Recent
interest
in
preventing
the
development
of
osteoporosis
has
focused
on
regulation
redox
homeostasis.
However,
action
lycopene
(LYC),
a
strong
natural
antioxidant
com-pound,
osteoporotic
bone
loss
remains
largely
unknown.
Here,
we
show
that
administra-tion
LYC
to
OVX
rats
reduces
body
weight
gain,
improves
lipid
metabolism
and
preserves
quality.
In
addition,
treatment
inhibits
ROS
overgeneration
serum
marrow
rats,
BMSCs
upon
H2O2
stimulation,
leading
inhibiting
adipogenesis
pro-moting
osteogenesis
during
remodeling.
Mechanically,
may
improve
quality
via
an
increase
expressions
FoxO1
Runx2,
decrease
PPARγ
C/EBPα
BMSCs.
Collectively,
these
findings
suggest
attenuates
through
promoting
regula-tion
FoxO1/PPARγ
pathway
driven
by
oxidative
stress,
presenting
novel
strategy
for
os-teoporosis
management.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(17), P. 3821 - 3821
Published: Aug. 31, 2023
Lycopene
is
a
compound
of
colored
origin
that
shows
strong
antioxidant
activity.
The
positive
effect
lycopene
the
result
its
pleiotropic
effect.
ability
to
neutralize
free
radicals
via
one
foundations
pro-health
effect,
including
inhibit
development
many
civilization
diseases.
Therefore,
this
study
focuses
on
importance
in
inhibiting
diseases
such
as
cardiovascular
diseases,
within
nervous
system,
diabetes,
liver
and
ulcerative
colitis.
According
research
mentioned,
supplementation
has
significant
promise
for
treatment
illnesses
marked
by
chronic
inflammation
oxidative
stress.
However,
majority
supporting
data
lycopene′s
health
benefits
comes
from
experimental
research,
whereas
evidence
clinical
studies
both
scarcer
less
certain
any
benefits.
Research
humans
still
required
establish
effectiveness.
Journal of Nutrition and Metabolism,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Lycopene
is
a
naturally
occurring
carotenoid
predominantly
found
in
tomatoes
and
tomato‐based
products.
Like
other
phytochemicals,
it
exhibits
health
beneficial
biological
activities
that
can
be
exploited
when
used
as
dietary
supplement.
In
vitro
vivo
,
lycopene
has
been
demonstrated
to
mitigate
oxidative
stress‐induced
metabolic
dysfunctions
diseases
including
inflammation,
obesity,
diabetes
mellitus.
shown
alleviate
affect
the
bone,
eye,
kidney,
liver,
lungs,
heart,
nervous
system.
This
review
presents
state
of
art
regarding
lycopene’s
benefits
its
potential
applications
system
delivery.
Furthermore,
protective
effects
against
toxins,
safety
use,
possible
toxicity
are
explored.
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(26), P. 14956 - 14966
Published: May 31, 2024
Atrazine
(ATR)
is
a
widely
used
herbicide
worldwide
that
can
cause
kidney
damage
in
humans
and
animals
by
accumulation
water
soil.
Lycopene
(LYC),
carotenoid
with
numerous
biological
activities,
plays
an
important
role
protection
due
to
its
potent
antioxidant
anti-inflammatory
effects.
The
current
study
sought
investigate
the
of
interactions
between
mtDNA
cGAS-STING
signaling
pathway
LYC
mitigating
PANoptosis
inflammation
kidneys
induced
ATR
exposure.
In
our
research,
350
mice
were
orally
administered
(5
mg/kg
BW/day)
(50
or
200
for
21
days.
Our
results
reveal
exposure
induces
decrease
stability,
resulting
release
into
cytoplasm
through
mPTP
pore
BAX
mobilization
pathway,
thereby
inducing
renal
inflammation.
inhibit
above
changes
caused
ATR.
conclusion,
inhibited
exposure-induced
histopathological
changes,
PANoptosis,
inhibiting
pathway.
demonstrate
positive
ATR-induced
injury
provide
new
therapeutic
target
treating
diseases
clinic.
Lycopene
is
a
compound
of
colored
origin
that
shows
strong
antioxidant
activity.
The
ability
to
neutralize
free
radicals
by
lycopene
the
basis
its
pro-health
effect,
including
inhibit
development
many
civilization
diseases.
Therefore,
this
study
focuses
on
importance
effect
in
inhibiting
such
diseases
as
cardiovascular
diseases,
etiology
etiology,
within
nervous
system.
Nutrition Research Reviews,
Journal Year:
2023,
Volume and Issue:
unknown, P. 1 - 17
Published: Dec. 18, 2023
Abstract
The
goal
of
this
narrative
review
is
to
summarise
the
current
knowledge
and
limitations
related
anti-inflammatory
effects
tomato,
tomato-derived
products
lycopene
in
context
metabolic
inflammation
associated
cardiometabolic
diseases.
potential
tomato
product
supplementation
supported
by
animal
vitro
studies.
In
addition,
intervention
studies
provide
arguments
favour
a
limitation
inflammation.
This
also
case
for
observational
depicting
inverse
association
between
plasma
levels
Nevertheless,
data
are
mixed
concerning
effect
not
an
pure
humans.
From
epidemiological
mechanistic
studies,
aims
identify
gaps
that
remain
be
filled
improve
our
comprehension
contrasted
lycopene.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(10), P. 2735 - 2735
Published: Oct. 9, 2023
Researchers
are
actively
exploring
potential
bioactive
compounds
to
enhance
the
effectiveness
of
Lisuride
(Lis)
in
treating
Parkinson’s
disease
(PD)
over
long
term,
aiming
mitigate
serious
side
effects
associated
with
its
extended
use.
A
recent
study
found
that
combining
dietary
flavonoid
Tiliroside
(Til)
Lis
has
anti-Parkinson’s
benefits.
The
showed
significant
improvements
PD
symptoms
induced
by
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP)
when
Til
and
were
given
together,
based
on
various
behavioral
tests.
This
combined
treatment
significantly
improved
motor
function
protected
dopaminergic
neurons
rats
MPTP.
It
also
activated
important
molecular
pathways
related
cell
survival
apoptosis
control,
as
indicated
increased
pAkt/Akt
ratio.
together
B-cell
lymphoma
2
(Bcl-2),
decreased
caspase
3
activity,
prevented
brain
decay.
Co-administration
reduced
tumor
necrosis
factor
alpha
(TNF-α)
Interleukin-1
(IL-1).
Antioxidant
markers
such
superoxide
dismutase
(SOD),
catalase,
glutathione
compared
MPTP-induced
control
group.
shows
using
effectively
treats
rats,
yielding
results
comparable
an
8
mg/kg
dose
levodopa,
highlighting
their
promising
treatments.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(10), P. 1443 - 1443
Published: May 10, 2024
Recent
interest
in
preventing
the
development
of
osteoporosis
has
focused
on
regulation
redox
homeostasis.
However,
action
lycopene
(LYC),
a
strong
natural
antioxidant
compound,
osteoporotic
bone
loss
remains
largely
unknown.
Here,
we
show
that
oral
administration
LYC
to
OVX
rats
for
12
weeks
reduced
body
weight
gain,
improved
lipid
metabolism,
and
preserved
quality.
In
addition,
treatment
inhibited
ROS
overgeneration
serum
marrow
rats,
BMSCs
upon
H2O2
stimulation,
leading
inhibiting
adipogenesis
promoting
osteogenesis
during
remodeling.
At
molecular
level,
quality
via
an
increase
expressions
FoxO1
Runx2
decrease
PPARγ
C/EBPα
BMSCs.
Collectively,
these
findings
suggest
attenuates
through
FoxO1/PPARγ
pathway
driven
by
oxidative
stress,
presenting
novel
strategy
management.
