Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(2), P. 299 - 299
Published: Feb. 14, 2023
Cancer
is
one
of
the
major
healthcare
challenges
across
globe.
Several
anticancer
drugs
are
available
on
market
but
they
either
lack
specificity
or
have
poor
safety,
severe
side
effects,
and
suffer
from
resistance.
So,
there
a
dire
need
to
develop
safer
target-specific
drugs.
More
than
85%
all
physiologically
active
pharmaceuticals
heterocycles
contain
at
least
heteroatom.
Nitrogen
constituting
most
common
heterocyclic
framework.
In
this
study,
we
compiled
FDA
approved
with
nitrogen
atoms
their
pharmacological
properties.
Moreover,
reported
containing
heterocycles,
including
pyrimidine,
quinolone,
carbazole,
pyridine,
imidazole,
benzimidazole,
triazole,
β-lactam,
indole,
pyrazole,
quinazoline,
quinoxaline,
isatin,
pyrrolo-benzodiazepines,
pyrido[2,3-d]pyrimidines,
which
used
in
treatment
different
types
cancer,
concurrently
covering
biochemical
mechanisms
action
cellular
targets.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: April 15, 2024
Abstract
Cancer
is
a
major
public
health
problem
worldwide
with
more
than
an
estimated
19.3
million
new
cases
in
2020.
The
occurrence
rises
dramatically
age,
and
the
overall
risk
accumulation
combined
tendency
for
cellular
repair
mechanisms
to
be
less
effective
older
individuals.
Conventional
cancer
treatments,
such
as
radiotherapy,
surgery,
chemotherapy,
have
been
used
decades
combat
cancer.
However,
emergence
of
novel
fields
research
has
led
exploration
innovative
treatment
approaches
focused
on
immunotherapy,
epigenetic
therapy,
targeted
multi-omics,
also
multi-target
therapy.
hypothesis
was
based
that
drugs
designed
act
against
individual
targets
cannot
usually
battle
multigenic
diseases
like
Multi-target
therapies,
either
combination
or
sequential
order,
recommended
acquired
intrinsic
resistance
anti-cancer
treatments.
Several
studies
multi-targeting
treatments
due
their
advantages
include;
overcoming
clonal
heterogeneity,
lower
multi-drug
(MDR),
decreased
drug
toxicity,
thereby
side
effects.
In
this
study,
we'll
discuss
about
drugs,
benefits
improving
recent
advances
field
multi-targeted
drugs.
Also,
we
will
study
performed
clinical
trials
using
therapeutic
agents
treatment.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: March 23, 2024
Abstract
A
series
of
novel
1,2,3-triazole
and
chiral
Schiff
base
hybrids
2
–
6
were
synthesized
by
condensation
reaction
from
pre-prepared
parent
component
the
(1,2,3-triazole
1)
primary
amines
their
chemical
structure
confirmed
using
NMR
FTIR
spectroscopies,
CHN
elemental
analysis.
Compounds
1
evaluated
for
anticancer
activity
against
two
cancer
PC3
(prostate)
A375
(skin)
MRC-5
(healthy)
cell
lines
Almar
Blue
assay
method.
The
compounds
exhibited
significant
cytotoxicity
tested
lines.
Among
3
showed
very
good
inhibition
low
toxicity
healthy
All
high
binding
affinity
Androgen
receptor
modulators
(PDB
ID:
5t8e)
Human
MIA
1i1j)
inhibitors
compared
to
reference
drug
(cisplatin).
Structure
relationships
(SARs)
is
in
agreement
with
DFT
molecular
docking
studies.
desirable
physicochemical
properties
likeness.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(8), P. 2044 - 2044
Published: July 29, 2023
Ferrocene
has
been
the
most
used
organometallic
moiety
introduced
in
organic
and
bioinorganic
drugs
to
cure
cancers
various
other
diseases.
Following
several
pioneering
studies,
two
real
breakthroughs
occurred
1996
1997.
In
1996,
Jaouen
et
al.
reported
ferrocifens,
ferrocene
analogs
of
tamoxifen,
chemotherapeutic
for
hormone-dependent
breast
cancer.
Several
ferrocifens
are
now
preclinical
evaluation.
Independently,
1997,
ferroquine,
an
analog
antimalarial
drug
chloroquine
upon
introduction
a
ferrocenyl
substituent
carbon
chain,
was
by
Biot-Brocard
group
found
be
active
against
both
chloroquine-sensitive
chloroquine-resistant
strains
Plasmodium
falciparum.
Ferroquine,
combination
with
artefenomel,
completed
phase
IIb
clinical
evaluation
2019.
More
than
1000
studies
have
published
on
ferrocenyl-containing
pharmacophores
infectious
diseases,
including
parasitic,
bacterial,
fungal,
viral
infections,
but
relationship
between
structure
biological
activity
scarcely
demonstrated,
unlike
ferroquines.
majority
ferrocene-containing
drugs,
however,
production
reactive
oxygen
species
(ROS),
particular
OH.
radical,
produced
Fenton
catalysis,
plays
key
role
is
scrutinized
this
mini-review,
together
supramolecular
approach
utilizing
delivery
nanosystems,
such
as
micelles,
metal–organic
frameworks
(MOFs),
polymers,
dendrimers.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(10), P. 2277 - 2277
Published: May 12, 2024
Cancer
is
ranked
among
lethal
diseases
globally,
and
the
increasing
number
of
cancer
cases
deaths
results
from
limited
access
to
effective
therapeutics.
The
use
plant-based
medicine
has
been
gaining
interest
several
researchers.
Carvacrol
its
isomeric
compound,
thymol,
are
extracts
that
possess
biological
activities,
such
as
antimalarial,
anticancer,
antifungal,
antibacterial.
However,
their
efficacy
compromised
by
poor
bioavailability.
Thus,
medicinal
scientists
have
explored
synthesis
hybrid
compounds
containing
pharmacophores
enhance
therapeutic
improve
Hence,
this
review
a
comprehensive
report
on
carvacrol
isomer,
with
potent
anticancer
antibacterial
agents
reported
between
2020
2024.
Furthermore,
structural
activity
relationship
(SAR)
recommended
future
strategies
further
effects
will
be
discussed.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(19), P. 6368 - 6368
Published: Sept. 27, 2022
Pyridine,
1,3,4-thiadiazole,
and
1,3-thiazole
derivatives
have
various
biological
activities,
such
as
antimicrobial,
analgesic,
anticonvulsant,
antitubercular,
well
other
anticipated
properties,
including
anticancer
activity.
The
starting
1-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-3-phenylthiourea
(2)
was
prepared
reacted
with
hydrazonoyl
halides
3a-h,
α-haloketones
5a-d,
3-chloropentane-2,4-dione
7a
ethyl
2-chloro-3-oxobutanoate
7b,
which
afforded
the
3-aryl-5-substituted
1,3,4-thiadiazoles
4a-h,
3-phenyl-4-arylthiazoles
6a-d
4-methyl-3-
phenyl-5-substituted
thiazoles
8a,b,
respectively.
structures
of
synthesized
products
were
confirmed
by
spectral
data.
All
compounds
also
showed
remarkable
activity
against
cell
line
human
colon
carcinoma
(HTC-116)
hepatocellular
(HepG-2)
compared
Harmine
a
reference
under
in
vitro
condition.
1,3,4-Thiadiazole
4h
found
to
be
most
promising
an
excellent
performer
both
cancer
lines
(IC50
=
2.03
±
0.72
2.17
0.83
µM,
respectively),
better
than
drug
2.40
0.12
2.54
0.82
respectively).
In
order
check
binding
modes
above
thiadiazole
derivatives,
molecular
docking
studies
performed
that
established
site
EGFR
TK.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
15(1), P. 104 - 104
Published: Dec. 28, 2022
Selenium-containing
agents
are
more
and
considered
as
an
innovative
potential
treatment
option
for
cancer.
Light
is
shed
not
only
on
the
considerable
advancements
made
in
understanding
complex
biology
chemistry
related
to
selenium-containing
small
molecules
but
also
Se-nanoparticles.
Numerous
Se-containing
have
been
widely
investigated
recent
years
cancer
therapy
relation
tumour
development
dissemination,
drug
delivery,
multidrug
resistance
(MDR)
immune
system-related
(anti)cancer
effects.
Despite
numerous
efforts,
Se-agents
apart
from
selenocysteine
selenomethionine
yet
reached
clinical
trials
therapy.
The
purpose
of
this
review
provide
a
concise
critical
overview
current
state
art
highly
potent
target-specific
agents.
