increased insulin sensitivity. Insulin insulin-like growth factor 1 (IGF-I) act as promoters normal pre-neoplastic tissues. Conclusion: A prevents by creating metabolites gut reduce oxidative stress.

Language: Английский

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