Regulation of Ergosterol Biosynthesis in Pathogenic Fungi: Opportunities for Therapeutic Development DOI Creative Commons
Lijiang Song, Sha Wang, Hang Zou

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 862 - 862

Published: April 10, 2025

Ergosterol plays a dual role in fungal pathogenesis and azole resistance, driving key advancements the understanding of its biosynthesis regulation. This review integrates latest research progress on regulation ergosterol drug resistance pathogenicity. We comprehensively discuss functions enzymes (such as Erg11p/Cyp51A, Erg6p, Erg3p, Erg25p) mevalonate, late, alternative pathways. Notably, we highlight complex cyp51A expression by factors such SrbA, AtrR, CBC, HapX, NCT Aspergillus fumigatus, elucidate distinctive roles Upc2, Adr1, Rpn4 Candida species. Importantly, summarize recent discoveries CprA-dependent Cyp51A/Erg11p heme-mediated stability control. Based these findings, propose innovative antifungal strategies, including dual-target inhibition multi-enzyme natural products, which provide novel insights potential directions for development next-generation therapies.

Language: Английский

Unraveling the Nano World in Paracoccidioidomycosis: Promising Applications of Nanotechnology in Diagnosis, Treatment, and Vaccines: A Mini Review DOI
Ricardo Cervini, Ariana Centa, Claudriana Locatelli

et al.

Current Microbiology, Journal Year: 2025, Volume and Issue: 82(6)

Published: April 28, 2025

Language: Английский

Citations

0
A cell wall-targeting urease-derived peptide as a potential antifungal agent against Candida species DOI Creative Commons
Ana Paula A. Perin, Júlia Catarina Vieira Reuwsaat, Heryk Motta

et al.

Current Research in Microbial Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 100399 - 100399

Published: May 1, 2025

Language: Английский

Citations

0
Regulation of Ergosterol Biosynthesis in Pathogenic Fungi: Opportunities for Therapeutic Development DOI Creative Commons
Lijiang Song, Sha Wang, Hang Zou

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 862 - 862

Published: April 10, 2025

Ergosterol plays a dual role in fungal pathogenesis and azole resistance, driving key advancements the understanding of its biosynthesis regulation. This review integrates latest research progress on regulation ergosterol drug resistance pathogenicity. We comprehensively discuss functions enzymes (such as Erg11p/Cyp51A, Erg6p, Erg3p, Erg25p) mevalonate, late, alternative pathways. Notably, we highlight complex cyp51A expression by factors such SrbA, AtrR, CBC, HapX, NCT Aspergillus fumigatus, elucidate distinctive roles Upc2, Adr1, Rpn4 Candida species. Importantly, summarize recent discoveries CprA-dependent Cyp51A/Erg11p heme-mediated stability control. Based these findings, propose innovative antifungal strategies, including dual-target inhibition multi-enzyme natural products, which provide novel insights potential directions for development next-generation therapies.

Language: Английский

Citations

0