Combretastatin A4-based coumarins: synthesis, anticancer, oxidative stress-relieving, anti-inflammatory, biosafety, and in silico analysis

Chemical Papers, Journal Year: 2024, Volume and Issue: 78(6), P. 3705 - 3720

Published: Feb. 18, 2024

Language: Английский

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6,7-Coumarin-heterocyclic hybrids: A comprehensive review of their natural sources, synthetic approaches, and bioactivity

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1303, P. 137601 - 137601

Published: Jan. 22, 2024

Language: Английский

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Coumarin hybrids for targeted therapies: A promising approach for potential drug candidates

Phytochemistry Letters, Journal Year: 2024, Volume and Issue: 60, P. 117 - 133

Published: Feb. 8, 2024

Language: Английский

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Food-Derived Micronutrients as Alleviators of Age-Related Dysfunction: A Dive into Their Effects and Cellular Mechanisms

Indian Journal of Clinical Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Language: Английский

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Recent advances in nanotechnology for Parkinson’s disease: diagnosis, treatment, and future perspectives

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 22, 2025

Parkinson’s disease is a progressive neurodegenerative that destroys substantia nigra dopaminergic neurons, causing tremors, bradykinesia, rigidity, and postural instability. Current treatment approaches primarily focus on symptom management, employing pharmacological, non-pharmacological, surgical methods. However, these treatments often result in fluctuating symptoms, side effects, progression. Here, the authors have reviewed emerging field of nanomedicine as promising path for treatment, emphasizing its potential to overcome limitations traditional therapies. Nanomedicine utilizes nanoparticles targeted drug delivery, leveraging their small size high surface area volume ratio cross blood-brain barrier deliver therapeutic agents directly affected brain regions. Various nanoparticles, including lipid-based, polymeric, metallic, carbon-based, shown treatment. Additionally, nanocarrier systems like liposomes, nanogels, dendrimers, solid lipid offer controlled sustained release agents, enhancing bioavailability reducing effects. This review provides insights into pathophysiology disease, highlighting mechanisms neurodegeneration, role alpha-synuclein, disruption pathways. It further discusses application gene therapy conjunction with interventions.

Language: Английский

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Synthesis, in silico analysis, and biomedical effects of coumarins derived from resveratrol

Phytomedicine Plus, Journal Year: 2023, Volume and Issue: 3(4), P. 100501 - 100501

Published: Nov. 1, 2023

: Resveratrol (RVL) is a polyphenol-containing natural product found in variety of plants, including peanuts, grapes, and berry fruits. The use RVL linked great deal research to number therapeutic properties. In an attempt improve these properties, five RVL-based coumarins, abbreviated YF1-YF5, were synthesized structurally constructed pathway. molecular architecture our coumarins was confirmed by analyzing their FTIR NMR spectra. biomedical effects the investigated compared with precursor. first dual 5-LOX/COX inhibitory effect, which tested versus three related enzymes. second free-radical neutralizing estimated against two radical phenotypes. third apoptotic-inducing evaluated four tumorous cell lines. fourth high blood-glucose regulatory effect assessed corresponding Finally, bacterial growth-suppressing pathogenic strains. pharmacokinetic identifiers compounds also silico matched analyze chemical functionalization. findings indicated that exhibited enhanced building moiety. best reported for YF3, lowest attributed YF5. This improvement coupled advancements identifiers. According outcomes, authors concluded provide intriguing modification improving its effects.

Language: Английский

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Coumarins derived from natural methoxystilbene as oxidative stress-related disease alleviators: Synthesis and in vitro-in silico study

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1302, P. 137471 - 137471

Published: Dec. 31, 2023

Language: Английский

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Nutraceutical-based telomerase inhibitors: Renewed hope for cancer therapy

Phytomedicine Plus, Journal Year: 2024, Volume and Issue: 4(2), P. 100537 - 100537

Published: Feb. 20, 2024

: Attributes of potential targets for anticancer therapy are currently being investigated telomeres, telomerase, and their combined complex. Telomerase (TRTase) is a distinct reverse transcriptase that thought to be the leader in almost all cancer-derived cells primarily charge controlling telomere (TLM) length. This enzyme therefore guarantees unabated cell division during carcinogenesis, characteristic cancer, this distinguishing factor has made TRTase spotlight target pharmaceutical research cancer therapy. The capacity nutraceuticals inhibit TRTase, impair TLMs, hinder complex formation offers window opportunity discovery new cancer-treatment targets. review attempts provide fundamental understanding TLM investigation, regulatory frameworks, diverse binding proteins TLM-TRTase structure. Moreover, study highlights address inhibition at molecular level, inhibitors catalytic subunits. thorough knowledge TRTase's physiological action will offer crucial information boosting effectiveness plausible chemotherapeutic drug designs.

Language: Английский

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Progress in the Treatment of Central Nervous System Diseases Based on Nanosized Traditional Chinese Medicine

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 28, 2024

Abstract Traditional Chinese Medicine (TCM) is widely used in clinical practice to treat diseases related central nervous system (CNS) damage. However, the blood‐brain barrier (BBB) constitutes a significant impediment effective delivery of TCM, thus substantially diminishing its efficacy. Advances nanotechnology and applications TCM (also known as nano‐TCM) can deliver active ingredients or components across BBB targeted brain region. This review provides an overview physiological pathological mechanisms systematically classifies common CNS types nanocarriers that effectively brain. Additionally, drug strategies for nano‐TCMs utilize vivo properties vitro devices bypass cross are discussed. further focuses on application treatment various diseases. Finally, this article anticipates design strategy with higher efficiency probes their potential treating wider range

Language: Английский

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Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(3), P. 1400 - 1461

Published: Jan. 17, 2024

Abstract Neuropsychiatric disorders are anticipated to be a leading health concern in the near future, emphasizing an outstanding need for development of new effective therapeutics treat them. Stilbenes, with resveratrol attracting most attention, example multi‐target compounds promising therapeutic potential broad array neuropsychiatric and neurological conditions. This review is comprehensive summary current state research on stilbenes several such as depression, anxiety, schizophrenia, autism spectrum disorders, epilepsy, traumatic brain injury, neurodegenerative disorders. We describe discuss results both vitro vivo studies. The majority studies concentrate resveratrol, limited findings exploring other pterostilbene, piceatannol, polydatin, tetrahydroxystilbene glucoside, or synthetic derivatives. Overall, although extensive preclinical show benefits various central nervous system clinical evidence their efficacy largely missing.

Language: Английский

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