Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 27, 2024
Language: Английский
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(2), P. 246 - 246
Published: Feb. 13, 2024
Non-Small Cell Lung Cancer (NSCLC) management remains a formidable challenge in the field of oncology, representing significant global health burden [...].
Language: Английский
Citations
4
Cancer Letters, Journal Year: 2024, Volume and Issue: 588, P. 216802 - 216802
Published: March 11, 2024
Language: Английский
Citations
4
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 158 - 158
Published: Jan. 24, 2025
Recently, the curcumin derivative CU17 possessing HDAC inhibitory activity has been shown to synergistically enhance anti-proliferative of Gem against lung cancer cells. Nevertheless, mechanism(s) underlying synergistic anti-cancer effect remains be investigated. This study aimed investigate mechanisms that underpin combined and NSCLC A549 cells both in vitro mouse xenograft models. was successfully synthesized subsequently investigated for its combination effects with on inductions cell cycle arrest apoptosis The treatment substantially decreased survival through S phase prolongation G2/M via up-regulating expressions p21 p53 proteins. Additionally, potentiated apoptotic by increasing Bax/Bcl-2 ratio. co-treatment resulted an up-regulation pERK1/2 Ac-H3 expression. An vivo demonstrated significantly improved nude mice utilizing xenografts. hematoxylin eosin (H&E) staining results indicated toxicity liver, kidneys, spleen. Overall, enhanced effectiveness while decreasing toxicity. compound shows promise as a chemosensitizer Gem.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 28, 2025
Language: Английский
Citations
0
BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 28, 2025
Airway inflammation is believed to play a crucial role in the development and progression of non-small cell lung cancer (NSCLC). However, no study has yet employed quantified imaging biomarkers assess airway patients with NSCLC. This aimed validate hypothesis that more pronounced large cohort NSCLC compared controls, using derived from fluorine-18-fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET), as well explore their associations clinical parameters. We retrospectively enrolled 618 441 controls who underwent F-18 FDG PET/computed (CT). The PET/CT images were subjected segmentation determine maximum standardized uptake value (SUVmax) total lesion glycolysis (TLG). PET parameters between controls. Additionally, we investigated tumor SUVmax, stages, smoking pack-years, histological subtypes, systemic inflammation, function median SUVmax (P < 0.0001) TLG significantly higher than = 0.0098) squamous carcinoma those adenocarcinoma. showed weak positive correlations white blood count, neutrophil-to-lymphocyte ratio, but moderate negative correlation pack-years. PET-derived these associated serologic inflammatory markers, function, smoking, suggesting potential provide insights into severity
Language: Английский
Citations
0
Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11
Published: May 25, 2023
In recent years, the unique and diverse physicochemical properties of nanoparticles have brought about their wide use in many fields; however, it is necessary to better understand possible human health risks caused by release environment. Although adverse effects been proposed are still being clarified, on lung not fully studied. this review, we focus latest research progress pulmonary toxic nanoparticles, summarized disturbance inflammatory response. First, activation inflammation was reviewed. Second, discussed how further exposure aggravated ongoing inflammation. Third, inhibition loaded with anti-inflammatory drugs. Forth, introduced affect related disturbance. Finally, main gaps current challenges countermeasures future research.
Language: Английский
Citations
9
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(24), P. 17325 - 17325
Published: Dec. 10, 2023
Lung cancer is the leading cause of cancer-related death worldwide. Its high mortality partly due to chronic inflammation that accompanies disease and stimulates progression. In this review, we analyzed recent studies highlighted role epithelial-mesenchymal transition (EMT) as a link between lung cancer. inflammatory tumor microenvironment (iTME), fibroblasts, macrophages, granulocytes, lymphocytes produce mediators, some which can induce EMT. This leads increased invasiveness cells self-renewal stem (CSCs), are associated with metastasis recurrence, respectively. Based on published data, propose inflammation-induced EMT may be potential therapeutic target for treatment prospect partially realized in development inhibitors based pentacyclic triterpenoids (PTs), described second part our study. PTs reduce metastatic stemness cells, making promising candidates therapy. We emphasize diversity molecular mechanisms underlying far exceeds those have been implicated drug development. Therefore, analysis information relationship iTME great interest provide ideas novel approaches
Language: Английский
Citations
9
Cancer Reports, Journal Year: 2024, Volume and Issue: 7(4)
Published: April 1, 2024
Abstract Background NSCLC is a lethal cancer that highly prevalent and accounts for 85% of cases lung cancer. Conventional treatments, such as chemotherapy radiation, frequently exhibit limited efficacy notable adverse reactions. Therefore, drug repurposing method proposed effective treatment. Aims This study aims to evaluate candidate drugs are at the clinical level using systems biology network analysis approach. Methods Differentially expressed genes in transcriptomics data were identified approaches. A gene co‐expression was developed with aim detecting two modules co‐expression. Following that, Drug–Gene Interaction Database used find possible target important within linked non‐small cell (NSCLC). The use Cytoscape facilitated creation drug–gene interaction network. Finally, set enrichment done validate drugs. Results Unlike previous research on repositioning NSCLC, which uses network, this project first both co‐occurrence networks. And also differentially cells their adjacent normal cells. For management (NSCLC), show higher regulation affinity thought be important. According discourse, have lot control over medicines like vincristine, fluorouracil, methotrexate, clotrimazole, etoposide, tamoxifen, sorafenib, doxorubicin, pazopanib. Conclusion Hence, there possibility these treatment non‐small‐cell
Language: Английский
Citations
3
Cancer Reports, Journal Year: 2023, Volume and Issue: 7(2)
Published: Dec. 18, 2023
Abstract Background Recently, immunotherapy has become very hopeful for cancer therapy. Cancer treatment through excellent specificity and less toxicity than conventional chemoradiotherapy. Pathogens have been used in a long time. The current study aims to evaluate the possibility of Toxoplasma gondii ( T. ) as probable cancers such melanoma, breast, ovarian, lung, pancreatic cancer. Recent findings Nonreplicating type I uracil auxotrophic mutants can stimulate immune responses against tumors by reverse immunosuppression at cellular level. be utilized research T helper 1 (Th1) cell immunity intracellular infections. Avirulent auxotroph vaccine change tumor's improve production cytokines, i.e., Interferon‐gamma (IFN‐γ) Interleukin‐12 (IL‐12) activate tumor‐related Cluster Differentiation 8 (CD8+) cells identify destroy cells. profilin protein, along with secreted proteins, found exhibit promising properties various cancers. These proteins are being studied their potential inhibit tumor growth enhance effectiveness therapies. Their unique mechanisms action make them valuable candidates targeted interventions ovarian cancer, breast lung treatments. Conclusion In summary, underscores significant harnessing , including its diverse array antigens, particularly avirulent form, groundbreaking approach immunotherapy.
Language: Английский
Citations
7
ACS Applied Nano Materials, Journal Year: 2023, Volume and Issue: 6(22), P. 21371 - 21384
Published: Nov. 14, 2023
Lung adenocarcinoma is regarded as the most common form of lung cancer, per latest epidemiological data. The combined efforts from chemotherapy and radiotherapy have done little to increase survival rates. Thus, repurposing licensed drugs has become a feasible approach filling such gaps. Levocetirizine dihydrochloride, antihistamine, been loaded into copper nanoclusters. subsequent levocetirizine nanoclusters were mannose functionalized chitosan nanoparticles. This therapeutic module established target cells in both monolayer tumor spheroids. nanocomposite was found be inherently fluorescent, biocompatible, water-soluble. drug release profile pH-dependent, with maximum acidic medium. Experimental results concluded efficient cellular localization followed by significant antiproliferative activity. Subsequent functional assays revealed suggestive reactive oxygen species generation, membrane potential depolarization, reduced lipid droplets leading up apoptosis. A remarkable reduction colony formation migration capacity also observed. They inhibited spheroids A549 HeLa cells. Briefly, as-synthesized nanocomposites showed promising scope an anticancer treatment approach.
Language: Английский
Citations
6