Evaluation of the Interaction between Carvacrol and Thymol, Major Compounds of Ptychotis verticillata Essential Oil: Antioxidant, Anti-Inflammatory and Anticancer Activities against Breast Cancer Lines

Life, Journal Year: 2024, Volume and Issue: 14(8), P. 1037 - 1037

Published: Aug. 20, 2024

The objective of this study was to evaluate the antioxidant, anti-inflammatory, and anticancer properties thymol, carvacrol, their equimolar mixture. Antioxidant activities were assessed using DPPH, ABTS, ORAC methods. thymol/carvacrol mixture exhibited significant synergism, surpassing individual compounds ascorbic acid in DPPH (IC

Language: Английский

---

Aridity Gradients Shape Intraspecific Variability of Morphological Traits in Native Ceratonia siliqua L. of Morocco

Plants, Journal Year: 2023, Volume and Issue: 12(19), P. 3447 - 3447

Published: Sept. 30, 2023

The carob tree (Ceratonia siliqua L.) is a significant fruit in the Mediterranean region with cultural, biological, and ecological importance. Despite its importance, intraspecific trait variability (ITV) trees has been largely overlooked previous studies. Understanding ITV relationship environmental conditions crucial for conservation breeding programs. In this study, we investigated of pod seed-related traits across different scales 25 studied populations Morocco. Significant differences morphological were observed between at various levels, pod-related exhibited greater than seed traits. Correlation analysis revealed strong associations conditions, altitude aridity index playing an influential role. gradient was strongly related to changes size, number, as well yield. Our findings highlight important reaching 45% intra-population level, 36.5% inter-geographic 30% inter-population level. Overall, study contributes valuable insights into ecology adaptation trees, emphasizing importance considering when studying remarkable species. This knowledge critical addressing challenges posed by climate change human activities on long-term survival functioning populations.

Language: Английский

---

Chemical Profiling, Antibacterial Efficacy, and Synergistic Actions of Ptychotis verticillata Duby Essential Oil in Combination with Conventional Antibiotics

Natural Product Communications, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 1, 2024

Introduction: The primary aim of the current investigation is to assess chemical composition and antibacterial efficacy Ptychotis verticillata essential oil (PVEO) against three Gram-positive bacteria ( Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis) Gram-negative Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae). Furthermore, this research endeavors investigate potential synergistic effects PVEO when combined with established antibiotics (Amoxicillin, Erythromycin, Ampicillin), a focus on discerning their interaction dynamics. Methods: phytochemical profiling was performed via Gas Chromatography-Mass Spectrometry technique. broth dilution test determined effect between these antibiotics. Results: Components γ-terpinene (38.96%), p-cymene (19.38%), thymol (18.07%), carvacrol (6.99%) are major bioactive moleculs composing studied oil. demonstrated significant activity minimum inhibitory concentration (MIC) values ranging from 0.2 E coli 2 mg/mL M luteus. assessment accomplished through utilization Fractional Inhibitory Concentration Index (FICI). combination amoxicillin luteus best action FICI value 0.43. Conclusion: Significant reductions, two sevenfold, in MIC PVEO, were observed. This noteworthy highly potent oils synthetic holds open avenues for novel therapies aimed at addressing infections caused by multiresistant microorganisms, even notably reduced concentrations within pharmaceutical sector.

Language: Английский

---

Evaluation of carob tree (Ceratonia siliqua L.) pods, through three different drying techniques, and ultrasonic assisted extraction, for presence of bioactives

South African Journal of Botany, Journal Year: 2024, Volume and Issue: 173, P. 388 - 396

Published: Aug. 29, 2024

Language: Английский

---

Bio-based chemical analysis of extracts from the biomass residues of Ceratonia siliqua and Ziziphus spina-christi with their bioactivities against molecularly identified fungi

Biomass Conversion and Biorefinery, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Language: Английский

---

Elicitor-driven enhancement of phenolic compounds in geranium callus cultures: phytochemical profiling via LC-MS/MS and biological activities

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: March 7, 2025

This research explores the effects of chitosan (CHT) and salicylic acid (SA) as elicitors on production phenolic flavonoid compounds in Pelargonium graveolens Hort. Callus cultures solid media, aiming to enhance antioxidant, anti-tyrosinase, anti-elastase properties. Calli were treated with various concentrations CHT (25, 50, 75, 100 mg/mL) SA µM), their phytochemical profiles examined through LC-MS/MS analysis. The findings indicated that notably enhanced levels total content (TPC) (TFC). greatest increase TPC was seen 25 µM (SA 2 ), recording 336.80 ± 8.35 mg/100 g dry weight (DW), mg/mL (CHT 5 which showed 325.74 7.81 DW. Among individual phenolics, kaempferol a remarkable under (192.82 17.99 DW) compared control (103.68 5.00 DW), treatment (119.68 12.01 DW). Additionally, rutin accumulation peaked at 30.64 3.00 DW treatment. Antioxidant activities, measured by DPPH TAC assays, also enhanced, treatments showing significant improvement over control. -elicited exhibited superior anti-tyrosinase IC 50 values 51.43 1.31 μg/mL, 35.42 4.42 31.84 0.60 respectively. These suggest effectively boost bioactive compound P. calli, subsequently biological activity, highlighting potential developing natural skincare products antioxidant anti-aging benefits.

Language: Английский

---

Study of the effect of dryness and storage on Ceratonia siliqua L. stem extracts and evaluation of their insecticidal activity

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 1, 2025

Abstract Vector-borne diseases continue to transmit many dangerous pathogens humans. After decades of continuous use insecticides, types vectors have shown the ability build resistance them. This has necessitated development more efficient and environmentally friendly alternatives in form bioinsecticides. Plants contain a wide range phytochemicals with specific targeting, rapid biodegradability, environmental sustainability variety medicinal properties, making them valuable source biologicals. Moreover, this led highly effective new drugs. study aimed identify active ingredients Ceratonia siliqua L., gathered from two consecutive fruiting seasons which were then divided into C. fresh (CSF), dry (CSd), old (stored) stem (CSO) extracts . Metabolomics profiling was performed using UPLC/MS multivariate data analysis. The resulted tentative identification 54 secondary metabolites. These compounds included flavonoids, phenolic acids, withanolides, terpenoids, phenylpropanoids, etc. CSd showed highest number identified components followed by CSO CSF. % nearly equal negative ion mode for three while positive it order CSF > CSO. several exposure periods, plant methanol research significant insecticidal activity against mosquito larvae, Cx. pipiens , housefly larvae M. domestica (CSd) demonstrated (100 MO%) (LC 50 = 0.09 0.07 mg/ml) following 24- 48-hour post-treatments at 1.0 mg/ml. (CSF) most on 2.32 1.80 mg/ml), 24 48 h post-treatment 25 mg/ml concentration. Both killing house fly extract. Therefore, may serve as an bio-agent vector-borne infection control.

Language: Английский

---

Chemical Analysis, Antihyperglycemic Properties and Enzyme Inhibition of Opuntia dillenii (Ker Gawl.) Haw: A Detailed Analysis of Pulp and Peel Extracts

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101320 - 101320

Published: April 1, 2025

Language: Английский

---

Carob (Ceratonia siliqua L.) Seed Constituents: A Comprehensive Review of Composition, Chemical Profile, and Diverse Applications

Journal of Food Quality, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 14

Published: Nov. 21, 2023

Carob (Ceratonia siliqua L.) is a tree species native to the Mediterranean region and belongs Fabaceae family. The well-known for its sweet nutritious fruits, which have been used long time as food. In addition edible carob also produces seeds that are highly prized their ability produce gum (locust bean gum). seed consists of three main components: shell, endosperm, embryo. shell outermost layer seed, followed by largest part contains high levels carbohydrates proteins. embryo smallest rich on bioactive compounds. constituents attracted considerable attention due exceptional nutritional therapeutic properties in various industries, including food, medicine, pharmaceuticals, cosmetics, textiles. content compounds seeds, such polyphenols, tannins, flavonoids, believed be responsible antioxidant anti-inflammatory properties. use food industry mainly act thickeners stabilizers foods. They substitute other thickening agents guar carrageenan, superior pharmaceutical industry, found antidiabetic, antihyperlipidemic, anticancer properties, among others. cosmetics interested ingredients they can improve hydration elasticity skin. natural alternative synthetic cosmetic formulations. textile has recognized potential constituents, dye sizing agent strength durability summary, offer wide range applications owing compounds, excellent profile, thickeners, stabilizers, antioxidants. This review highlighted latest findings chemical composition, applications, health benefits constituents.

Language: Английский

---

Carob (Ceratonia siliqua L.), Pharmacological and Phytochemical Activities of Neglected Legume of the Mediterranean Basin, as Functional Food

Reviews on Recent Clinical Trials, Journal Year: 2024, Volume and Issue: 19(2), P. 127 - 142

Published: Jan. 29, 2024

Carob (

Language: Английский

---