Molecules,
Journal Year:
2025,
Volume and Issue:
30(3), P. 652 - 652
Published: Feb. 1, 2025
Cereals
are
among
the
foods
rich
in
myo-inositol
hexakisphosphate
(phytic
acid,
IP6),
lower
phosphates
(IPx),
a
wide
range
of
phenolic
compounds,
as
well
vitamins,
minerals,
oligosaccharides,
phytosterols
and
para-aminobenzoic
attributed
with
multiple
bioactivities,
particularly
associated
prevention
metabolic
syndrome
colon
cancer.
The
bran
fraction
wheat,
maize,
brown
rice
other
cereals
contains
high
levels
phytate,
free
total
phenolics,
endogenous
enzymes
such
amylases,
phytase,
xylanase,
β-glucanase
feruloyl
esterase,
whose
activities
can
be
increased
by
germination.
preliminary
steps
digestion
begin
oral
cavity
where
substrates
for
action
cereal
salivary
start
to
released
from
food
matrix.
IP6
phytate
complexes
arabinoxylans,
starch
protein
bodies
would
eventually
enhance
absorption
nutrients,
including
regulating
tight
junctions
and,
together
ferulic
acid
(FA),
maintain
cell
barrier
integrity
epithelial
antibacterial
immunity.
In
addition,
both
FA
exert
potent
complementary
antioxidant
effects,
while
IPx
generated
through
advanced
hydrolysis
microbial
phytases
may
affect
digestive
enzyme
activity
incretin
secretion,
resulting
modulated
insulin
glucagon
release
various
diabetic
complications.
Contrary
widespread
negative
attitudes
towards
this
review,
we
present
strategy
selecting
content,
esterase
endoxylanase
activities,
produce
value-added
health-promoting
foods.
compounds
and/or
generate
substantial
amounts
“enzymatically
inositol”
(EGI),
IP6,
myo-inositol,
that,
FA,
provide
enhanced
bioavailability
nutrients
synergistic
effects
not
previously
realised.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(8), P. 985 - 985
Published: Aug. 14, 2024
Gut
dysbiosis,
resulting
from
an
imbalance
in
the
gut
microbiome,
can
induce
excessive
production
of
reactive
oxygen
species
(ROS),
leading
to
inflammation,
DNA
damage,
activation
immune
system,
and
epigenetic
alterations
critical
genes
involved
metabolic
pathways.
dysbiosis-induced
inflammation
also
disrupt
barrier
integrity
increase
intestinal
permeability,
which
allows
gut-derived
toxic
products
enter
liver
systemic
circulation,
further
triggering
oxidative
stress,
associated
with
diseases.
However,
specific
metabolites,
such
as
short-chain
fatty
acids
(SCFAs),
lactate,
vitamins,
modulate
stress
system
through
mechanisms,
thereby
improving
function.
microbiota
diet-induced
diseases,
obesity,
insulin
resistance,
dyslipidemia,
hypertension,
transfer
next
generation,
involving
mechanisms.
In
this
review,
we
will
introduce
key
that,
along
dysbiosis
ROS,
are
engaged
developing
Finally,
discuss
potential
therapeutic
interventions
dietary
modifications,
prebiotics,
probiotics,
postbiotics,
fecal
transplantation,
may
reduce
syndrome
by
altering
alterations.
summary,
review
highlights
crucial
role
pathogenesis
a
particular
focus
on
(including
histone
methylomics,
RNA
interference)
that
prevent
or
improve
Microorganisms,
Journal Year:
2023,
Volume and Issue:
11(7), P. 1849 - 1849
Published: July 21, 2023
The
gut
microbiome
plays
a
critical
role
in
maintaining
overall
health
and
immune
function.
However,
dysbiosis,
an
imbalance
composition,
can
have
profound
effects
on
various
aspects
of
human
health,
including
susceptibility
to
viral
infections.
Despite
numerous
studies
investigating
the
influence
infections
microbiome,
impact
dysbiosis
infection
pathogenesis
remains
relatively
understudied.
clinical
variability
observed
SARS-CoV-2
seasonal
influenza
infections,
presence
natural
HIV
suppressors,
suggests
that
host-intrinsic
factors,
may
contribute
pathogenesis.
has
been
shown
host
system
by
regulating
intestinal
homeostasis
through
interactions
with
cells.
This
review
aims
enhance
our
understanding
how
perturb
mucosal
cells,
affecting
response
Specifically,
we
focus
exploring
between
gamma
delta
(γδ)
T
cells
microbes
context
inflammatory
examine
highlighting
disease
outcomes.
Furthermore,
discuss
emerging
evidence
potential
future
directions
for
modulation
therapy
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 14, 2024
Recent
studies
have
indicated
that
gut
microbiota-mediated
oxidative
stress
is
significantly
associated
with
intestinal
diseases
such
as
colorectal
cancer,
ulcerative
colitis,
and
Crohn’s
disease.
The
level
of
reactive
oxygen
species
(ROS)
has
been
reported
to
increase
when
the
microbiota
dysregulated,
especially
several
bacterial
metabolites
are
present.
Although
healthy
plays
a
vital
role
in
defending
against
excessive
stress,
disease
influenced
by
ROS,
this
process
controlled
immunological
responses,
DNA
damage,
inflammation.
In
review,
we
discuss
relationship
between
from
an
perspective.
addition,
also
provide
summary
most
recent
therapeutic
approaches
for
preventing
or
treating
modifying
microbiota.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Feb. 1, 2024
Abstract
Inflammatory
bowel
disease
(IBD)
is
closely
linked
to
the
homeostasis
of
intestinal
environment,
and
exosomes
can
be
used
treat
IBD
due
their
high
biocompatibility
ability
effectively
absorbed
by
tract.
However,
Ginseng-derived
nanoparticles
(GDNPs)
have
not
been
studied
in
this
context
mechanism
action
remains
unclear.
Here,
we
investigated
GDNPs
mediate
intercellular
communication
a
complex
inflammatory
microenvironment
order
IBD.
We
found
that
scavenge
reactive
oxygen
species
from
immune
cells
epithelial
cells,
inhibit
expression
pro-inflammatory
factors,
promote
proliferation
differentiation
stem
as
well
enhancing
diversity
flora.
significantly
stabilise
barrier
thereby
promoting
tissue
repair.
Overall,
proved
ameliorate
inflammation
oxidative
stress
vivo
vitro,
acting
on
TLR4/MAPK
p62/Keap1/Nrf2
pathways,
exerting
an
anti-inflammatory
antioxidant
effect.
mitigated
mice
reducing
factors
improving
environment.
This
study
offers
new
evidence
potential
therapeutic
effects
IBD,
providing
conceptual
ground
for
alternative
strategy.
Graphical
Archives of Pharmacal Research,
Journal Year:
2024,
Volume and Issue:
47(2), P. 146 - 164
Published: Jan. 15, 2024
Abstract
The
gut
microbiota
that
exists
in
the
human
gastrointestinal
tract
is
incredibly
important
for
maintenance
of
general
health
as
it
contributes
to
multiple
aspects
host
physiology.
Recent
research
has
revealed
a
dynamic
connection
between
and
central
nervous
system,
can
influence
neurodegenerative
diseases
(NDs).
Indeed,
imbalances
microbiota,
or
dysbiosis,
play
vital
role
pathogenesis
progression
diseases,
particularly
NDs.
Herbal
medicine
been
used
centuries
treat
including
These
compounds
help
relieve
symptoms
delay
NDs
by
improving
intestinal
barrier
function,
reducing
neuroinflammation,
modulating
neurotransmitter
production.
Notably,
herbal
mitigate
regulating
microbiota.
Therefore,
an
in-depth
understanding
potential
mechanisms
which
regulates
treatment
explain
from
novel
perspective
propose
therapeutic
strategies
In
this
review,
we
investigate
neuroprotective
effects
medicine,
focusing
on
its
ability
regulate
restore
homeostasis.
We
also
highlight
challenges
future
priorities
integration
modern
medicine.
As
global
population
ages,
access
information
becoming
increasingly
developing
effective
treatments
these
diseases.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(6), P. e27527 - e27527
Published: March 1, 2024
Ulcerative
colitis
is
a
common
type
of
inflammatory
bowel
disease
that
affects
millions
individuals
around
the
world.
Traditional
UC
treatment
has
focused
on
suppressing
immune
responses
rather
than
treating
underlying
causes
UC,
which
include
oxidative
stress,
inflammation,
and
microbiota
dysbiosis.
Diosmin
(DIO),
naturally
occurring
flavonoid,
possesses
antioxidant
anti-inflammatory
properties.
This
study
aimed
to
assess
efficacy
DIO
in
dextran-sulfate
sodium
(DSS)-induced
colitis,
investigate
some
its
mechanisms,
with
an
emphasis
Akkermansia
muciniphila
abundance,
markers,
intestinal
barrier
function.
C57BL/6
mice
were
given
4%
(w/v)
DSS
induce
colitis.
DSS-induced
administered
(100
200
mg/kg)
or
sulfasalazine
orally
for
7
days.
Every
day,
activity
index
(DAI)
was
determined
by
recording
body
weight,
diarrhea,
bloody
stool.
Changes
fecal
A.
colonic
MUC1
MUC2
expression,
as
well
stress
markers
all
assessed.
Histopathological
changes,
PIK3PR3
ZO-1
levels,
immunohistochemical
examinations
occludin
claudin-1,
investigated.
administration
resulted
dose-dependent
decrease
DAI,
increase
abundance
expression
while
decreasing
expression.
also
dramatically
reduced
inflammation
regulating
NF-κB
Nrf2
cascades,
restored
integrity
inhibiting
PIK3R3
inducing
ZO-1,
improved
occludin/claudin-1
gene
immunostaining.
provides
first
evidence
preserves
increases
However,
more
research
required
explore
impact
overall
composition
diversity
gut
microbiota.
Likewise,
it
will
be
important
fully
understand
molecular
mechanisms
maintains
function
potential
use
adjuvant
UC.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: May 21, 2024
Abstract
IBD
is
a
disorder
which
could
be
caused
by
oxidative
stress.
This
investigation
aims
to
determine
if
probiotics
and
postbiotics
can
control
stress
inflammation
compare
the
effectiveness
of
these
two
probiotic
postbiotic
mixtures
substances.
88
strains
Lactobacillus
Bifidobacterium
were
tested
for
antioxidant
activity.
Male
wild-type
C57BL/6
mice
divided
into
four
experimental
groups,
namely
high
fat
diet
(HFD)
+
PBS,
HFD
DSS,
DSS
10
9
cfu/ml
probiotics,
postbiotics.
The
phenotypical
indices
pathological
scores
assessed.
expression
genes
related
NF-kB
Nrf2
signaling
pathways
enzymes
associated
with
oxidant/anti-oxidant
activities,
proinflammatory/inflammatory
cytokines
In
contrast
groups
exposed
treated
mixture
alongside
displayed
alleviation
DSS-induced
adverse
effects
on
characteristics,
as
well
molecular
such
genes,
greater
emphasis
component.
accordance
findings
present
investigation,
it
inferred
that
even
in
using
high-fat
dietary
regimen
an
inducer
stress,
emergence
effectively
addressed
through
utilization
and,
more
specifically,
