Curcumin and its anti‐colorectal cancer potential: From mechanisms of action to autophagy

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(7), P. 3525 - 3551

Published: May 3, 2024

Abstract Colorectal cancer (CRC) development and progression, one of the most common cancers globally, is supported by specific mechanisms to escape cell death despite chemotherapy, including cellular autophagy. Autophagy an evolutionarily highly conserved degradation pathway involved in a variety processes, such as maintenance homeostasis clearance foreign bodies, its imbalance associated with many diseases. However, role autophagy CRC progression remains controversial, it has dual function, affecting either or survival, senescence tumor therapy. Indeed, numerous data have been presented that serves alternative apoptosis when latter ineffective apoptosis‐resistant cells, which why also referred programmed type II. Curcumin, active constituents Curcuma longa , great potential combat influencing various signaling pathways epigenetic regulation safe cost‐effective approach. This review discusses efficacy curcumin against vitro vivo, particularly modulation pathways. While clinical studies assessed prevention treatment, none specifically examined Nonetheless, we offer overview correlations support use this polyphenol prophylactic co‐therapeutic agent CRC.

Language: Английский

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A mechanistic insight into the anticancer potentials of resveratrol: Current perspectives

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(8), P. 3877 - 3898

Published: May 20, 2024

Abstract Resveratrol is a widely recognized polyphenolic phytochemical found in various plants and their fruits, such as peanuts, grapes, berry fruits. It renowned for its several health advantages. The well known anticancer properties, substantial amount of clinical evidence has also established promise chemotherapeutic agent. This study focuses on assessing the properties resveratrol gaining insight into underlying molecular mechanisms. evaluates biopharmaceutical, toxicological characteristics, utilization to determine suitability further development reliable Therefore, information about preclinical studies was collected from different electronic databases up‐to‐date (2018–2023). Findings this revealed that potent therapeutic benefits against cancers involving mechanisms, induction oxidative stress, cytotoxicity, inhibition cell migration invasion, autophagy, arresting S phase cycle, apoptotic, anti‐angiogenic, antiproliferative effects by regulating pathways including PI3K/AKT, p38/MAPK/ERK, NGFR‐AMPK‐mTOR, so on. However, compound poor oral bioavailability due reduced absorption; limitation overcome applying nanotechnology (nanoformulation resveratrol). Clinical application showed types cancer with no serious adverse effects. We suggest additional extensive check efficacy, safety, long‐term hazards. could involve larger number samples establish drug treatment cancer.

Language: Английский

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Changes in Lysine Methylation Contribute to the Cytotoxicity of Curcumin in Colon Cancer Cells

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 335 - 335

Published: Jan. 16, 2025

Epigenetic abnormalities play a critical role in colon carcinogenesis, making them promising target for therapeutic interventions. In this study, we demonstrated that curcumin reduces cancer cell survival and decrease lysine methylation was involved such an effect. This correlated with the downregulation of methyltransferases EZH2, MLL1, G9a, both wild-type p53 (wtp53) HCT116 cells mutant (mutp53) SW480 cells, as well SET7/9 specifically wtp53 cells. The effects induced by were more pronounced where it stronger apoptosis ferroptosis. Interestingly, also reduced mutp53 expression, suggesting could enhance efficacy other therapies, particularly overcoming drug resistance mechanisms associated mutp53. For instance, show sensitized to inhibition sinefungin, further supporting its potential combinatorial agent. However, although lesser extent, impaired HCT 116 null molecular pathways or factors, beyond p53, may be curcumin-induced cytotoxicity.

Language: Английский

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Metformin enhances anti-cancer properties of resveratrol in MCF-7 breast cancer cells via induction of apoptosis, autophagy and alteration in cell cycle distribution

Biochemical and Biophysical Research Communications, Journal Year: 2022, Volume and Issue: 644, P. 130 - 139

Published: Dec. 24, 2022

Language: Английский

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Co‐administration of curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(4), P. 1688 - 1702

Published: March 8, 2023

Abstract Natural plant phytochemicals are effective against different types of diseases, including cancer. Curcumin, a powerful herbal polyphenol, exerts inhibitory effects on cancer cell proliferation, angiogenesis, invasion, and metastasis through interaction with molecular targets. However, the clinical use curcumin is limited due to poor solubility in water metabolism liver intestine. The synergistic some such as resveratrol, quercetin, epigallocatechin‐3‐gallate, piperine can improve its efficacy treatment. present review specifically focuses anticancer mechanisms related co‐administration other phytochemicals, piperine. According evidence, phytochemical combinations exert suppressing reducing cellular inducing apoptosis cycle arrest. This also emphasizes significance co‐delivery vehicles‐based nanoparticles bioactive that could their bioavailability reduce systemic dose. Further high‐quality studies needed firmly establish combinations.

Language: Английский

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The Combination of Bioavailable Concentrations of Curcumin and Resveratrol Shapes Immune Responses While Retaining the Ability to Reduce Cancer Cell Survival

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 232 - 232

Published: Dec. 23, 2023

The polyphenols Curcumin (CUR) and Resveratrol (RES) are widely described for their antitumoral effects. However, low bioavailability is a drawback use in therapy. aim of this study was to explore whether CUR RES, used at bioavailable concentration, could modulate immune responses while retaining antitumor activity determine RES effects on the peripheral blood mononuclear cells (PBMCs) tumor growth inhibition be improved by combination. We demonstrate that low-dose combination reduced survival cancer cell lines but had no effect viability PBMCs. Although following + treatment T lymphocytes showed an enhanced activated state, counteracted increased IFN-γ expression induced polyphenol IL-10 production regulatory cells. On other hand, combined NK through up- downregulation activating inhibitory receptors CD68 levels monocytes/macrophages. Overall, our results indicate doses differentially shapes activity, support combinations anticancer therapy suggest its possible application as adjuvant cell-based immunotherapies.

Language: Английский

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Targeting STAT3 signaling pathway by curcumin and its analogues for breast cancer: A narrative review

Animal Models and Experimental Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract Background Breast cancer (BC) continues to be a significant global health issue, with rising number of cases requiring ongoing research and innovation in treatment strategies. Curcumin (CUR), natural compound derived from Curcuma longa, similar compounds have shown potential targeting the STAT3 signaling pathway, which plays crucial role BC progression. Aims The aim this study was investigate effects curcumin its analogues on based cellular molecular mechanisms. Materials & Methods literature search conducted for involved utilizing Scopus, ScienceDirect, PubMed, Google Scholar databases order identify pertinent articles. Results This narrative review explores CUR inhibiting activation, thereby suppressing proliferation cells, inducing apoptosis, metastasis. demonstrates that directly inhibits phosphorylation STAT3, preventing movement into nucleus ability bind DNA, hindering survival cells. also enhances effectiveness other therapeutic agents modulates tumor microenvironment by affecting tumor‐associated macrophages (TAMs). analogues, such as hydrazinocurcumin (HC), FLLL11, FLLL12, GO‐Y030, show improved bioavailability potency resulting reduced cell increased apoptosis. Conclusion hold promise effective adjuvant treatments pathway. These provide new insights mechanisms action enhance therapies.

Language: Английский

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Evaluation of the synergistic effects of curcumin-resveratrol co-loaded biogenic silica on colorectal cancer cells

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: June 11, 2024

Colorectal cancer (CRC) remains a significant global health concern, being the third most diagnosed in men and second women, with alarming mortality rates. Natural phytochemicals have gained prominence among various therapeutic avenues explored due to their diverse biological properties. Curcumin, extracted from turmeric, resveratrol, polyphenol found several plants, exhibited remarkable anticancer activities. However, limited solubility bioavailability hinder efficacy. To enhance of these compounds, nanomaterials work as effective carriers biogenic silica (BS) attracting major attention owing exceptional biocompatibility high specific surface area. In this study, we developed Curcumin-resveratrol-loaded BS (Cur-Res-BS) investigated effects on colorectal cell lines (HCT-116 Caco-2). Our results demonstrated concentration-dependent inhibition viability HCT-116 cells revealed complex interplay crucial proto-onco or tumor suppressor genes, such

Language: Английский

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Phytochemicals targeting lncRNAs: A novel direction for neuroprotection in neurological disorders

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114692 - 114692

Published: April 12, 2023

Language: Английский

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Co-delivery of curcumin and resveratrol by folic acid-conjugated poly(glycerol adipate) nanoparticles for enhanced synergistic anticancer effect against osteosarcoma

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105610 - 105610

Published: March 23, 2024

This study explored the co-delivery of curcumin (CUR) and resveratrol (RV) using folic acid-conjugated poly(glycerol adipate)-based nanoparticles (FPPC NPs) to enhance their synergistic anticancer effects against osteosarcoma. Based on toxicity experiments Saos-2 cells, optimal CUR:RV ratios were 1:2 1:3, which used for co-encapsulation. Increasing amount RV in co-loaded NPs did not affect properties nanocarriers, but predominantly increased loading capacity RV, especially at 1:3 ratio, by 1.8–2.0 times, mediated interaction. All demonstrated sustained release CUR with a burst presence accelerated initial from carriers. Furthermore, co-encapsulated maintained synergism greatly enhanced osteosarcoma least 1.8 times compared corresponding solutions through profound accumulation cells sub G1 phase late apoptosis. The internalization FPPC into via endocytosis was dose- time-dependent. offers proof-of-concept potential system tumor-targeted activity

Language: Английский

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