RNA Combined with Nanoformulation to Advance Therapeutic Technologies

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(12), P. 1634 - 1634

Published: Nov. 21, 2023

Nucleic acid-based therapies have the potential to address numerous diseases that pose significant challenges more traditional methods. RNA-based emerged as a promising avenue, utilizing nanoformulation treatments target range of pathologies. Nanoformulation offers several advantages compared other treatment modalities, including targeted delivery, low toxicity, and bioactivity suitable for drug loading. At present, various types nanoformulations are available, such liposomes, polymeric nanoparticles (NPs), magnetic NPs, nanoshells, solid lipid (SLNs). therapy utilizes intracellular gene with messenger RNA (mRNA) emerging prominently in cancer immunotechnology against infectious diseases. The approval mRNA-based technology opens doors future technological advancements, particularly self-amplifying replicon (repRNA). RepRNA is novel platform therapy, comprising viral unique molecular property enables amplification all encoded genetic information countless times. As result, repRNA-based achieved levels expression. In this context, primary objective study furnish comprehensive review repRNA its applications treatments, specific focus on encapsulated nanoparticles. overarching goal provide an extensive overview use conjunction across therapies.

Language: Английский

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Application of natural compounds in the treatment and prevention of prediabetes

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Nov. 30, 2023

Prediabetes is an intermediate stage in the development of type 2 diabetes mellitus characterized by impaired fasting glucose and/or tolerance. generally has no obvious clinical symptoms, and most patients are found health examinations or due to other diseases. Reactive hypoglycemia may indicate possibility early diabetes. Without effective preventive measures, prediabetes can progress leading serious public problems. Therefore, diagnosis intervention important. Many animal experiments trials have proven that natural compounds substantially improve metabolism disorder. The active ingredients mainly alkaloids, polysaccharides, saponins, terpenoids, flavonoids polyphenols. Their mechanism action involves improved insulin sensitivity resistance, inhibited activity alpha-glucosidase, antioxidant activity, anti-inflammatory, regulation gut microbiota activating peroxisome proliferator-activated receptor-γ. This paper reviews mechanisms on status related research.

Language: Английский

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Anthocyanin-Based Natural Dyes and Nanoscale Coatings

Engineering materials, Journal Year: 2024, Volume and Issue: unknown, P. 209 - 239

Published: Jan. 1, 2024

Language: Английский

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Flavonoids and Nanotechnology in Insulin Resistance Diabetic Complications

Published: Aug. 27, 2024

Diabetes is a persistent metabolic disorder characterized by elevated blood sugar levels, potentially leading to complications such as diabetic retinopathy, neuropathy, and nephropathy if not effectively managed. Although synthetic medications are available for diabetes treatment, their prolonged use often results in significant adverse effects. Flavonoids, occurring naturally various groups, present an alternative therapeutic avenue. Recent research over the past few decades has emphasized potential of flavonoids management diabetes. However, notable limitation lies fact that most these compounds lack solubility water, thereby limiting effectiveness when administered standard doses. To overcome this hurdle, scientists have developed nanostructures tailored flavonoids, with aim enhancing solubility, absorption, overall impact. The utilization nanocarriers shows immense promise improving accessibility dietary flavonoids. These carriers encompass diverse spectrum nanoparticles, including polymers, solid lipid nanoparticles (SLNs), nanostructured (NLCs), micelles, liposomes, nanosuspensions, nanoemulsions. Comprehensive studies conducted across ex vivo , vitro systems suggest combinations offer heightened potential, particularly addressing conditions cancer

Language: Английский

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Exploring the Therapeutic Power of Flavonoids on Chronic Disease

Published: Aug. 27, 2024

This book chapter addresses the potential of flavonoids as a promising therapeutic intervention in amelioration chronic diseases, specifically through their regulatory influence on MAPK and NF-κB signaling cascades. Chronic diseases pose an overwhelming global burden, urging need for effective strategies. Flavonoids, polyphenolic compounds ubiquitous plant-based diets, have historically displayed vast medicinal attributes, including anti-inflammatory, antioxidant, anticancer activities. However, precise mechanisms underlying these effects remain relatively elusive. focuses biochemical interaction with complex MAPKs/NF-KB pathways, known fundamental role cell survival, inflammation, immunity. The existing preclinical clinical evidence elucidates compelling agents management diseases. By intervening may suppress inflammatory responses, enhance cellular antioxidant defenses, induce apoptosis cancer cells, providing innovative approach to disease management. Potential applications, comparative analysis treatments, side effects, future research directions are extensively discussed, underscoring promise challenges utilizing power flavonoids. comprehensive provides platform further into molecular flavonoids, ultimately contributing our fight against

Language: Английский

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