Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges DOI Creative Commons
Bruno Špiljak, Petar Ozretić, Ana Andabak Rogulj

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(23), P. 11405 - 11405

Published: Dec. 7, 2024

This study aims to evaluate the potential benefits and challenges of integrating oral microbiome research into clinical management potentially malignant disorders (OPMD) squamous cell carcinoma (OSCC). The has gained significant attention for its role in pathogenesis progression these conditions, with emerging evidence suggesting value as a diagnostic prognostic tool. By critically analyzing current methodological considerations, this manuscript examines whether analysis biopsy samples can aid early detection, prognosis, OPMD OSCC. complexity dynamic nature require multifaceted approach fully understand utility. Based on review, we conclude that studying context holds promise but also faces notable challenges, including variability need standardization. Ultimately, addresses question, “Should such be undertaken, given intricate interactions various factors inherent obstacles involved?”, emphasizes importance further optimize applications improve patient outcomes.

Language: Английский

Effects of Oleanolic Acid Derived from Wine Pomace on Periodontopathic Bacterial Growth in Healthy Individuals: A Randomized Placebo-Controlled Study DOI Creative Commons

Kyoko Shimazu,

Kouta Ookoshi,

Satoshi Fukumitsu

et al.

Dentistry Journal, Journal Year: 2024, Volume and Issue: 12(5), P. 133 - 133

Published: May 8, 2024

Periodontal disease is caused by oral pathogenic bacteria and associated with systemic frailty. Therefore, its prevention crucial in extending healthy life expectancy. This study aimed to evaluate the effect of orally administered oleanolic acid, extracted from wine pomace, on periodontopathic bacterial growth individuals. In this randomized, placebo-controlled, double-blind, parallel-group comparison study, 84 adults were assigned a placebo (

Language: Английский

Citations

0

Circ_0005397/miR-326 and linc00152/miR-216b share the signaling pathway of PDK2 to promote pancreatic adenocarcinoma oncogenesis DOI Creative Commons

Yuan Wei,

Ping Zhu

Archives of Medical Science, Journal Year: 2024, Volume and Issue: 20(4), P. 1363 - 1369

Published: Aug. 4, 2024

1. Wang B, Deng J, Donati V, et al. The roles and interactions of porphyromonas gingivalis fusobacterium nucleatum in oral gastrointestinal carcinogenesis: a narrative review. Pathogens 2024; 13: 93. Google Scholar

Language: Английский

Citations

0

Oral Pathogens’ Substantial Burden on Cancer, Cardiovascular Diseases, Alzheimer’s, Diabetes, and Other Systemic Diseases: A Public Health Crisis—A Comprehensive Review DOI Creative Commons
Peter E. Murray, Jonathan Coffman, Franklin García‐Godoy

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(12), P. 1084 - 1084

Published: Dec. 9, 2024

This review synthesizes the findings from 252 studies to explore relationship between oral pathogens associated with periodontitis, dental caries, and systemic diseases. Individuals diseases, such as are 1.7 7.5 times (average 3.3 times) more likely develop diseases or suffer adverse pregnancy outcomes, underscoring critical connection overall health. Oral conditions periodontitis caries represent a significant health burden, affecting 26–47% of Americans. The most important pathogens, ranked by publication frequency, include herpes virus, C. albicans, S. mutans, P. gingivalis, F. nucleatum, A. actinomycetemcomitans, intermedia, T. denticola, forsythia. disorders linked infections, similarly, cancer, respiratory, liver, bowel, fever, kidney, complications in pregnancy, cardiovascular bacteremia, diabetes, arthritis, autoimmune, bladder, dementia, lupus, Alzheimer’s Evidence supports efficacy periodontal treatments eliminating infections reducing severity substantial burden that have on Alzheimer’s, other poses public crisis.

Language: Английский

Citations

0

Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges DOI Creative Commons
Bruno Špiljak, Petar Ozretić, Ana Andabak Rogulj

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(23), P. 11405 - 11405

Published: Dec. 7, 2024

This study aims to evaluate the potential benefits and challenges of integrating oral microbiome research into clinical management potentially malignant disorders (OPMD) squamous cell carcinoma (OSCC). The has gained significant attention for its role in pathogenesis progression these conditions, with emerging evidence suggesting value as a diagnostic prognostic tool. By critically analyzing current methodological considerations, this manuscript examines whether analysis biopsy samples can aid early detection, prognosis, OPMD OSCC. complexity dynamic nature require multifaceted approach fully understand utility. Based on review, we conclude that studying context holds promise but also faces notable challenges, including variability need standardization. Ultimately, addresses question, “Should such be undertaken, given intricate interactions various factors inherent obstacles involved?”, emphasizes importance further optimize applications improve patient outcomes.

Language: Английский

Citations

0