Alterations in the Processing of Platelet APP (Amyloid Beta Precursor Protein) in Alzheimer Disease: The Possible Nexus DOI Creative Commons
Hayder M. Al‐kuraishy, Ghassan M. Sulaiman, Hamdoon A. Mohammed

et al.

Neuropsychopharmacology Reports, Journal Year: 2025, Volume and Issue: 45(1)

Published: Jan. 5, 2025

Alzheimer's disease (AD) is the most common neurodegenerative associated with development of dementia. The hallmarks AD neuropathology are accumulations amyloid peptide (Aβ) and neurofibrillary tangles (NFTs). Aβ derived from processing APP (amyloid beta precursor protein) by BACE1 (beta-secretase 1) γ-secretase through an amyloidogenic pathway. However, ADAM10/α-secretase (ADAM metallopeptidase domain 10) enzymes a non-amyloidogenic pathway produces soluble alpha (sAPPα), which has neuroprotective effect. It been shown that activated platelets implicated in pathogenesis AD, also increases platelet activation. Under physiological conditions, regulate synaptic plasticity increase neuronal differentiation regulation inflammatory response. overactivated contribute to AD. Activated represent main source circulating may be involved neuropathology. Therefore, there close relationship between platelets. This review discusses potential role how targeting reduce

Language: Английский

Alterations in the Processing of Platelet APP (Amyloid Beta Precursor Protein) in Alzheimer Disease: The Possible Nexus DOI Creative Commons
Hayder M. Al‐kuraishy, Ghassan M. Sulaiman, Hamdoon A. Mohammed

et al.

Neuropsychopharmacology Reports, Journal Year: 2025, Volume and Issue: 45(1)

Published: Jan. 5, 2025

Alzheimer's disease (AD) is the most common neurodegenerative associated with development of dementia. The hallmarks AD neuropathology are accumulations amyloid peptide (Aβ) and neurofibrillary tangles (NFTs). Aβ derived from processing APP (amyloid beta precursor protein) by BACE1 (beta-secretase 1) γ-secretase through an amyloidogenic pathway. However, ADAM10/α-secretase (ADAM metallopeptidase domain 10) enzymes a non-amyloidogenic pathway produces soluble alpha (sAPPα), which has neuroprotective effect. It been shown that activated platelets implicated in pathogenesis AD, also increases platelet activation. Under physiological conditions, regulate synaptic plasticity increase neuronal differentiation regulation inflammatory response. overactivated contribute to AD. Activated represent main source circulating may be involved neuropathology. Therefore, there close relationship between platelets. This review discusses potential role how targeting reduce

Language: Английский

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