Polymers,
Journal Year:
2024,
Volume and Issue:
17(1), P. 18 - 18
Published: Dec. 25, 2024
The
grapevine
industry
is
confronted
with
challenges
such
as
plant
stress
from
environmental
factors
and
microbial
infections,
alongside
the
need
for
sustainable
waste
management
practices.
Natural
polymers
offer
promising
solutions
to
these
issues
due
their
biocompatibility,
biodegradability,
functional
versatility.
This
review
explores
dual
role
of
natural
in
enhancing
industry:
protective
agents
against
various
stressors
carriers
delivery
valuable
compounds
recovered
wastes.
We
examine
use
chitosan,
alginate,
cellulose
formulating
bio-based
coatings
treatments
that
bolster
resistance
abiotic
stress,
pathogens,
pests.
Additionally,
delves
into
innovative
utilization
residues,
including
skins,
seeds,
stems,
sources
polyphenols
other
bioactive
compounds.
These
can
be
efficiently
encapsulated
polymer
matrices
applications
agriculture,
food,
pharmaceuticals.
Key
topics
include
mechanisms
action,
benefits,
limitations
polymer-based
interventions,
well
case
studies
demonstrating
practical
implementation
vineyards.
also
addresses
future
research
directions,
emphasizing
integrated
approaches
enhance
sustainability
economic
viability
industry.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(4), P. 569 - 569
Published: April 22, 2024
Overcoming
the
limited
bioavailability
and
extensive
metabolism
of
effective
in
vitro
drugs
remains
a
challenge
that
limits
translation
promising
into
clinical
trials.
Resveratrol,
despite
its
well-reported
therapeutic
benefits,
is
not
metabolically
stable
thus
has
been
utilized
as
an
drug.
This
because
it
needs
to
be
consumed
large
amounts
overcome
burdens
conversion
less
metabolites.
Herein,
we
summarize
more
relevant
approaches
modify
resveratrol,
aiming
increase
biological
efficacy.
We
discuss
combination
therapies,
derivatization,
use
resveratrol
nanoparticles.
Interestingly,
with
established
chemotherapeutic
shown
effects
on
colon
cancer
(with
oxaliplatin),
liver
cisplatin,
5-FU),
gastric
doxorubicin).
On
other
hand,
derivatizing
including
hydroxylation,
amination,
amidation,
imidation,
methoxylation,
prenylation,
halogenation,
glycosylation,
oligomerization,
differentially
modifies
could
used
for
preferential
outcomes.
Moreover,
encapsulation
allows
trapping
within
different
forms
shells
targeted
therapy.
Depending
nanoparticle
used,
can
enhance
solubility
absorption,
increasing
These
include
polymers,
metals,
solid
lipids,
nanoparticles
have
preclinical
results,
adding
“hype”
research
resveratrol.
review
provides
platform
compare
allow
directed
better
treatment
options
Heliyon,
Journal Year:
2025,
Volume and Issue:
11(3), P. e41654 - e41654
Published: Jan. 8, 2025
The
importance
of
nanocomposites
constantly
attains
attention
because
their
unique
properties
all
across
the
fields
especially
in
medical
perspectives.
study
green-synthesized
has
grown
to
be
extremely
fascinating
field
research.
Nanocomposites
are
more
promising
than
mono-metallic
nanoparticles
they
exhibit
synergistic
effects.
This
review
encapsulates
current
development
formulation
plant-mediated
by
using
several
plant
species
and
impact
secondary
metabolites
on
biocompatible
functioning.
Phyto-synthesis
produces
diverse
nanomaterials
with
biocompatibility,
environment-friendliness,
vivo
actions,
characterized
varying
sizes,
shapes,
biochemical
nature.
process
is
advantageous
conventional
physical
chemical
procedures.
New
studies
have
been
conducted
determine
biomedical
efficacy
against
various
diseases.
Unfortunately,
there
inadequate
investigation
into
green-assisted
nanocomposites.
Incorporating
phytosynthesized
therapeutic
interventions
not
only
enhances
healing
processes
but
also
augments
host's
immune
defenses
infections.
highlights
phytosynthesis
applications,
including
antibacterial,
antidiabetic,
antiviral,
antioxidant,
antifungal,
anti-cancer,
other
as
well
toxicity.
explores
mechanistic
action
achieve
designated
tasks.
Biogenic
for
multimodal
imaging
potential
exchange
methods
materials
Well-designed
utilized
innovative
theranostic
agents
subsequent
objective
efficiently
diagnosing
treating
a
variety
human
disorders.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(21), P. 12893 - 12893
Published: Oct. 25, 2022
Ovarian
cancer
is
one
of
the
most
dangerous
gynecologic
cancers
worldwide,
showing
a
high
fatality
rate
and
recurrence
due
to
diagnosis
at
an
advanced
stage
disease
occurrence
chemoresistance,
which
weakens
therapeutic
effects
chemotherapeutic
treatments.
In
fact,
although
paclitaxel
platinum-based
drugs
(carboplatin
or
cisplatin)
are
widely
used
alone
in
combination
treat
ovarian
cancer,
chemoresistance
significantly
reduces
these
drugs.
Metformin
hypoglycemic
agent
that
commonly
for
treatment
type
2
diabetes
mellitus
non-alcoholic
fatty
liver
disease.
However,
this
drug
also
shows
anti-tumor
activity,
reducing
risk
chemoresistance.
This
review
analyzes
current
literature
regarding
role
metformin
investigates
what
currently
known
about
its
platinum
resistance
restore
sensitivity
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(8), P. 7422 - 7422
Published: April 18, 2023
Type
2
diabetes
(T2D)
affects
a
large
part
of
the
adult
population
and
impairs
its
quality
life.
Because
this,
natural
compounds
with
antioxidant,
anti-inflammatory
hypoglycemic
properties
have
been
used
as
adjuvants.
Among
these
compounds,
resveratrol
(RV)
stands
out,
polyphenol
that
has
studied
in
several
clinical
trials,
results
which
are
controversial.
We
conducted
randomized
trial
on
97
older
adults
T2D
to
evaluate
effect
RV
oxidative
stress
markers
sirtuin
1,
using
doses
1000
mg/day
(EG1000,
n
=
37)
500
(EG500,
32)
compared
placebo
(PG,
28).
Biochemical
markers,
1
levels
were
measured
at
baseline
after
six
months.
observed
statistically
significant
increase
(p
<
0.05)
total
antioxidant
capacity,
gap,
percentage
subjects
without
oxidant
EG1000.
In
PG,
we
lipoperoxides,
isoprostanes
C-reactive
protein
levels.
An
score
mild
moderate
was
too.
Our
findings
suggest
exerts
more
efficient
than
mg/day.
Phytotherapy Research,
Journal Year:
2023,
Volume and Issue:
37(7), P. 2995 - 3008
Published: March 3, 2023
Abstract
Resveratrol
(RES)
has
various
pharmacological
bioactivities
and
its
anticancer
effects
in
lung
cancer
have
been
proven.
However,
the
underlying
mechanisms
of
action
RES
remain
unclear.
This
study
focused
on
Nrf2‐mediated
antioxidant
systems
RES‐treated
cells.
A549
H1299
cells
were
treated
with
concentrations
at
different
times.
decreased
cell
viability,
inhibited
proliferation,
increased
number
senescent
apoptotic
a
concentration‐
time‐dependent
manner.
Moreover,
RES‐induced
arrest
G1
phase
was
accompanied
by
changes
proteins
(Bax,
Bcl‐2,
cleaved
caspase
3).
Furthermore,
induced
phenotype
along
senescence‐related
markers
(senescence‐associated
β‐galactosidase
activity,
p21,
p‐γH2AX).
More
importantly,
prolonged
exposure
time
concentration,
intracellular
reactive
oxygen
species
(ROS)
continuously
accumulated,
resulting
decrease
Nrf2
downstream
response
elements,
including
CAT,
HO‐1,
NQO1,
SOD1.
Meanwhile,
ROS
accumulation
apoptosis
reversed
N‐acetyl‐
l
‐cysteine
treatment.
Taken
together,
these
results
suggest
that
disturb
cellular
homeostasis
destroying
pool
to
increase
production.
Our
findings
provide
new
perspective
intervention
cancer.
