Screening for Neuroprotective and Rapid Antidepressant-like Effects of 20 Essential Oils

Biomedicines, Journal Year: 2023, Volume and Issue: 11(5), P. 1248 - 1248

Published: April 23, 2023

Depression is a serious psychiatric disorder with high prevalence, and the delayed onset of antidepressant effects remains limitation in treatment depression. This study aimed to screen essential oils that have potential for rapid-acting development. PC12 BV2 cells were used identify neuroprotective at doses 0.1 1 µg/mL. The resulting candidates treated intranasally (25 mg/kg) ICR mice, followed by tail suspension test (TST) an elevated plus maze (EPM) after 30 min. In each effective oil, five main compounds computationally analyzed, targeting glutamate receptor subunits. As result, 19 significantly abolished corticosterone (CORT)-induced cell death lactate dehydrogenase (LDH) leakage, 13 reduced lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-α) interleukin 6 (IL-6). From vivo experiments, six decreased immobility time mice TST, which Chrysanthemum morifolium Ramat. Myristica fragrans Houtt. also increased entries into open arms EPM. Four including atractylon, α-curcumene, α-farnesene, selina-4(14),7(11)-dien-8-one had affinity toward GluN1, GluN2B, Glu2A subunits surpassed reference compound ketamine. Overall, Atractylodes lancea (Thunb.) DC Ramat are worthy further research fast-acting antidepressants through interactions receptors, their (atractylon, selina-4(14),7(11)-dien-8-one) predicted underlie effect.

Language: Английский

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Phytochemical profile, assessment of antimicrobial and antioxidant properties of essential oils of Artemisia herba-alba Asso., and Artemisia dracunculus L.: Experimental and computational approaches

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1294, P. 136479 - 136479

Published: Aug. 23, 2023

Language: Английский

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Phytochemical Profiling, Antioxidant, Antimicrobial and Cholinesterase Inhibitory Effects of Essential Oils Isolated from the Leaves of Artemisia scoparia and Artemisia absinthium

Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(10), P. 1221 - 1221

Published: Oct. 1, 2022

The current studies were focused on the phytochemical profiling of two local wild Artemisia species, scoparia and absinthium leaves’ essential oils, extracted via hydro distillation method along with evaluation their antioxidant as well antimicrobial effects. constituents EOs identified using a combined gas chromatography-mass spectrometric (GC-MS) technique. A total 25 compounds in A. oil (EOAS) identified, 14 percentage abundance >1% tabulated, major being tocopherol derivatives (47.55%). nine (EOAA) enlisted (% age > 1%), majority oleic acid (41.45%). Strong effects pronounced by EOAS DPPH (IC50 = 285 ± 0.82 µg/mL) ABTS 295 0.32 free radical scavenging assays. Both remained potent inhibiting growth bacterial species; Escherichia coli (55−70%) Shigella flexneri (60−75%) however moderately effective against Bacillus subtilis Staphylococcus aureus. EOAA strongly inhibited tested fungal especially Aspergillus species (up to 70%). oils showed anti-cholinesterase potential both Acetylcholinesterase (AChE; IC50 30 0.04 µg/mL (EOAS), 32 0.05 Butyrylcholinesterase (BChE; 34 0.07 36 0.03 (EOAA). In conclusion, are promising antioxidant, anticholinergic agents different composition herein reported for first time.

Language: Английский

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Synecology of Lagoecia cuminoides L. in Italy and evaluation of functional compounds presence in its water or hydroalcoholic extracts

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Nov. 27, 2023

Lagoecia cuminoides L. is a very rare and threatened taxon in Italy, never studied before for its ecology potential use human consumption. Furthermore, few data are available on the biological activities of metabolites. A phytosociological study was carried out only two Italian sites, state conservation also evaluated according to IUCN (International Union Conservation Nature) protocol. The collected plant material used make types extracts: hot water infusion evaluate this as tea hydroalcoholic extraction it herbal liqueur preparation. presence functional compounds extracts were investigated by gas liquid chromatography coupled mass spectrometry techniques. Ten non volatiles identified extracts, most which derivatives quercetin. Thirty-five aerial part belonging chemical class terpenoids, among them β-farnesene, thymol, γ-terpinene p-cymene abundant. species characterized known their health effects applications consumption, being already decoction some countries Middle East. Thanks characteristic behaviour grow limiting pedoclimatic conditions can be potentially organic farms situated rural marginal areas.

Language: Английский

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A comprehensive review on engineered microbial production of farnesene for versatile applications

Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: 12(2), P. 112398 - 112398

Published: March 5, 2024

Language: Английский

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The effect mechanism of different natural spices on the formation of associated hazardous compounds in roasted chicken

Food Chemistry, Journal Year: 2025, Volume and Issue: 474, P. 143170 - 143170

Published: Jan. 31, 2025

Language: Английский

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Traditional uses, Phytochemistry, Pharmacology, and Toxicology of the GenusArtemisia L. (Asteraceae): A High-value Medicinal Plant

Current Topics in Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 24(4), P. 301 - 342

Published: Sept. 15, 2023

Abstract: Biologically active secondary metabolites, essential oils, and volatile compounds derived from medicinal aromatic plants play a crucial role in promoting human health. Within the large family Asteraceae, genus Artemisia consists of approximately 500 species. species have rich history traditional medicine worldwide, offering remedies for wide range ailments, such as malaria, jaundice, toothache, gastrointestinal problems, wounds, inflammatory diseases, diarrhoea, menstrual pains, skin disorders, headache, intestinal parasites. The therapeutic potential is multitude phytoconstituents, including terpenoids, phenols, flavonoids, coumarins, sesquiterpene lactones, lignans, alkaloids that serve pharmaceutical ingredients (API). remarkable antimalarial, antimicrobial, anthelmintic, antidiabetic, anti-inflammatory, anticancer, antispasmodic, antioxidative insecticidal properties possessed by are attributed to these APIs. Interestingly, several commercially utilized drugs, arglabin, artemisinin, artemether, artesunate, santonin, tarralin also been different However, despite vast potential, only limited number exploited commercially. Further, available literature on pharmacological uses lacks comprehensive reviews. Therefore, there an urgent need bridge existing knowledge gaps provide scientific foundation future research endeavours. It this context, present review aims account uses, phytochemistry, documented biological toxicity all offers useful insights practitioners researchers into underutilized their applications. This stimulate further exploration, experimentation collaboration fully realize augmenting health well-being.

Language: Английский

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Extraction methods, structural diversity and potential biological activities of Artemisia L. polysaccharides (APs): A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142802 - 142802

Published: April 1, 2025

Language: Английский

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Chemical Composition and Future Perspectives of Essential Oil Obtained from a Wild Population of Stachys germanica L. Distributed in the Balkan Mountains in Bulgaria

International Journal of Analytical Chemistry, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 11

Published: Oct. 31, 2023

Stachys germanica L. (Lamiaceae) is a plant associated with rich history in the traditional medicine of Iran, Turkey, and Serbia. However, researchers have not fully investigated pharmacological potential herb, scientific data on this species are limited. The aim current study was to evaluate chemical composition essential oil (EO) obtained from aerial parts S. growing wild Bulgaria perform comparative analysis EOs same other geographical regions. For evaluation profile isolated EO, gas chromatographic mass spectrometry performed. most abundant terpene class oxygenated monoterpenes, which accounted for 59.30% total EO composition. bicyclic monoterpene camphor, as compound class, identified major constituent accounting 52.96% Bulgarian quite different compared that It only one contain more than 50% camphor. In addition, contains significant amounts diterpene geranyl p-cymene (10.49%). This first describing L., our results reveal some future perspectives biological activity studied new therapeutic agent or natural remedy targeting medical conditions. has promising be used biopesticide repellent well, an environmentally friendly safer alternative standard pesticides.

Language: Английский

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Neutrophil Immunomodulatory Activity of (−)-Borneol, a Major Component of Essential Oils Extracted from Grindelia squarrosa

Molecules, Journal Year: 2022, Volume and Issue: 27(15), P. 4897 - 4897

Published: July 31, 2022

Grindelia squarrosa (Pursh) Dunal is used in traditional medicine for treating various diseases; however, little known about the immunomodulatory activity of essential oils from this plant. Thus, we isolated flowers (GEOFl) and leaves (GEOLv) G. evaluated chemical composition innate these oils. Compositional analysis revealed that main components were α-pinene (24.7 23.2% GEOFl GEOLv, respectively), limonene (10.0 14.7%), borneol (23.4 16.6%), p-cymen-8-ol (6.1 5.8%), β-pinene (4.0 3.8%), bornyl acetate (3.0 5.1%), trans-pinocarveol (4.2 3.7%), spathulenol 2.0%), myrtenol (2.5 1.7%), terpinolene (1.7 2.0%). Enantiomer showed α-pinene, β-pinene, present primarily as (−)-enantiomers (100% enantiomeric excess (ee) (−)-α-pinene (−)-borneol both GEOLv; 82 78% ee (−)-β-pinene GEOLv), while was (+)-enantiomer (94 96 GEOLv). activated human neutrophils, resulting increased [Ca2+]i (EC50 = 22.3 µg/mL 19.4 In addition, one major components, (−)-borneol, neutrophil 28.7 ± 2.6), whereas (+)-borneol inactive. Since treatments also if they able to down-regulate responses subsequent agonist activation found treatment with inhibited cells by N-formyl peptide receptor 1 (FPR1) fMLF FPR2 WKYMVM. Likewise, FPR-agonist-induced Ca2+ influx neutrophils. leaf flower oils, well fMLF-induced chemotaxis neutrophils (IC50 4.1 0.8 µg/mL, 5.0 1.6 5.8 1.4 µM, respectively). identified a novel modulator function.

Language: Английский

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