Molecules,
Journal Year:
2025,
Volume and Issue:
30(5), P. 1186 - 1186
Published: March 6, 2025
The
Chamaenerion
genus,
particularly
angustifolium
and
latifolium,
is
recognized
for
its
rich
phytochemical
composition
extensive
medicinal
properties.
These
species
are
abundant
in
polyphenols,
flavonoids,
tannins,
which
contribute
to
their
potent
antioxidant,
antimicrobial,
anticancer
activities.
This
review
provides
a
comprehensive
analysis
of
constituents,
with
an
emphasis
on
how
processing
methods,
including
fermentation,
influence
bioactivity.
Notably,
fermentation
enhances
the
levels
key
bioactive
compounds,
such
as
oenothein
B,
gallic
acid,
ellagic
thereby
increasing
pharmacological
potential.
Additionally,
this
evaluates
biological
activities
relation
chemical
composition,
while
also
considering
limitations
current
studies,
lack
vivo
or
clinical
trials.
literature
was
sourced
from
scientific
databases,
PubMed,
Scopus,
ScienceDirect,
covering
research
2010
2024.
Future
studies
should
focus
optimizing
extraction
elucidating
synergistic
bioactivities,
conducting
in-depth
trials
validate
efficacy
safety.
MGM Journal of Medical Sciences,
Journal Year:
2025,
Volume and Issue:
12(1), P. 155 - 165
Published: Jan. 1, 2025
Abstract
Artificial
intelligence
(AI)
has
significantly
impacted
drug
discovery
and
development,
playing
a
pivotal
role
in
the
creation
of
potent
affordable
antimicrobial
drugs.
The
COVID-19
pandemic
underscored
urgent
need
for
new,
effective
formulations
to
combat
continuously
evolving
microbial
threats.
Plant-based
formulations,
known
their
long
history
effectiveness
against
various
infections,
including
antimicrobial-resistant
strains,
have
proven
value
centuries.
Unlike
conventional
synthetic
drugs,
phytoconstituent-based
generally
fewer
side
effects
reduced
cytotoxicity
when
used
appropriate
doses.
application
AI
development
drugs
derived
from
bioactive
phytocompounds
derivatives
is
vital
addressing
challenges
posed
by
rapidly
pathogens.
tools
provide
more
efficient
comprehensive
approach
exploring
vast
array
medicinal
plant
compounds,
allowing
identification
those
with
highest
potential.
This
review
focuses
on
developing
bacterial,
viral,
fungal,
other
It
also
discusses
how
can
revolutionize
expedite
process
accelerating
potential
phytocompounds,
offering
faster
alternative
traditional
methods.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(3), P. e0299378 - e0299378
Published: March 11, 2024
Antibiotics
are
the
drugs
that
used
for
management
of
microbial
diseases.
However,
these
conventional
synthetic
can
harmfully
affect
human
health.
Since
phytochemicals
extracted
from
natural
sources
and,
hence
relatively
safer
health,
they
enticing
alternatives
in
this
regard.
Cinnamon
is
also
one
those
plants
which
being
employed
as
herbal
medication
centuries
against
certain
infections
due
its
significant
therapeutic
effectiveness.
A
well-known
pathogenic
bacterium
called
H
.
pylori
causes
a
wide
range
illnesses
body.
This
pathogen’s
pathogenicity
determined
by
virulent
proteins.
In
study,
some
such
proteins,
included
virB4
,
virB8
and
virB9
were
selected
to
evaluate
efficiency
cinnamon
compounds.
These
proteins
identified
different
isolates
The
structural
modelling
all
performed
initially
order
proceed
them
molecular
docking
analysis.
While,
studies
illustrated
compounds,
cinnamyl
acetate
showed
binding
interactions
with
benzyl
benzoate
another
compound,
docked
well
Afterwards,
MD
simulations
incorporated
explore
interaction
motions
stability
complexes.
regard,
resultant
maps
Bfactor,
eigenvalues
elastic
network
model,
among
other
factors
ensured
stabilities
respective
After
crucial
estimations,
underwent
ADMET
investigation
assess
their
pharmacokinetic
characteristics.
SwissADME
ADMETLab
2.0
server
investigation.
compiled
findings
servers
revealed
both,
exhibited
level
drug-likeness
conformity.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(9), P. 6096 - 6111
Published: Jan. 1, 2024
Christella
dentata
(Forssk.)
Brownsey
&
Jermy
has
been
commonly
used
in
traditional
medicinal
practices
but
its
effects
on
multi-drug-resistant
(MDR)
bacteria
have
remained
unexplored.
Microorganisms,
Journal Year:
2023,
Volume and Issue:
11(9), P. 2264 - 2264
Published: Sept. 9, 2023
Antimicrobial
resistance
(AMR)
has
emerged
as
a
global
health
crisis,
necessitating
the
search
for
innovative
strategies
to
combat
infectious
diseases.
The
unique
biodiversity
of
Italian
flora
offers
treasure
trove
plant
species
and
their
associated
phytochemicals,
which
hold
immense
potential
solution
address
AMR.
By
investigating
antimicrobial
properties
phytochemical
constituents,
this
study
aims
shed
light
on
phyto-complexes
valuable
resource
developing
novel
or
supportive
agents
useful
animal
production.
