Evaluating the biological (antidiabetic) potential of TEM, FTIR, XRD, and UV‐spectra observed berberis lyceum conjugated silver nanoparticles

Microscopy Research and Technique, Journal Year: 2024, Volume and Issue: 87(6), P. 1286 - 1305

Published: Feb. 14, 2024

Abstract Diabetes is a life‐threatening disease that affects different parts of the body including liver, kidney, and pancreas. The core root diabetes mainly linked to oxidative stress produced by reactive oxygen species (ROS). Berberis lyceum Royle (BLR) source natural products. It comprises numerous bioactive compounds having antioxidant activities. In current investigation, silver nanoparticles from BLR extract were synthesized, characterized, assessed for antidiabetic potential. UV spectrophotometry, Transmission electron microscopy (TEM), Fourier transform infra‐red spectroscopy (FTIR), x‐ray diffraction (XRD) applied characterization NPs. was evident morphological studies synthesized NPs spherical average size 11.02 nm. Results revealed BLR‐AgNPs showed higher radical scavenging activity as compared extract. Moreover, displayed superior in vivo vitro comparison Glucose level (116.5 ± 5.1 mg/dL), liver function test (ALAT: 54.038 6.2 IU/L; ASAT: 104.42 13.9 ALP: 192.6 2.4 bilirubin: 1.434 0.14 mg/dL; total protein: 5.14 0.24 renal (urea: 39.6 0.63 uric acid: 21.4 0.94 creatinine: 0.798 0.03 albumin: 4.14 0.2 lipid profile (cholesterol: 101.62 3 triglyceride: 110.42 7 HDL‐C: 29.7 LDL‐C: 47.056 1 VLDL‐C: 22.0 1.3 mg/dL) hematology (WBCs: 3.82 10 /μL; RBCs: 4.78 0.42 6 Hb: 12.6 1.0 g/dL; Hematocrit: 39.4 3.7%; MCV: 65.8 fL; platelets: 312 22.4; neutrophils: 34.8 1.87; eosinophils: 3.08 0.43; monocytes: 0.28; lymphocytes: 75.6 3.77) confirmed significant potential BLR‐AgNPs. Histopathological examination authenticated caused revival morphology Hence, findings study suggested potent agent could be an appropriate nanomedicine prevent future. Research Highlights reducing, capping, stabilization synthesis Evaluation α‐amylase inhibition, antioxidant, α‐glucosidase inhibition Thorough using infrared spectroscopy, microscopy, diffraction, UV–VIS spectrophotometer, which st its kind In‐vivo evaluation through multiple biomarkers

Language: Английский

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Insights of biopolymeric blended formulations for diabetic wound healing

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 656, P. 124099 - 124099

Published: April 16, 2024

Language: Английский

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Prognostic value of angiography-derived microcirculatory resistance in patients undergoing rotational atherectomy- a multi-center study

International Journal of Cardiology, Journal Year: 2025, Volume and Issue: unknown, P. 133322 - 133322

Published: April 1, 2025

Language: Английский

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Red blood cells as biomarkers and mediators in complications of diabetes mellitus: A review

Medicine, Journal Year: 2024, Volume and Issue: 103(8), P. e37265 - e37265

Published: Feb. 23, 2024

Red blood cells (RBCs), traditionally recognized for their oxygen transport role, have garnered increasing attention significance as crucial contributors to the pathophysiology of diabetes mellitus. In this comprehensive review, we elucidate multifaceted roles RBCs both biomarkers and mediators in Amidst intricate interplay altered metabolic pathways diabetic milieu, manifest distinct alterations structure, function, lifespan. The chronic exposure hyperglycemia induces oxidative stress, leading modifications RBC physiology membrane integrity. These modifications, including glycation hemoglobin (HbA1c), establish invaluable assessing glycemic control over extended periods. Moreover, serve progression complications. Their involvement vascular dysfunction, hemorheological changes, inflammatory contributes significantly microangiopathy associated Exploring therapeutic implications, review addresses potential interventions targeting abnormalities ameliorate conclusion, comprehending nuanced mellitus offers promising avenues enhanced diagnostic precision, interventions, improved patient outcomes. This consolidates current understanding emphasizes imperative need further research harness full RBC-related insights realm

Language: Английский

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Red blood cell distribution width to albumin ratio associates with prevalence and long-term diabetes mellitus prognosis: an overview of NHANES 1999–2020 data

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: July 24, 2024

Background Erythrocyte dysfunction is a characteristic of diabetes mellitus (DM). However, erythrocyte-associated biomarkers do not adequately explain the high prevalence DM. Here, we describe red blood cell distribution width to albumin ratio (RAR) as novel inflammatory biomarker for evaluating an association with DM and prognosis all-cause mortality. Methods Data analyzed in this study were extracted from National Health Nutrition Examination Survey (NHANES) 1999−2020. A total 40,558 participants (non-DM DM) enrolled study; RAR quartiles calibrated at Q1 [2.02,2.82] mL/g, Q2 (2.82,3.05] Q3 (3.05,3.38] Q4 (3.38,12.08] mL/g. 8,482 patients followed (for median 84 months), whom 2,411 died 6,071 survived. The associated analyzed; age sex stratified analyze sensitivity long-term prognosis. Results Among non-DM ( n =30,404) =10,154) volunteers, was 8.23%, 15.20%, 23.92%, 36.39%. multivariable odds (OR) significant regarding DM, 1.68 (95% CI 1.42, 1.98). Considering foundation, OR 2.57 2.11, 3.13). percentages morbidity varied across dead =2,411) surviving =6,071) patients. Specifically, quartile mortality ratios 20.31%, 24.24%, 22.65%, 29.99% (P<0.0001). hazard (HR) 1.80 1.57, 2.05). HR 2.59 2.18, 3.09) after adjusting confounding factors. Sensitivity analysis revealed male be 2.27 1.95, 2.64), higher than females 1.56 1.31, 1.85). who 60 years or younger had 2.08 CI1.61, 2.70) compared those older years, 1.69 1.47, 1.94). optimized by restricted cubic spline (RCS) model; 3.22 determined inflection point inverse L-curve. >3.22 mL/g suffered shorter survival ≤3.22 values much regular width. Conclusions predictive value more accurate that RDW projecting prevalence, while RAR, risk factor, has prognostic power condition. Survival time found reduced increased aged ≤60 among female

Language: Английский

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Anemia and Its Connections to Inflammation in Older Adults: A Review

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(7), P. 2049 - 2049

Published: April 2, 2024

Anemia is a common hematological disorder that affects 12% of the community-dwelling population, 40% hospitalized patients, and 47% nursing home residents. Our understanding impact inflammation on iron metabolism erythropoiesis still lacking. In older adults, anemia can be divided into nutritional deficiency anemia, bleeding unexplained anemia. The last type might caused by reduced erythropoietin (EPO) activity, progressive EPO resistance bone marrow erythroid progenitors, chronic subclinical pro-inflammatory state. Overall, one-third patients with demonstrate deficiency, have state kidney disease, suffer from unknown etiology. Understanding anemia’s pathophysiology in people aged 65 over crucial because it contributes to frailty, falls, cognitive decline, decreased functional ability, higher mortality risk. Inflammation produces adverse effects cells system. These include (hypoferremia), production, elevated phagocytosis erythrocytes hepatic splenic macrophages. Additionally, causes enhanced eryptosis due oxidative stress circulation. Identifying mechanisms behind age-related essential for better preventing adults.

Language: Английский

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A detailed insight into the role of nanosized drug carriers for the management of diabetic wounds

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106688 - 106688

Published: Feb. 1, 2025

Language: Английский

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Chronobiological Changes in Biochemical Hemorrheological Parameters and Cytokine Levels in the Blood of Diabetic Patients on Hemodialysis: A Cross-Sectional Study

Kidney and Dialysis, Journal Year: 2025, Volume and Issue: 5(1), P. 9 - 9

Published: March 3, 2025

Introduction: Diabetes mellitus, a chronic disease characterized by hyperglycemia, is significant contributor to kidney disease, particularly in patients with diabetic nephropathy undergoing renal replacement therapy. Variations circadian rhythms can influence the progression of diseases and treatment outcomes. Aims: This observational study evaluated gender-based chronobiological changes biochemical, hemorheological factors, cytokines dialysis-dependent nephropathy. Materials Methods: A cross-sectional was conducted Barra do Garças, Brazil, involving 46 type 2 diabetes mellitus who were on regular hemodialysis. Participants divided into four groups for analysis according gender period day. Inclusion criteria included individuals periodic hemodialysis, receiving hemodialysis care at service, signing consent form. Patients an age under 18 years, 1, or autoimmune excluded. Blood samples collected assess melatonin, cortisol, biochemical parameters, such as IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10, IL-17. Results: Men exhibited higher urea, creatinine levels morning afternoon phases. At same time, women showed lower increased viscosity, decreased deformation rate afternoon. Additionally, IL-17 serum from women. Conclusion: These findings suggest that both timing should be taken account, when optimizing deeper understanding these factors could lead more personalized effective strategies, ultimately improving patient outcomes enhancing their quality life.

Language: Английский

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Anemias in endocrine diseases

Experimental and Clinical Gastroenterology, Journal Year: 2025, Volume and Issue: 9, P. 44 - 54

Published: March 6, 2025

Endocrine gland disorders increase the risk of developing anemia and are an independent cause their occurrence. Of all endocrine diseases, diabetes mellitus diabetic nephropathy, hypothyroidism, adrenal insufficiency, hypogonadism contribute most to development anemia. The pathophysiological basis for occurrence in these conditions is multifactorial requires further investigation. diseases lead microcytic, normocytic, macrocytic hypochromic, normochromic, hyperchromic anemias. resulting leads aggravation course underlying disease, thus closing vicious circle. Simultaneous complex treatment both pathology more successful correction

Language: Английский

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Association between the red blood cell distribution width-albumin ratio and cardiovascular diseases

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 9, 2025

Cardiovascular disease (CVD) is the major cause of death globally, ranking first in terms morbidity and mortality among non-communicable diseases. Red blood cell distribution width (RDW) albumin (ALB) possess potential clinical application values. Moreover, ratio two, namely RAR, might hold more advantages diagnosis. However, relationship between RAR CVD general population has not been studied yet. This represents a study encompassing 12,765 subjects. Logistic regression, Cox restricted cubic splines, mediation analysis, receiver operating characteristic curves were utilized to probe into association CVD, cardiovascular rate all-cause rate. A total participants enrolled this study, The mean age was 47.47 ± 16.33 years. regression revealed that positively correlated with CVD. Furthermore, COX also illustrated non-linearly associated both (all-cause mortality: p-non-linear = 0.0322; 0.0280). Additionally, ROC results indicated at various time points, exhibited stronger discriminatory capacity for compared HbA1c partially mediated Subgroup analysis interaction findings demonstrated hypertension race exerted significant influence on significantly linked an elevated risk higher level, greater Thus, could potentially be independent factor underscores crucial value discrimination management

Language: Английский

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