Dementia and Depression: Biological Connections with Amyloid β Protein DOI Open Access
Zuleide Maria Ignácio, Helamã Moraes dos Santos, Amanda Gollo Bertollo

et al.

Authorea (Authorea), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 16, 2023

Dementia is an umbrella term for a broad group of age-associated neurodegenerative diseases. It estimated that dementia affects 50 million people worldwide and Alzheimer’s disease (AD) responsible up to 75% cases. Small extracellular senile plaques composed filamentous aggregates amyloid β (Aβ) protein tend bind neuronal receptors, affecting cholinergic, serotonergic, dopaminergic, noradrenergic neurotransmission, leading neuroinflammation, among other pathophysiologic processes, subsequent death, followed by dementia. The cascade hypothesis points pathological process in the cleavage precursor (APP), resulting Aβ. There close relationship between pathologies lead depression. depression prevalent 90% individuals diagnosed with Parkinson’s disease, varying severity, 20 30% cases disease. hypothalamic pituitary adrenal (HPA) axis great intermediary pathophysiological mechanisms diseases This review discusses role Aβ depression, considering HPA axis, oxidative stress, signaling pathways, neurotransmission.

Language: Английский

The Impact of Sulforaphane on Sex-Specific Conditions and Hormone Balance: A Comprehensive Review DOI Creative Commons
Jed W. Fahey,

Mirran Raphaely

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 522 - 522

Published: Jan. 8, 2025

The health-promoting, preventive, protective, and therapeutic applications of the natural compound sulforaphane (SF) produced from its biogenic precursor in broccoli, glucoraphanin, are extremely well established. SF has been subject thousands studies over 125 clinical trials. many mechanisms action mammalian systems have extensively documented. is most potent naturally occurring inducer Keap1/Nrf2 pathway, which well-known for upregulation antioxidant detoxification activation pathways resulting inhibition inflammation. Much this regulation involves various hormonal axes body. However, influence on hormone-mediated health conditions remains unexplored recent scholarly reviews. This review aims to address gap by exploring these interactions, with a focus wellness issues specific both females males.

Language: Английский

Citations

1
Dementia and depression: Biological connections with amyloid β protein DOI Open Access
Helamã Moraes dos Santos, Amanda Gollo Bertollo, Maiqueli Eduarda Dama Mingoti

et al.

Basic & Clinical Pharmacology & Toxicology, Journal Year: 2024, Volume and Issue: 134(5), P. 563 - 573

Published: March 8, 2024

Dementia is an umbrella term for a broad group of age-associated neurodegenerative diseases. It estimated that dementia affects 50 million people worldwide and Alzheimer's disease (AD) responsible up to 75% cases. Small extracellular senile plaques composed filamentous aggregates amyloid β (Aβ) protein tend bind neuronal receptors, affecting cholinergic, serotonergic, dopaminergic noradrenergic neurotransmission, leading neuroinflammation, among other pathophysiologic processes subsequent death, followed by dementia. The cascade hypothesis points pathological process in the cleavage precursor (APP), resulting Aβ. There close relationship between pathologies lead depression. depression prevalent 90% individuals diagnosed with Parkinson's disease, varying severity, 20 30% cases disease. hypothalamic pituitary adrenal (HPA) axis great intermediary pathophysiological mechanisms diseases This review discusses role Aβ depression, considering HPA axis, oxidative stress, signalling pathways neurotransmission.

Language: Английский

Citations

8
The role of isothiocyanate-rich plants and supplements in neuropsychiatric disorders: a review and update DOI Creative Commons

Monica Ramakrishnan,

Jed W. Fahey, Andrew W. Zimmerman

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 30, 2024

Neuroinflammation in response to environmental stressors is an important common pathway a number of neurological and psychiatric disorders. Responses immune-mediated stress can lead epigenetic changes the development neuropsychiatric Isothiocyanates (ITC) have shown promise combating oxidative inflammation nervous system as well organ systems. While sulforaphane from broccoli most widely studied ITC for biomedical applications, their precursor glucosinolates are found many species cruciferous other vegetables including moringa. In this review, we examine both clinical pre-clinical studies on amelioration disorders (neurodevelopmental, neurodegenerative, other) 2018 present, documentation protocols several ongoing studies. During time, there been 16 (9 randomized controlled trials), which reported effect autism spectrum disorder schizophrenia. We also review over 80 preclinical examining treatment brain-related dysfunctions The evidence date reveals great potential treating these conditions with minimal toxicity. authors call well-designed trials further translation potent phytochemicals into therapeutic practice.

Language: Английский

Citations

6
Nrf2 Pathway in Huntington’s Disease (HD): What Is Its Role? DOI Open Access
Paolo Tucci, Roberta Lattanzi, Cinzia Severini

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(23), P. 15272 - 15272

Published: Dec. 3, 2022

Huntington’s disease (HD) is an autosomal dominant neurodegenerative that occurs worldwide. Despite some progress in understanding the onset of HD, drugs block or delay symptoms are still not available. In recent years, many treatments have been proposed; among them, nuclear transcriptional factor-2 (Nrf2) enhancer compounds proposed as potential therapeutic agents to treat HD. Nrf2 triggers endogenous antioxidant pathway activated different disorders. Probably, stimulation during either early phase before HD symptoms’ onset, could slow prevent striatum degeneration. this review, we present scientific literature supporting role and prophylactic compound.

Language: Английский

Citations

19
Endogenous extraction yielded high quality sulforaphane from broccoli sprouts unveils potent antioxidant and anti-Alzheimer's activities DOI Creative Commons

Shyam Kokkattunivarthil Uthaman,

Wan Seok Kang,

Juyoung Park

et al.

Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42673 - e42673

Published: Feb. 1, 2025

The extraction of sulforaphane (SFN) is challenging due to its instability and low water solubility, with existing methods often involving toxic solvents or yielding SFN. We optimized an endogenous protocol for high SFN content, characterized by HPLC LC-MS analyses. remained stable in refrigerated broccoli sprout extract powder (BSEP) over a month. BSEP showed four times higher oxygen radical absorbance capacity (ORAC) than the standard, indicating antioxidant capacity. It also reduced inflammatory responses down-regulating COX-2, IL-6, TNF-α gene expression LPS-induced RAW 264.7 macrophages. Additionally, exhibited neuroprotective properties amyloid-beta (1-42) (Aβ1-42)-induced Alzheimer's disease (AD) mice, enhancing memory learning retention maze passive avoidance tests. mitigated spatial cognitive impairment improved function Aβ1-42-induced memory-deficient mice. While did not alter acetylcholine (ACh) concentration, it inhibiting acetylcholinesterase (AChE) activity. content exceeding 200 mg/kg ameliorated neurobehavioral deficits protected brain from amyloid deposition, suggesting therapeutic potential AD treatment. propose eco-friendly form SFN-rich daily intake commercial therapeutics.

Language: Английский

Citations

0
Synthesis of ω-Methylsulfinyl- and ω-Methylsulfonylalkyl Glucosinolates DOI Creative Commons

Manolis Mavratzotis,

Stéphanie Cassel, Gina Rosalinda De Nicola

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 704 - 704

Published: Feb. 5, 2025

General pathways were devised to synthesize ω-methylsulfinyl- and ω-methylsulfonylalkyl glucosinolates, which represent an important class of structurally homogeneous plant specialized metabolites. The first approach was based on the selective S-oxidation ω-methylsulfanyl analogs previously obtained in our laboratory, producing corresponding sulfoxide or sulfone counterparts moderate yields. In alternative approach, prepared ω-nitroalkyl methylsulfide precursors selectively oxidized either sulfoxides sulfones. key-thiofunctionalized hydroximoyl chloride intermediates situ from sulfones using a nitronate chlorination strategy. A coupling reaction with 1-thio-β-d-glucopyranose directly applied, followed by O-sulfation intermediate thiohydroximates. final deprotection sugar moiety produced target compounds, including renowned glucoraphanin homologs, intended for further bioactivity investigations.

Language: Английский

Citations

0
The Plant Derived 3-3′-Diindolylmethane (DIM) Behaves as CB2 Receptor Agonist in Prostate Cancer Cellular Models DOI Open Access
Paolo Tucci, Iain Brown, Guy S. Bewick

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3620 - 3620

Published: Feb. 11, 2023

3-3'-Diindolylmethane (DIM) is a biologically active dimer derived from the endogenous conversion of indole-3-carbinol (I3C), naturally occurring glucosinolate found in many cruciferous vegetables (i.e., Brassicaceae). DIM was first pure androgen receptor antagonist isolated Brassicaceae family and has been recently investigated for its potential pharmacological use prostate cancer prevention treatment. Interestingly, there evidence that can also interact with cannabinoid receptors. In this context, by considering well-known involvement endocannabinoid system cancer, we have pharmacologically characterized properties on both CB1 CB2 receptors two human cell lines: PC3 (androgen-independent/androgen negative) LNCaP (androgen-dependent). line, able to activate potentially associated apoptotic pathways. On other hand, although no effects were observed. Our confirms ligand and, moreover, it anti-proliferative effect androgen-independent/androgen receptor-negative cells.

Language: Английский

Citations

7
Extraction, structural properties, and bioactivities of Moringa (Moringa oleifera Lam.) isothiocyanates: A review DOI
Qi Wu, Hejiang Zhou, Jun Sheng

et al.

Food Bioscience, Journal Year: 2023, Volume and Issue: 57, P. 103447 - 103447

Published: Dec. 9, 2023

Language: Английский

Citations

5
Peculiarities of the clinical picture and diagnosis of dirofilariasis in the maxillofacial area: a series of cases from practice DOI Creative Commons
К А Бунятян,

Yu. V. Khotimska,

І.В. Ковач

et al.

Medicni perspektivi, Journal Year: 2024, Volume and Issue: 29(1), P. 207 - 213

Published: April 1, 2024

Dirofilariasis is a helminthiasis that occurs in carnivorous animals (dogs, cats, foxes, wolves, etc.) and less often humans, although according to some authors it believed the number of infected approximately corresponds people. maxillofacial area not widespread condition, its cases are described short series, therefore, aim this work share our own experience managing patients with rare condition.The presents management 14 dirofilariasis lesions area, them there 3 men 11 women aged 29 54. Most sought help late autumn, winter spring periods only 2 people summer period. All were examined by dentist, an ultrasound examination formation was performed. According clinical manifestations, disease began acutely nine had picture inflamed atheroma (2 – zygomatic 1 parotid, infraorbital temporal nasal bridge). operated on tumor-like formations dense membranes removed, inside which one live nematode 11-18 cm long found. In observations, fragments dead, partially lysed nematodes removed from oral cavity, capsules imitated migrating granuloma. location 5 dirofilaria located subcutaneous fatty tissue, submucosal layer gums fused periosteum upper jaw, submucous lower fibers temporalis muscle buccal muscle. each case, localization close places accumulation adipose tissue or large blood vessels. postoperative period complex therapy prescribed, including symptomatic anti-inflammatory desensitizing agents, consultation infectionist recommended. Thus, most affects areas face vessels tissue. connection prevalence dirofilariosis humans predominant parasitic infection dentists, ophthalmologists otolaryngologists need be familiar pathology show definite vigilance. Treatment should carried out comprehensively, together parasitologists, surgical excision lesion appropriate drug therapy.

Language: Английский

Citations

0
Dementia and Depression: Biological Connections with Amyloid β Protein DOI Open Access
Zuleide Maria Ignácio, Helamã Moraes dos Santos, Amanda Gollo Bertollo

et al.

Authorea (Authorea), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 16, 2023

Dementia is an umbrella term for a broad group of age-associated neurodegenerative diseases. It estimated that dementia affects 50 million people worldwide and Alzheimer’s disease (AD) responsible up to 75% cases. Small extracellular senile plaques composed filamentous aggregates amyloid β (Aβ) protein tend bind neuronal receptors, affecting cholinergic, serotonergic, dopaminergic, noradrenergic neurotransmission, leading neuroinflammation, among other pathophysiologic processes, subsequent death, followed by dementia. The cascade hypothesis points pathological process in the cleavage precursor (APP), resulting Aβ. There close relationship between pathologies lead depression. depression prevalent 90% individuals diagnosed with Parkinson’s disease, varying severity, 20 30% cases disease. hypothalamic pituitary adrenal (HPA) axis great intermediary pathophysiological mechanisms diseases This review discusses role Aβ depression, considering HPA axis, oxidative stress, signaling pathways, neurotransmission.

Language: Английский

Citations

0