Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 275 - 275

Published: Jan. 13, 2025

Type 2 diabetes mellitus (T2DM), a serious metabolic disorder, is worldwide health problem due to the alarming rise in prevalence and elevated morbidity mortality. Chronic hyperglycemia, insulin resistance, ineffective effect secretion are hallmarks of T2DM, leading many secondary complications. These include, particular, cardiovascular disorders, diabetic neuropathy, nephropathy retinopathy, foot, osteoporosis, liver damage, susceptibility infections some cancers. Polyphenols such as flavonoids, phenolic acids, stilbenes, tannins, lignans constitute an extensive heterogeneous group phytochemicals fresh fruits, vegetables their products. Various vitro studies, animal model studies available clinical trials revealed that flavonoids (e.g., quercetin, kaempferol, rutin, epicatechin, genistein, daidzein, anthocyanins), acids chlorogenic, caffeic, ellagic, gallic curcumin), stilbenes resveratrol), tannins procyanidin B2, seaweed phlorotannins), pinoresinol) have ability lower enhance sensitivity improve secretion, scavenge reactive oxygen species, reduce chronic inflammation, modulate gut microbiota, alleviate complications T2DM. The interaction between polyphenols conventional antidiabetic drugs offers promising strategy management treatment especially advanced disease stages. Synergistic effects with been documented, but also antagonistic interactions may impair drug efficacy. Therefore, additional research required clarify mutual order use knowledge applications. Nevertheless, dietary can be successfully applied part supportive for they both obvious symptoms

Language: Английский

---

Current advances in the interaction mechanisms, nutritional role and functional properties of phenolic compound-starch complexes

Food Research International, Journal Year: 2025, Volume and Issue: 202, P. 115744 - 115744

Published: Jan. 13, 2025

Language: Английский

---

Agri-Food Wastes as Natural Source of Bioactive Antioxidants—Third Edition

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 198 - 198

Published: Feb. 10, 2025

The current food systems are now unsustainable due to population growth, globalization, and climate change, contributing environmental degradation social inequalities [...]

Language: Английский

---

Consequences of Dietary Olive Leaf Powder Supplementation on Growth Performance, Carcass Traits, Blood Biochemical Parameters and Gut Microbiota in Broilers

Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105087 - 105087

Published: March 1, 2025

This experiment examined the potential of olive leaf powder (OLP) as a natural growth enhancer in broiler feed and its influences on performance, carcass characteristics, blood parameters, intestinal bacterial count. A total 210 one-day-old Arbor Acres chicks were randomly allocated into three groups. The control group was given basal diet only, 2nd 3rd groups supplemented with 1 g OLP 2 OLP/kg diet, respectively. Each consisted seven replicates 10 unsexed each. experimental trial lasted for thirty-one days. Results showed that, OLP2 exhibited significant increase live body weight (LBW) at days 14 21 age, whereas OLP1 experienced considerable rise gain (BWG) between 29 31 age. Average daily intake (ADFI) considerably decreased during first 8-14 trial, but increased next 29-31 throughout entire duration (1-31 days). While, Feed conversion ratio (FCR) improved 15-31 trial. Carcass breast yields significantly supplementation, while abdominal fat content reduced. Blood analysis revealed enhances protein, albumin, globulin levels both groups, alanine transaminase (ALT), creatinine, cholesterol (TC), triglycerides (TG), very low-density lipoprotein (VLDL) Notably, immunity antioxidant markers improvement supplementation. Due to number beneficial bacteria such Lactobacillus rose all harmful (E. coli Clostridium) caecal samples declined. In conclusion, supplementation per kg demonstrated positive impact quality, lipid profile, immunity, status, raised contents chickens, making it promising promoter poultry production.

Language: Английский

---

Carbon dot superoxide dismutase nanozyme enhances reactive oxygen species scavenging in diabetic skin wound repair

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

---

Progress of Grain Polyphenols: Biological Activities, Enrichment Methods, and Applications

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

ABSTRACT Polyphenols are secondary metabolites derived from plant metabolism and possess diverse bioactivities health‐promoting functions. They extensively utilized in the food, pharmaceutical cosmetic industries, more. Recently, with increasing focus on healthy diets, grain polyphenols have been subject of extensive research. This review provides a comprehensive discussion biological functions polyphenols, which can be accomplished through modulation enzyme activities, signaling pathways, metabolic influence membrane structure. With regard to polyphenol extraction, highlights novel efficient extraction techniques. Additionally, it explores enrichment microbial action metabolism. Finally, offers summary current status future development potential food non‐food fields application. theoretical basis for research reference point their industrialization.

Language: Английский

---

Yerba Mate (Ilex paraguariensis St. Hill.) Tea May Have Cardiometabolic Beneficial Effects in Healthy and At‐Risk Subjects: A Randomized, Controlled, Blind, Crossover Trial in Nonhabitual Consumers

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

ABSTRACT Yerba mate has been reported to have antihypertensive, hypocholesterolemic, antidiabetic, or antiobesity properties. Most evidences from human trials involved intakes of high amounts by habitual consumers. Considering its increasing popularity, this study aimed at assessing the potential cardiometabolic effects moderate intake yerba nonhabitual A randomized, crossover, controlled was carried out in healthy and hypercholesterolemic subjects. Anthropometric parameters, blood pressure, lipids, glucose metabolism, inflammatory cytokines, chemokines, different markers endothelial function, as well incretins, adipocytokines, hormones were measured baseline after 8 weeks consuming a decaffeinated isotonic drink (control). After daily consumption three servings tea, colony‐stimulating factors decreased all participants. LDL‐C normocholesterolemic individuals, while control interventions elicited similar hypolipidemic action group. Ghrelin glucose‐dependent insulinotropic polypeptide (GIP) significantly intake, glucagon‐like peptide 1 (GLP‐1) adipocytokines remained unchanged. Body fat percentage tricipital skinfold only subjects, with no on total body weight. In conclusion, could exert protective consumers subjects cardiovascular risk. Trial Registration : This trial retrospectively registered ClinicalTrials (NCT06729905)

Language: Английский

---

Polyphenolic Compounds Activate SERCA1a and Attenuate Methylglyoxal- and Palmitate-Induced Impairment in Pancreatic INS-1E Beta Cells

Cells, Journal Year: 2024, Volume and Issue: 13(22), P. 1860 - 1860

Published: Nov. 9, 2024

Sarco/endoplasmic reticulum Ca

Language: Английский

---

Antioxidant and Antidiabetic Properties of Olive Pomace’s Hydro-Ethanolic Extract and Aqueous Fraction Using an Animal Model of Diabetes Produced by Streptozotocin (STZ)

Waste and Biomass Valorization, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

Language: Английский

---