Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(9), P. 1294 - 1294
Published: Sept. 13, 2023
This Special Issue presented recent progress on natural products that serve as drug candidates for redox-related human diseases [...]
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 13874 - 13874
Published: Sept. 9, 2023
Phenolic compounds or polyphenols are among the most common of secondary metabolism in plants. Their biosynthesis is characteristic all plant cells and carried out with participation shikimate acetate-malonate pathways. In this case, various structures formed, such as phenylpropanoids, flavonoids, oligomeric polymeric phenolic nature. number already exceeds 10,000. The diversity phenolics affects their biological activity functional role. Most representatives characterized by interaction reactive oxygen species, which manifests itself not only plants but also human body, where they enter through food chains. Having a high activity, successfully used medicines nutritional supplements for health population. accumulation depend on many factors, including physiological-biochemical, molecular-genetic, environmental factors. review, we present latest literature data structure classes compounds, antioxidant biosynthesis, molecular genetic aspects (genes transfactors). Since grow significant changes planet, response to action abiotic factors (light, UV radiation, temperature, heavy metals) at level composition these metabolites, well metabolic regulation, considered. Information given about important necessary components nutrition pharmaceutically valuable substances Proposals promising areas research development field presented.
Language: Английский
Citations
123
Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 967 - 967
Published: April 20, 2023
Inflammatory bowel disease (IBD) is a long-term, progressive, and recurrent intestinal inflammatory disorder. The pathogenic mechanisms of IBD are multifaceted associated with oxidative stress, unbalanced gut microbiota, aberrant immune response. Indeed, stress can affect the progression development by regulating homeostasis microbiota Therefore, redox-targeted therapy promising treatment option for IBD. Recent evidence has verified that Chinese herbal medicine (CHM)-derived polyphenols, natural antioxidants, able to maintain redox equilibrium in tract prevent abnormal radical responses. Here, we provide comprehensive perspective implementing antioxidants as potential candidate medications. In addition, demonstrate novel technologies stratagems promoting antioxidative properties CHM-derived including delivery systems, chemical modifications, combination strategies.
Language: Английский
Citations
62
Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(10), P. 2845 - 2916
Published: July 13, 2024
Abstract Several efforts have been extensively accomplished for the amelioration of cancer treatments using different types new drugs and less invasives therapies in comparison with traditional therapeutic modalities, which are widely associated numerous drawbacks, such as drug resistance, non-selectivity high costs, restraining their clinical response. The application natural compounds prevention treatment cells has attracted significant attention from pharmaceuticals scientific communities over past decades. Although use nanotechnology therapy is still preliminary stages, nanotherapeutics demonstrated to decrease various limitations related compounds, physical/chemical instability, poor aqueous solubility, low bioavailability. Despite emerged a promise improve bioavailability there limited trials performed challenges required pre-clinical trials, production at an industrial level, assurance long-term stability, physiological barriers safety regulatory issues. This review highlights most recent advances nanocarriers secreted plants, bacteria, fungi, marine organisms, well role on cell signaling pathways anticancer treatments. Additionally, status main regarding loaded applications were also discussed. Graphical abstract
Language: Английский
Citations
20
Molecules, Journal Year: 2023, Volume and Issue: 28(9), P. 3669 - 3669
Published: April 23, 2023
Geraniol (GNL), a natural monoterpene, is found in many essential oils of fruits, vegetables, and herbs, including lavender, citronella, lemongrass, other medicinal aromatic plants. GNL commonly used by the cosmetic food industries has shown wide spectrum pharmacological activities anti-inflammatory, anticancer, antimicrobial, antioxidant, neuroprotective activities. It represents potential anti-inflammatory agent promising cancer chemopreventive agent, as it been to be effective against broad range cancers, colon, prostate, breast, lung, skin, kidney, liver, pancreatic cancer. Moreover, scavenges free radicals preserves activity antioxidant enzymes. In addition, induces apoptosis cell cycle arrest, modulates multiple molecular targets, p53 STAT3, activates caspases, inflammation via transcriptional regulation. present study, different modes action are described for GNL’s inflammatory diseases. This compound protects various enzymes, such catalase, glutathione-S-transferase, glutathione peroxidase. Experiments using allergic encephalomyelitis, diabetes, asthma, carcinogenesis models showed that treatment had beneficial effects with low toxicity. animal tumor lines, but there have not any clinical studies carried out it. The aim review provide updated data on inflammation, enhance our understanding involved pathways, possible use therapeutic purposes inflammation-related
Language: Английский
Citations
30
BioNanoScience, Journal Year: 2024, Volume and Issue: 14(4), P. 4219 - 4237
Published: Jan. 10, 2024
Language: Английский
Citations
11
Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(8), P. 3877 - 3898
Published: May 20, 2024
Abstract Resveratrol is a widely recognized polyphenolic phytochemical found in various plants and their fruits, such as peanuts, grapes, berry fruits. It renowned for its several health advantages. The well known anticancer properties, substantial amount of clinical evidence has also established promise chemotherapeutic agent. This study focuses on assessing the properties resveratrol gaining insight into underlying molecular mechanisms. evaluates biopharmaceutical, toxicological characteristics, utilization to determine suitability further development reliable Therefore, information about preclinical studies was collected from different electronic databases up‐to‐date (2018–2023). Findings this revealed that potent therapeutic benefits against cancers involving mechanisms, induction oxidative stress, cytotoxicity, inhibition cell migration invasion, autophagy, arresting S phase cycle, apoptotic, anti‐angiogenic, antiproliferative effects by regulating pathways including PI3K/AKT, p38/MAPK/ERK, NGFR‐AMPK‐mTOR, so on. However, compound poor oral bioavailability due reduced absorption; limitation overcome applying nanotechnology (nanoformulation resveratrol). Clinical application showed types cancer with no serious adverse effects. We suggest additional extensive check efficacy, safety, long‐term hazards. could involve larger number samples establish drug treatment cancer.
Language: Английский
Citations
10
Current Opinion in Chemical Biology, Journal Year: 2023, Volume and Issue: 75, P. 102330 - 102330
Published: May 29, 2023
Language: Английский
Citations
21
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 256, P. 128501 - 128501
Published: Nov. 29, 2023
Language: Английский
Citations
17
Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 482 - 482
Published: Feb. 21, 2024
Focal adhesion plaques (FAPs) play an important role in the communication between cells and extracellular matrix (ECM) cells' migration. FAPs are macromolecular complexes made by different proteins which also interact with metalloproteinases (MMPs). Because of these fundamental properties, MMPs involved cancer invasion metastatic cascade. The most FAP formation activity (i) integrins, (ii) a complex intracellular (iii) cytoskeleton proteins. latter, together MMPs, filopodia invadopodia needed for cell movement ECM degradation. Due to their key migration invasion, components often upregulated thus potential targets therapy. Polyphenols, large group organic compounds found plant-based food beverages, reported have many beneficial healthy effects, including anticancer anti-inflammatory effects. In this review, we discuss growing evidence demonstrates that polyphenols can inhibit various pathways like PI3K/Akt, lower focal kinase (FAK) phosphorylation decrease invasiveness, leading overall antitumoral effect. Finally, here highlight could hold as adjunctive therapies conventional treatments due ability target mechanisms progression.
Language: Английский
Citations
6
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 972 - 972
Published: July 23, 2024
Cancer remains a highly lethal disease globally. The approach centered on REDOX-targeted mitochondrial therapy for cancer has displayed notable benefits. Plant polyphenols exhibit strong REDOX and anticancer properties, particularly by affecting function, yet their structural instability low bioavailability hinder utility. To overcome this challenge, researchers have utilized the inherent physical chemical characteristics of derivatives to develop innovative nanomedicines targeting mitochondria. This review examines construction strategies properties various types polyphenol-based biological nanomedicine regulating mitochondria in recent years, such as polyphenol self-assembly, metal–phenol network, polyphenol–protein, polyphenol–hydrogel, polyphenol–chitosan, polyphenol–liposome. These polyphenolic incorporate enhanced features improved solubility, efficient photothermal conversion capability, regulation homeostasis, ion adsorption through diverse strategies. focus is how these promote ROS production mechanism inhibit cancer. Furthermore, it delves into benefits applications treatments, well challenges future research.
Language: Английский
Citations
4