From Synaptic Plasticity to Neurodegeneration: BDNF as a Transformative Target in Medicine DOI Open Access
Corneliu Toader,

Matei Serban,

Octavian Munteanu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4271 - 4271

Published: April 30, 2025

The brain-derived neurotrophic factor (BDNF) has become one of the cornerstones neuropathology, influencing synaptic plasticity, cognitive resilience, and neuronal survival. Apart from its molecular biology, BDNF is a powerful target for transformative benefit in precision medicine, leading to innovative therapeutic approaches neurodegenerative psychiatric diseases like Alzheimer's disease (AD), Parkinson's (PD), major depressive disorder (MDD), post-traumatic stress (PTSD). Nevertheless, clinical applicability obstructed by hurdles delivery, patient-specific diversity, pleiotropic signaling. Here, we summarize findings research, including regulatory pathways diagnostic/prognostic biomarkers integrative approaches. We describe delivery systems, such as lipid nanoparticle-based mRNA therapies CRISPR-dCas9-based epigenetic editing that bypass obstacles BBB (blood-brain barrier) enzymatic degradation. recent implementation multiplex panels combining biodynamic indicators with tau amyloid-β signaling markers showcases novel levels specificity both early detection potential monitoring. Humanized preclinical models iPSC-derived neurons organoids point key role neurodeveloping processes, paralleling advances bridging observation environments. Moreover, tools delivering TrkB activators or AI-based dynamic care platforms enable tailored scalable treatments. This review also aims extend framework used understanding BDNF's relevance traditional situating more work detailing actions ischemic tissues gut-brain axis context systemic health. Finally, outline roadmap incorporation BDNF-centered into worldwide healthcare, highlighting ethical issues, equity, interdisciplinary decomposition. heralds new era neuroscience revolutionizing brain health paving way advancement medicine.

Language: Английский

Could a Mediterranean Diet Modulate Alzheimer’s Disease Progression? The Role of Gut Microbiota and Metabolite Signatures in Neurodegeneration DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1559 - 1559

Published: April 29, 2025

Neurodegenerative disorders such as Alzheimer's disease (AD), the most common form of dementia, represent a growing global health crisis, yet current treatment strategies remain primarily palliative. Recent studies have shown that neurodegeneration through complex interactions within gut-brain axis largely depends on gut microbiota and its metabolites. This review explores intricate molecular mechanisms linking dysbiosis to cognitive decline, emphasizing impact microbial metabolites, including short-chain fatty acids (SCFAs), bile acids, tryptophan neuroinflammation, blood-brain barrier (BBB) integrity, amyloid-β tau pathology. The paper highlights major microbiome signatures associated with disease, detailing their metabolic pathways inflammatory crosstalk. Dietary interventions promise in modulating composition, potentially mitigating neurodegenerative processes. critically examines influence dietary patterns, Mediterranean Western diets, microbiota-mediated neuroprotection. Bioactive compounds like prebiotics, omega-3 polyphenols exhibit neuroprotective effects by reducing neuroinflammation. Furthermore, it discusses emerging microbiome-based therapeutic strategies, probiotics, postbiotics, fecal transplantation (FMT), potential for slowing progression. Despite these advances, several knowledge gaps remain, interindividual variability responses need large-scale, longitudinal studies. study proposes an integrative, precision medicine approach, incorporating science into paradigms. Ultimately, cognizance at mechanistic level could unlock novel avenues, offering non-invasive, diet-based strategy managing improving health.

Language: Английский

Citations

2

From Synaptic Plasticity to Neurodegeneration: BDNF as a Transformative Target in Medicine DOI Open Access
Corneliu Toader,

Matei Serban,

Octavian Munteanu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4271 - 4271

Published: April 30, 2025

The brain-derived neurotrophic factor (BDNF) has become one of the cornerstones neuropathology, influencing synaptic plasticity, cognitive resilience, and neuronal survival. Apart from its molecular biology, BDNF is a powerful target for transformative benefit in precision medicine, leading to innovative therapeutic approaches neurodegenerative psychiatric diseases like Alzheimer's disease (AD), Parkinson's (PD), major depressive disorder (MDD), post-traumatic stress (PTSD). Nevertheless, clinical applicability obstructed by hurdles delivery, patient-specific diversity, pleiotropic signaling. Here, we summarize findings research, including regulatory pathways diagnostic/prognostic biomarkers integrative approaches. We describe delivery systems, such as lipid nanoparticle-based mRNA therapies CRISPR-dCas9-based epigenetic editing that bypass obstacles BBB (blood-brain barrier) enzymatic degradation. recent implementation multiplex panels combining biodynamic indicators with tau amyloid-β signaling markers showcases novel levels specificity both early detection potential monitoring. Humanized preclinical models iPSC-derived neurons organoids point key role neurodeveloping processes, paralleling advances bridging observation environments. Moreover, tools delivering TrkB activators or AI-based dynamic care platforms enable tailored scalable treatments. This review also aims extend framework used understanding BDNF's relevance traditional situating more work detailing actions ischemic tissues gut-brain axis context systemic health. Finally, outline roadmap incorporation BDNF-centered into worldwide healthcare, highlighting ethical issues, equity, interdisciplinary decomposition. heralds new era neuroscience revolutionizing brain health paving way advancement medicine.

Language: Английский

Citations

2