Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 21, 2024
Comprehensive
Summary
Terpenoids
are
a
large
and
diverse
family
of
secondary
metabolites
that
have
gained
more
attention
from
chemists
pharmacologists
for
their
intriguing
skeletons
broad
biological
activities,
including
anti‐inflammatory,
antitumoral,
antimicrobial,
anti‐viral
effects.
Based
on
the
previous
reviews,
this
review
comprehensively
summarized
recent
advances
bioactive
terpenoids,
focusing
structural
features
promising
covering
literature
2020
to
2023.
In
review,
532
terpenoids
with
remarkable
chemical
architectures
properties
classified
into
sesquiterpenoids
(142),
diterpenoids
(129),
sesterterpenoids
(24),
triterpenoids
(52),
meroterpenoids
(185),
were
isolated
terrestrial
marine
resources.
This
would
provide
reference
researchers
rapidly
discover
interesting
further
study
as
drug
leads.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(11), P. e32239 - e32239
Published: May 31, 2024
This
study
proposes
a
novel
colorimetric
method
based
on
the
ultraviolet/visible
spectrophotometry-colorimetric
(UV/Vis-CM)
for
detecting
and
quantifying
total
triterpenoids
in
traditional
Chinese
medicine.
By
incorporating
colourants
2-hydroxy-5-methylbenzaldehyde
concentrated
sulfuric
acid,
triterpenoid
compounds
colour
development
became
more
sensitive,
detection
accuracy
was
significantly
improved.
acid
were
incorporated
1:3
volume
ratio
at
room
temperature
to
react
with
triterpenes
25
min,
an
ice
bath
5
then
detected
optimal
absorption
wavelength.
The
reliability
of
this
verified
by
comparison
high-performance
liquid
chromatography
four
other
methods.
Additionally,
approach
has
advantages
not
requiring
heating
during
operation,
high
sensitivity,
short
usage
time,
low
solvent
usage,
equipment
costs.
only
offers
reliable
medicine
but
also
rapid
tool
on-site
testing
large-scale
screening,
laying
foundation
modernisation
research,
quality
control,
drug
development.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(13), P. 3091 - 3091
Published: June 28, 2024
Oleanolic
acid
(OA)
is
a
vegetable
chemical
that
present
naturally
in
number
of
edible
and
medicinal
botanicals.
It
has
been
extensively
studied
by
chemists
scientific
researchers
due
to
its
biological
activity
against
wide
range
diseases.
A
significant
have
synthesized
variety
analogues
OA
modifying
structure
with
the
intention
creating
more
potent
agents
improving
pharmaceutical
properties.
In
recent
years,
enzymatic
techniques
employed
investigate
modify
OA.
This
review
presents
advancements
medical
chemistry
for
structural
modification
OA,
special
focus
on
biotransformation,
semi-synthesis
relationship
between
modified
structures
their
biopharmaceutical
Molecules,
Journal Year:
2024,
Volume and Issue:
29(4), P. 814 - 814
Published: Feb. 9, 2024
Asteraceae
(Compositae),
commonly
known
as
the
sunflower
family,
is
one
of
largest
plant
families
in
world
and
includes
several
species
with
pharmacological
properties.
In
search
for
new
antiviral
candidates,
an
vitro
screening
against
dengue
virus
(DENV)
was
performed
on
a
series
dichloromethane
methanolic
extracts
prepared
from
six
species,
including
Acmella
bellidioides,
Campuloclinium
macrocephalum,
Grindelia
pulchella,
chiloensis,
Helenium
radiatum,
Viguiera
tuberosa,
along
pure
phytochemicals
isolated
Asteraceae:
mikanolide
(1),
eupatoriopicrin
(2),
eupahakonenin
B
(3),
minimolide
(4),
estafietin
(5),
2-oxo-8-deoxyligustrin
(6),
santhemoidin
C
(7),
euparin
(8),
jaceidin
(9),
nepetin
(10),
jaceosidin
(11),
eryodictiol
(12),
eupatorin
(13),
5-demethylsinensetin
(14).
Results
showed
that
C.
macrocephalum
H.
radiatum
G.
pulchella
were
highly
active
selective
DENV-2,
affording
EC50
values
0.11,
0.15,
1.80,
3.85
µg/mL,
respectively,
SIs
171.0,
18.8,
>17.36,
64.9,
respectively.
From
pool
tested,
compounds
6,
7,
8
stand
out
most
(EC50
=
3.7,
3.1,
6.8
µM,
respectively;
SI
5.9,
6.7,
>73.4,
respectively).
These
results
demonstrate
their
chemical
constituents
represent
valuable
sources
molecules.
Journal of Pharmacy and Pharmacology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 25, 2024
Abstract
Objectives
Ganoderma
lucidum
(GL)
is
a
white
rot
fungus
widely
used
for
its
pharmacological
properties
and
health
benefits.
GL
consists
of
several
biological
components,
including
polysaccharides,
sterols,
triterpenoids.
Triterpenoids
are
often
found
in
the
form
lanostane-type
triterpenoids
with
quadrilateral
carbon
structures.
Key
findings
The
study
revealed
that
have
diverse
can
be
categorized
based
on
their
functional
groups.
derived
from
shown
potential
medicinal
applications.
They
disrupt
cell
cycle
by
inhibiting
β-catenin
or
protein
kinase
C
activity,
leading
to
anti-cancer,
anti-inflammatory,
anti-diabetic
effects.
also
reduce
production
inflammatory
cytokines,
thus
mitigating
inflammation.
Additionally,
been
enhance
immune
system’s
defenses
against
various
conditions.
possess
antioxidant,
antiparasitic,
anti-hyperlipidemic,
antimicrobial
activities,
making
them
suitable
pharmaceutical
Furthermore,
believed
afford
radioprotection
DNA,
protecting
it
radiation
damage.
Summary
This
review
focuses
types
isolated
GL,
synthesis
pathways,
chemical
highlights
characteristics
emphasizing
significant
role
therapeutic
applications
benefits
both
humans
animals.
Drug Development and Industrial Pharmacy,
Journal Year:
2025,
Volume and Issue:
51(2), P. 102 - 110
Published: Jan. 4, 2025
Background
Tontelea
micrantha,
a
notable
plant
species,
has
garnered
interest
for
its
medicinal
properties,
including
anti-inflammatory,
antibacterial
and
antiviral
effects.
A
vaccine
Chikungunia
virus
is
still
under
evaluation
no
specific
drug
been
licensed
to
date.
Heliyon,
Journal Year:
2025,
Volume and Issue:
11(4), P. e42595 - e42595
Published: Feb. 1, 2025
Despite
the
significant
fatality
rates
associated
with
Nipah
virus
(NiV)
outbreaks
in
South
Asia,
including
Bangladesh,
and
India,
till
today,
there
is
no
approved
medications
to
treat
it.
In
this
context,
small
molecules
propolis
were
computationally
screened
through
pharmacokinetic
toxicity
studies
followed
by
molecular
docking
dynamics
simulation
glycoprotein
(NiV-G
protein)
assess
their
anti-Nipah
potential.
A
thorough
literature
analysis
was
performed
identify
antiviral
compounds
from
a
pool
of
84
experimental
articles.
Following
ADMET
analysis,
27
out
34
docked
against
NiV-G
compared
control
ligand,
ribavirin,
which
an
investigational
drug
Nipah.
The
revealed
that
bauer-7-en-3β-yl
acetate
(BA)
moronic
acid
(MA)
bound
more
strongly
active
site
than
ribavirin
other
ligands.
Investigation
root-mean-square
deviation
(RMSD),
root
mean
square
fluctuations
(RMSF),
radius
gyration
(Rg),
solvent
accessible
surface
area
(SASA),
(MolSA),
binding
free
energy
(MM-PBSA),
complexity
hydrogen
bonds
(HBs),
secondary
structure
ligand-target
interactions
for
100
ns
(MD)
study
further
supported
complex's
stability
compactness.
Therefore,
silico
interaction
reports
both
may
be
possible
candidates
infection.
Objectives:
Evaluate
the
effectiveness
of
watermelon
rind
ethanolic
extract
in
reducing
blood
glucose
levels
glucose-induced
male
albino
mice
and
examine
potential
adverse
effects
impact
different
concentrations.
Methods:
This
vivo
study
was
conducted
at
Adventist
Medical
Center
College
Pharmacy
Department
Laboratory
involved
42
that
were
given
standard
care.
The
rinds
processed
into
a
powder,
extracted
using
maceration
refined
with
rotary
evaporator.
potency
antidiabetic
properties
Citrullus
lanatus
evaluated
by
observing
sugar
level
after
inducing
glucose.
divided
seven
groups,
each
receiving
varying
dosages
specific
extract.
samples
collected
cutting
small
portion
mouse
tail.
A
device
called
glucometer
utilized
to
monitor
level.
ANCOVA
then
for
analysis
data.
Results:
Univariate
showed
baseline
weight
did
not
significantly
affect
results,
but
treatment
significant
(p
<.01)
large
effect
size
(η2
=
.860).
Higher
doses
both
metformin
resulted
notable
loss.
reduction
observed,
especially
175
mg/kg
extract,
where
decreased
from
131
mg/dL
85.75
mg/dL.
rejected
null
hypothesis,
confirming
extract's
efficacy
lowering
levels.
Conclusion:
(Citrullus
lanatus)
could
potentially
be
used
as
against
diabetes.
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(5), P. 712 - 712
Published: May 12, 2025
‘Blood
stasis’
(syndrome)
(BSS)
is
a
fundamental
concept
in
Traditional
Chinese
Medicine
(TCM),
where
it
known
as
Xue
Yu
(血瘀).
Similar
concepts
exist
Korean
(‘Eohyul’)
and
Japanese
Kampo
medicine
(Oketsu).
Blood
stasis
considered
to
underpin
large
variety
of
inflammatory
diseases,
though
an
exact
equivalent
Western
systems
yet
be
described.
Some
time
ago
we
discovered
that
blood
can
clot
into
anomalous
amyloid
form,
creating
what
have
referred
fibrinaloid
microclots.
These
microclots
occur
great
many
chronic,
diseases
are
comparatively
resistant
fibrinolysis,
thus
the
ability
block
microcapillaries
hence
lower
oxygen
transfer
tissues,
with
multiple
pathological
consequences.
We
here
develop
idea
precisely
relate
to,
largely
mechanistically
responsible
for,
traditional
(a
term
also
used
by
Virchow).
First,
associated
all
stasis.
Secondly,
blocking
red
cell
transport,
provide
simple
mechanistic
explanation
for
physical
slowing
down
(‘stasis’)
flow.
Thirdly,
herbal
formulae
proposed
treat
these
especially
Fu
Zhu
its
derivatives,
anticoagulatory
anti-inflammatory,
consistent
they
actually
helping
levels
microclots,
plausibly
part
catalysis
polymerization
fibrinogen
form.
rehearse
some
actions
constituent
herbs
specific
bioactive
molecules
contain.
Consequently,
such
formulations
(and
their
components),
which
little
science
medicine,
would
seem
offer
opportunity
novel,
safe,
useful
treatments
chronic
display
including
Myalgic
Encephalopathy/Chronic
Fatigue
Syndrome,
long
COVID,
even
ischemic
stroke.
