Inorganic Chemistry Communications, Journal Year: 2023, Volume and Issue: 158, P. 111535 - 111535
Published: Oct. 1, 2023
Language: Английский
Computational and Theoretical Chemistry, Journal Year: 2023, Volume and Issue: 1224, P. 114108 - 114108
Published: April 3, 2023
Language: Английский
Citations
12
The Chemical Record, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Abstract Palladium‐catalyzed carbonylative reactions, used as a tool for the insertion of carbonyl group into organic moieties, is synthetically useful transformation. Carbonylative Sonogashira coupling convenient approach synthesis α,β‐acetylenic ketones which are important class molecules in pharmaceutical and industrial fields. Development greener approaches environmentally benign catalytic systems put forward enormous opportunities this field moreover, these researches indicate formation heterocycles via carbonylation strategy, major highlight. Herein, we discuss progress achieved palladium‐catalyzed from 2013 to 2024 its future prospects.
Language: Английский
Citations
0
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 539, P. 216762 - 216762
Published: May 5, 2025
Language: Английский
Citations
0
Results in Chemistry, Journal Year: 2023, Volume and Issue: 7, P. 101283 - 101283
Published: Dec. 23, 2023
The ever-increasing environmental pollution and its health concerns appeal replacement of conventional organic synthesis with green synthetic methodology. This review presented detailed overview the pharmacological important heterocycles in last five years. reactions discussed herein characterized by high atomic economy, excellent isolated yield, occur relatively short time, use solvents at mild reaction conditions. It provided a discussion about application multicomponent recyclable magnetic nanocatalysts heterocyclic scaffold. importance principles have been highlighted. Similarly, preparation, recovery recyclability nanocatalyst composites were explained. dual advantage employing inexpensive biodegradable biopolymers as composite was emphasized. scope effectiveness designed methodologies well potential uses synthesized discussed. In addition, ecofriendly properties work up process also elaborated.
Language: Английский
Citations
9
Molecules, Journal Year: 2024, Volume and Issue: 29(6), P. 1406 - 1406
Published: March 21, 2024
SARS-CoV, an RNA virus, is contagious and displays a remarkable degree of adaptability, resulting in intricate disease presentations marked by frequent genetic mutations that can ultimately give rise to drug resistance. Targeting its viral replication cycle could be potential therapeutic option counter growth the human body leading severe infectious stage. The Mpro SARS-CoV-2 promising target for development as it crucial transcription replication. derivatives β-diketone coumarin have already been reported their antiviral and, thus, are considered scaffold current study computational design analogs targeting SARS-CoV-2. In our study, we used novel diketone-hinged against MPro develop broad-spectrum agent Through analysis pharmacokinetics docking studies, identified list top 10 compounds demonstrated effectiveness inhibiting virus. On basis analyses, 5 were synthesized characterized. thermodynamic stability KS82 KS94 was confirmed molecular dynamics, simulated system indicated inhibitory nature. Molecules further evaluated anti-viral using Vero E6 cells followed RT-PCR assay test compound most active with inhibit cells. These data indicate prevents attack virus emerges primary candidate properties.
Language: Английский
Citations
2
European Journal of Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 27(19)
Published: May 10, 2024
Abstract AcAc (β‐acetylacetonate) are among the first ligands ever to be studied. They form stable complexes with most metals. During 1960s, their sulfur derivatives were introduced, including AcSac (β‐thioketonate), SacSac (β‐dithioketonate) and SacNac (β‐thioketoiminate). These exhibit contrasting reactivity, stereochemical, magnetic spectral properties formed complexes. Sulfur ligand‐based at pinnacle in early 1970s, but fell into disuse, due lack of methodologies for obtaining them absence synthetic tools structural modification. As an effort promote study application these sulfur‐ligands; this review will address history, they bring metal centers potential applications.
Language: Английский
Citations
2
ChemistryOpen, Journal Year: 2024, Volume and Issue: 13(11)
Published: Aug. 8, 2024
Abstract The present study describes an eco‐friendly NBS‐assisted regioselective synthesis of new 5‐acylfunctionalized 2‐( 1H ‐pyrazol‐1‐yl)thiazoles by condensation 3,5‐dimethyl‐1 H ‐pyrazole‐1‐carbothioamide with unsymmetrical 1,3‐diketones under solvent‐free conditions. structural elucidation the newly synthesized compounds was accomplished using various spectroscopic techniques viz. FTIR, NMR and mass spectrometry. All were examined for their in vitro antimicrobial potential against both pathogenic gram positive negative bacterial fungal species as well anthelmintic activity Pheretima posthuma earthworms. results revealed that all tested 3 a–j showed excellent particularly S. aureus . It also observed e i (MIC=62.5 μg/mL ) greater potency E. coli , whereas a h ( MIC=50 62.5 μg/mL) demonstrated better P. aeruginosa compound exhibited superior pyogenus when compared to standard drug Ampicillin (MIC=100μg/mL). Compound j remarkable antifungal activities. To find out binding interactions target proteins pharmacokinetic parameters compounds, silico investigations involving molecular docking studies ADMET predictions performed.
Language: Английский
Citations
2
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(36), P. 19891 - 19903
Published: Sept. 3, 2024
Oat straw, a residue of
Language: Английский
Citations
2
Natural Product Communications, Journal Year: 2024, Volume and Issue: 19(9)
Published: Sept. 1, 2024
Objectives Immortelle has garnered global attention for its cosmetic, medicinal, and culinary applications worldwide. Apart from neryl acetate, α-pinene γ-curcumene as the most important components estimation of essential oil quality, in recent years a group β-diketones, known italidiones, appear significant quality parameters. However, it is unknown how weather conditions (temperature precipitation) influence their accumulation hydrosol, nor anti-inflammatory potential. Methods This study investigates chemical composition immortelle hydrosol over three successive (2019/20, 2020/21, 2021/22), by GC-FID GC-MS analysis. In silico molecular docking model with Vascular Adhesion Protein-1 (VAP-1) was used simulation potential well other β-diketones present hydrosol. Results During three-year trial, established that compounds such α-pinene, italicene were positively correlated temperature negatively precipitation, total italidiones. Moreover, trans-caryophyllene, γ-curcumene, ar-curcumene negative correlation temperature, slight positive precipitation. On side, content both italidiones strongly temperatures, which opposite oil. Additionally, findings indicated could bind human VAP-1 protein vicinity topiquinone block function. Conclusion Weather affect variations volatile some cases can changes olfactory characteristics, criteria prescribed standards, even biological activities. These results indicate immortelle, may be responsible activity.
Language: Английский
Citations
2
Results in Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 101860 - 101860
Published: Oct. 1, 2024
Language: Английский
Citations
2