Chemical and Pharmacological Aspects of Caffeic Acid and Its Activity in Hepatocarcinoma

Frontiers in Oncology, Journal Year: 2019, Volume and Issue: 9

Published: June 21, 2019

Caffeic acid (CA) is a phenolic compound synthesized by all plant species and present in foods such as coffee, wine, tea popular medicines propolis. This its derivatives have antioxidant, anti-inflammatory anticarcinogenic activity. In vitro vivo studies demonstrated the activity of this against an important type cancer, hepatocarcinoma (HCC), considered to be high incidence, highly aggressive causing considerable mortality across world. The anticancer properties CA are associated with antioxidant pro-oxidant capacity, attributed chemical structure that has free hydroxyls, number position OH catechol group double bond carbonic chain. Pharmacokinetic indicate hydrolyzed microflora colonies metabolized mainly intestinal mucosa through phase II enzymes, submitted conjugation methylation processes, forming sulphated, glucuronic / or methylated conjugates action sulfotransferases, UDP-glucotransferases, o-methyltransferases, respectively. transmembrane flux cells occurs active transport mediated monocarboxylic carriers. can act preventing production ROS (reactive oxygen species), inducing DNA oxidation cancer cells, well reducing tumor cell angiogenesis, blocking STATS (transcription factor signal translation 3) suppression MMP2 MMP-9 (collagen IV metalloproteases). Thus, review provides overview pharmacological parameters derivatives, demonstrating mechanism pharmacokinetic aspects, critical analysis fight hepatocarcinoma.

Language: Английский

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Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1

Oxidative Medicine and Cellular Longevity, Journal Year: 2018, Volume and Issue: 2018(1)

Published: Jan. 1, 2018

Alzheimer’s disease (AD) is a progressive and neurodegenerative disorder of the cortex hippocampus, which eventually leads to cognitive impairment. Although etiology AD remains unclear, presence β ‐amyloid (A ) peptides in these learning memory regions hallmark AD. Therefore, inhibition A peptide aggregation has been considered primary therapeutic strategy for treatment. Many studies have shown that resveratrol antioxidant, anti‐inflammatory, neuroprotective properties can decrease toxicity hippocampus patients, promote neurogenesis, prevent hippocampal damage. In addition, antioxidant activity plays an important role neuronal differentiation through activation silent information regulator‐1 (SIRT1). SIRT1 vital growth neurons prevents apoptotic death by deacetylating repressing p53 activity; however, exact mechanisms remain unclear. Resveratrol also anti‐inflammatory effects as it suppresses M1 microglia activation, involved initiation neurodegeneration, promotes Th2 responses increasing cytokines expression. This review will focus on resveratrol, specifically its association with pathophysiology.

Language: Английский

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Gestational Diabetes Mellitus and Diet: A Systematic Review and Meta-analysis of Randomized Controlled Trials Examining the Impact of Modified Dietary Interventions on Maternal Glucose Control and Neonatal Birth Weight

Diabetes Care, Journal Year: 2018, Volume and Issue: 41(7), P. 1346 - 1361

Published: June 14, 2018

OBJECTIVE Medical nutrition therapy is a mainstay of gestational diabetes mellitus (GDM) treatment. However, data are limited regarding the optimal diet for achieving euglycemia and improved perinatal outcomes. This study aims to investigate whether modified dietary interventions associated with glycemia and/or birth weight outcomes in women GDM when compared control interventions. RESEARCH DESIGN AND METHODS Data from published randomized controlled trials that reported on components, maternal glycemia, were gathered 12 databases. extracted duplicate using prespecified forms. RESULTS From 2,269 records screened, 18 involving 1,151 included. Pooled analysis demonstrated subjects, there was larger decrease fasting postprandial glucose (−4.07 mg/dL [95% CI −7.58, −0.57]; P = 0.02 −7.78 −12.27, −3.29]; 0.0007, respectively) lower need medication treatment (relative risk 0.65 0.47, 0.88]; 0.006). For neonatal outcomes, 16 including 841 participants showed infant (−170.62 g −333.64, −7.60]; 0.04) less macrosomia 0.49 0.27, 0.02). The quality evidence these low very low. Baseline differences between groups may have influenced glucose-related As well, relatively small numbers limit between-diet comparison. CONCLUSIONS Modified favorably related weight. indicates room improvement usual advice GDM.

Language: Английский

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Role of Phytochemicals in Cancer Chemoprevention: Insights

Antioxidants, Journal Year: 2021, Volume and Issue: 10(9), P. 1455 - 1455

Published: Sept. 14, 2021

Cancer is a condition where the body cells multiply in an uncontrollable manner. Chemoprevention of cancer broad term that describes involvement external agents to slow down or suppress growth. Synthetic and natural compounds are found useful chemoprevention. The occurrence global type varies, depending on many factors such as environmental, lifestyle, genetic etc. often preventable developed countries with advanced treatment modalities, whereas it painful death sentence developing low-income due lack modern therapies awareness. One best practice identify control measures study origin risk associated common types. Based these health status patients, stage, severity cancer, decided. Even though there well-established therapies, still stands one major causes public burden globally. Research shows most cancers can be prevented, treated, incidence delayed. Phytochemicals from various medicinal plants were reported reduce different types through their chemopreventive role. This review highlights role bioactive products chemoprevention cancer. There plant based dietary involved process. discusses process carcinogenesis using phytocompounds, special reference five phytocompounds. article also summarizes important mechanisms signaling molecules Since antioxidants inevitable, insight into plant-based antioxidant fight against this dreadful disease at stages progression discussed. will fill research gap search encourage scientists clinical trials anticancer plants.

Language: Английский

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Polyphenols in the treatment of autoimmune diseases

Autoimmunity Reviews, Journal Year: 2019, Volume and Issue: 18(7), P. 647 - 657

Published: May 3, 2019

Language: Английский

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A Review of Resveratrol as a Potent Chemoprotective and Synergistic Agent in Cancer Chemotherapy

Frontiers in Pharmacology, Journal Year: 2019, Volume and Issue: 9

Published: Jan. 9, 2019

Background: Cancer has become a major disease endangering human health around the world. Conventional chemotherapy suffers from many side effects including pain, cardiotoxicity, hepatotoxicity and renal toxicity. This review aims to describe natural product of resveratrol as chemoprotective synergistic agent in modulation cancer chemotherapy. Methods: The publications were identified by comprehensive searching SciFinder, PubMed, Web Science, our own reference library. Search terms included combinations "resveratrol", "cancer", "natural products", "chemotherapy", "side effects". Selection material focused on reducing Results: 31 references referred this outline potent chemotherapy, 22 papers for describing effects, 9 illustrating effects. Conclusion: study provides systematic summary serving reduce associated-side enhance therapeutic outcomes Further studies large amount preclinical tests clinical trials are highly demanded.

Language: Английский

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Targeting Nrf2 signaling pathway and oxidative stress by resveratrol for Parkinson’s disease: an overview and update on new developments

Molecular Biology Reports, Journal Year: 2023, Volume and Issue: 50(6), P. 5455 - 5464

Published: May 8, 2023

Language: Английский

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Drug delivery systems for resveratrol, a non-flavonoid polyphenol: Emerging evidence in last decades

Journal of Drug Delivery Science and Technology, Journal Year: 2019, Volume and Issue: 51, P. 591 - 604

Published: March 20, 2019

Language: Английский

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Zein-polysaccharide nanoparticles as matrices for antioxidant compounds: A strategy for prevention of chronic degenerative diseases

Food Research International, Journal Year: 2018, Volume and Issue: 111, P. 451 - 471

Published: May 25, 2018

Language: Английский

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Recent Advances on the Anti-Inflammatory and Antioxidant Properties of Red Grape Polyphenols: In Vitro and In Vivo Studies

Antioxidants, Journal Year: 2019, Volume and Issue: 9(1), P. 35 - 35

Published: Dec. 31, 2019

In this review, special emphasis will be placed on red grape polyphenols for their antioxidant and anti-inflammatory activities. Therefore, capacity to inhibit major pathways responsible activation of oxidative systems expression release proinflammatory cytokines chemokines discussed. Furthermore, regulation immune cells by illustrated with reference the T regulatory which support a tolerogenic pathway at intestinal level. Additionally, effects analyzed in obesity, as low-grade systemic inflammation. Also, possible modifications inflammatory bowel disease biomarkers clinical course have been studied upon polyphenol administration, either animal models or trials. Moreover, ability cross blood–brain barrier has exploited investigate neuroprotective properties. cancer, seem exert several beneficial effects, even if conflicting data are reported about influence cells. Finally, evaluated experimental allergy autoimmune diseases. Conclusively, endowed great potential but some issues, such bioavailability, activity metabolites, interaction microbiota, deserve deeper studies.

Language: Английский

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