Current Topics in Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
23(12), P. 1104 - 1122
Published: Feb. 1, 2023
Abstract:
Tumor-associated
macrophages
(TAMs)
play
a
pivotal
role
in
the
progression
and
re-sistance
of
tumors
to
different
anticancer
drugs.
TAMs
can
modulate
tumor
microenvironment
(TME)
favor
immune
system
exhaustion.
The
interactions
with
TME
affect
function
cytotoxic
CD8+
T
lymphocytes
(CTLs)
natural
killer
(NK)
cells.
Furthermore,
induce
cancer
cell
proliferation
by
releasing
some
growth
factors,
such
as
transforming
factor
(TGF)-β.
have
several
positive
cross-talks
other
suppressive
cells
regulatory
(Tregs),
myeloid-derived
suppressor
(MDSCs),
cancer-associated
fibroblasts
(CAFs),
cells,
leading
release
prolif-eration
growth.
These
also
invasion
migration
angiogenesis,
metastasis.
inhibition
is
an
intriguing
strategy
for
overcoming
resistance
suppression
Some
natural-derived
agents
melatonin,
curcumin,
resveratrol,
apigenin,
flavonoids
shown
ability
TME,
including
TAMs.
adjuvants
may
be
able
boost
antitumor
immunity
through
modulation
This
review
explains
modulatory
effects
well-known
naturally
derived
on
activity
these
useful
suppressing
invasion.
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(8), P. 1661 - 1661
Published: April 16, 2022
Due
to
its
stimulatory
effects,
caffeine
is
one
of
the
most
frequently
consumed
mood
and
behavior
altering
drugs.
University
students
report
using
caffeine-containing
products
enhance
performance
or
for
a
desire
alertness.
The
current
study
investigated
consumption
in
university
undergraduate
students,
associations
with
smoking
status,
alcohol
cannabis
consumption,
fruit
vegetable
sleep
quality.
Motivations
intake
were
also
ascertained.
A
total
886
undergraduates
aged
18−25
years
from
Balearic
Islands
participated
cross-sectional
survey.
Caffeine
was
by
91.1%
participants.
consumers
more
likely
be
female,
smokers,
consumers.
Coffee
found
main
source
both
men
women
(48.9%
intake).
Higher
percentages
coffee
(56.4
vs.
42.1%,
p
=
0.01)
tea
(40.3
19.8%,
<
0.001),
whereas
higher
percentage
energy
drinks
(18.0
7.4%,
0.001).
Main
motivations
those
related
cognitive
enhancement.
associated
poorer
subjective
quality
(p
In
conclusion,
that
female
smokers
reported
intakes.
as
contributor,
contributions
men.
Universities
should
consider
implementation
health
campaigns
educational
programs
educate
risks
high
together
behaviors
such
smoking,
poor
physical
academic
performance.
Journal of Translational Medicine,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: March 16, 2022
Abstract
Background
Osteoporosis
is
a
disease
threatening
the
health
of
millions
individuals.
Melatonin
found
to
be
potential
anti-osteoporosis
drug.
However,
whether
melatonin
plays
role
against
osteoporosis
at
different
stages
menopause
and
underlying
mechanisms
are
unknown.
Methods
Ovariectomy
was
utilized
as
model
perimenopausal
postmenopausal
osteoporosis.
A
total
100
mg/kg
melatonin,
or
solvent
alone,
added
drinking
water
rats
over
8
weeks.
Perimenopausal
immediately
received
intervention
following
ovariectomy
while
weeks
after
ovariectomy.
All
underwent
overdose
anesthesia
which
blood
samples
femurs
were
collected
for
further
analysis.
Rat
scanned
using
micro-CT
examined
histologically.
The
serum
levels
osteogenic
biochemical
markers
measured
expression
osteogenesis-associated
genes
(
Runx2
,
Sp7
)
quantified
by
real-time
quantitative
PCR.
Alkaline
phosphatase
(ALP)
activity
gene
Col1a1
Alpl
Bglap
bone
marrow
mesenchymal
stem
cells
(BMSCs)
osteogenically
induced,
both
with
without
in
vitro.
ALP
staining
Alizarin
Red
S
used
identify
osteogenesis.
Results
Analysis
histological
demonstrated
that
mass
decreased
microarchitecture
deteriorated
time
Intervention
increased
normal,
perimenopausal,
osteoporotic
rats.
Serum
continuously
osteocalcin
initially
rose,
then
decreased.
mRNA
normal
rats,
opposite
In
vitro
study
μmol/L
three
and/or
seven
days
intervention,
14
d
intervention.
extent
matrix
mineralization
late
stage
Conclusions
Bone
ovariectomy,
ameliorated
metabolism
due
induction
differentiation
BMSCs.
Systems Biology in Reproductive Medicine,
Journal Year:
2022,
Volume and Issue:
68(5-6), P. 331 - 347
Published: June 19, 2022
Under
normal
conditions,
to
achieve
optimal
spermatogenesis,
the
temperature
of
testes
should
be
2-6
°C
lower
than
body
temperature.
Cryptorchidism
is
one
common
pathogenic
factors
male
infertility.
The
increase
testicular
in
cryptorchidism
patients
leads
disorder
regulation
and
balance,
induces
oxidative
stress
response
germ
cells,
destroys
integrity
sperm
DNA,
yields
morphologically
abnormal
sperm,
excessive
apoptosis
cells.
These
physiological
changes
can
reduce
fertility
lead
This
paper
describes
causing
heat
stress,
including
lifestyle
behavioral
factors,
occupational
environmental
(external
factors),
clinical
caused
by
pathological
conditions
(internal
factors).
Studies
have
shown
that
wearing
tight
pants
or
an
inappropriate
posture
when
sitting
for
a
long
time
daily
life,
ambient
different
seasons
areas,
cause
temperature,
response,
fertility.
occurrence
causes
within
testis
such
as
increased
cell
apoptosis,
DNA
damage
gene
expression,
chromosome
aneuploidy,
Na+/K+-ATPase
activity,
etc.
At
end
article,
we
list
some
substances
relieve
tissues,
trigonelline,
melatonin,
R.
apetalus,
angelica
powder.
protect
tissue
stress.
Current Topics in Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
23(12), P. 1104 - 1122
Published: Feb. 1, 2023
Abstract:
Tumor-associated
macrophages
(TAMs)
play
a
pivotal
role
in
the
progression
and
re-sistance
of
tumors
to
different
anticancer
drugs.
TAMs
can
modulate
tumor
microenvironment
(TME)
favor
immune
system
exhaustion.
The
interactions
with
TME
affect
function
cytotoxic
CD8+
T
lymphocytes
(CTLs)
natural
killer
(NK)
cells.
Furthermore,
induce
cancer
cell
proliferation
by
releasing
some
growth
factors,
such
as
transforming
factor
(TGF)-β.
have
several
positive
cross-talks
other
suppressive
cells
regulatory
(Tregs),
myeloid-derived
suppressor
(MDSCs),
cancer-associated
fibroblasts
(CAFs),
cells,
leading
release
prolif-eration
growth.
These
also
invasion
migration
angiogenesis,
metastasis.
inhibition
is
an
intriguing
strategy
for
overcoming
resistance
suppression
Some
natural-derived
agents
melatonin,
curcumin,
resveratrol,
apigenin,
flavonoids
shown
ability
TME,
including
TAMs.
adjuvants
may
be
able
boost
antitumor
immunity
through
modulation
This
review
explains
modulatory
effects
well-known
naturally
derived
on
activity
these
useful
suppressing
invasion.
